Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kay Klapproth"'
Autor:
Joschka Heil, Victor Olsavszky, Katrin Busch, Kay Klapproth, Carolina de la Torre, Carsten Sticht, Kajetan Sandorski, Johannes Hoffmann, Hiltrud Schönhaber, Johanna Zierow, Manuel Winkler, Christian David Schmid, Theresa Staniczek, Deborah E. Daniels, Jan Frayne, Georgia Metzgeroth, Daniel Nowak, Sven Schneider, Michael Neumaier, Vanessa Weyer, Christoph Groden, Hermann-Josef Gröne, Karsten Richter, Carolin Mogler, Makoto Mark Taketo, Kai Schledzewski, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Koch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre dri
Externí odkaz:
https://doaj.org/article/807900d34c274dcfa83939c240d17adf
Autor:
Tobias Weinberger, Dena Esfandyari, Denise Messerer, Gulce Percin, Christian Schleifer, Raffael Thaler, Lulu Liu, Christopher Stremmel, Vanessa Schneider, Ronald J. Vagnozzi, Jennifer Schwanenkamp, Maximilian Fischer, Katrin Busch, Kay Klapproth, Hellen Ishikawa-Ankerhold, Lukas Klösges, Anna Titova, Jeffery D. Molkentin, Yasuhiro Kobayashi, Stefan Engelhardt, Steffen Massberg, Claudia Waskow, Elisa Gomez Perdiguero, Christian Schulz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating m
Externí odkaz:
https://doaj.org/article/9736be91c4674079bfa53c6a81afee95
Autor:
Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka, Elke Burgermeister
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Only a small subset of colorectal cancer (CRC) patients benefits from immunotherapies, comprising blocking antibodies (Abs) against checkpoint receptor “programmed-cell-death-1” (PD1) and its ligand (PD-L1), because most cases lack the required m
Externí odkaz:
https://doaj.org/article/76d82438b7e2457c9fd5fa68a566c022
Autor:
Maximilian Eckardt, Kay Klapproth, Veronika Hauber, Philip Weidner, Michael Boutros, Tianzuo Zhan, Matthias P. Ebert, Beifang Li, Timo Gaiser, Wenyue Wu, Jens Pahl, Sebastian Belle, Frank Herweck, Elke Burgermeister, Adelheid Cerwenka, Torsten Schroeder, Juliane Reichling, Laura Helm, Ioana Dobrota, Carsten Sticht, Tobias Gutting, Johannes Betge
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
Oncoimmunology
article-version (VoR) Version of Record
Only a small subset of colorectal cancer (CRC) patients benefits from immunotherapies, comprising blocking antibodies (Abs) against checkpoint receptor “programmed-cell-death-1” (PD1) and its ligand (PD-L1), because most cases lack the required m
Autor:
Michael Neumaier, Carolin Mogler, Carolina De La Torre, Katrin Busch, Jan Frayne, Carsten Sticht, Kajetan Sandorski, Johannes Hoffmann, Vanessa Weyer, Makoto Mark Taketo, Daniel Nowak, Victor Olsavszky, Philipp-Sebastian Koch, Christian Schmid, Kay Klapproth, Deborah E. Daniels, Karsten Richter, Sven Schneider, Sergij Goerdt, Joschka Heil, Johanna Zierow, Kai Schledzewski, Hiltrud Schönhaber, Hermann-Josef Gröne, Christoph Groden, Georgia Metzgeroth, Cyrill Géraud, Theresa Staniczek, Manuel Winkler
Publikováno v:
Nature Communications
Heil, J, Olsavszky, V, Daniels, D, Frayne, J & Koch, P-S 2021, ' Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation ', Nature Communications, vol. 12, no. 1, 6963 . https://doi.org/10.1038/s41467-021-27161-3
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Heil, J, Olsavszky, V, Daniels, D, Frayne, J & Koch, P-S 2021, ' Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation ', Nature Communications, vol. 12, no. 1, 6963 . https://doi.org/10.1038/s41467-021-27161-3
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Within the bone marrow microenvironment, endothelial cells (EC) exert important functions. Arterial EC support hematopoiesis while H-type capillaries induce bone formation. Here, we show that BM sinusoidal EC (BM-SEC) actively control erythropoiesis.
Autor:
Kai Schledzewski, Thomas Henzler, Kay Klapproth, Bernd Arnold, Victor Olsavszky, Carsten Sticht, Mathias Meyer, Sergij Goerdt, Sven Schneider, Katja Breitkopf-Heinlein, Alexandra Demory, Philipp-Sebastian Koch, Johanna Zierow, H Gaitantzi, Friederike Ulbrich, Cyrill Géraud, Bradley Spencer-Dene, Thomas Leibing
Microvascular endothelial cells (ECs) display a high degree of phenotypic and functional heterogeneity among different organs. Organ-specific ECs control their tissue microenvironment by angiocrine factors in health and disease. Liver sinusoidal endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb0e0ef2d565c3543c711f471990b44
https://europepmc.org/articles/PMC5291964/
https://europepmc.org/articles/PMC5291964/
Autor:
Kathrin Frenzel, Alexander R. Pinto, Bernard Malissen, Kay Klapproth, Nadia Rosenthal, Prashanth K. Kandalla, Kaaweh Molawi, Sandrine Henri, Marc Bajénoff, Hans Reimer Rodewald, Michael H. Sieweke, Steffen Jung, Marco Prinz, Yochai Wolf, Jeremy Favret, Nora Hagemeyer
Publikováno v:
The Journal of Experimental Medicine
Molawi et al. examine the origin and cellular dynamics of macrophages in the heart during postnatal development. Cardiac macrophages derived from CX3CR1+ embryonic progenitors persist into adulthood, but the contribution of these cells to resident ma
Publikováno v:
The Journal of Pathology. 229:775-783
Burkitt lymphoma (BL) is caused by translocation of the MYC gene to an immunoglobulin locus resulting in its constitutive expression depending on the activity of the immunoglobulin (Ig) enhancer elements. Treatment of BL cell lines with epigenetic mo
Autor:
Sandhya Singh, Karsten Richter, Sergij Goerdt, Sanna Maria Karppinen, Johanna Zierow, Hellmut G. Augustin, Katrin Busch, Kai Schledzewski, Thomas Leibing, Victor Olsavszky, Philipp Koch, Kay Klapproth, Hans Reimer Rodewald, Bernd Arnold, Cyrill Géraud, Miriam Diett, Carsten Sticht, Taina Pihlajaniemi, Alexandra Demory, Katja Breitkopf-Heinlein, Friederike Ulbrich
Publikováno v:
The Journal of clinical investigation. 127(3)
Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific gatekeepers of their microenvironment. Microvascular ECs instruct neighboring cells in their organ-specific vascular niches through angiocrine factors, which include
Publikováno v:
Annual review of immunology. 34
Hematopoietic stem cells (HSCs) and downstream progenitors have long been studied based on phenotype, cell purification, proliferation, and transplantation into myeloablated recipients. These experiments, complemented by data on expression profiles,