Insights for Educational Practice from a Thematic Analysis of Student Experiences with Speculative Design Mini-Projects about Personal Issues

Autor: Kay Kender, Peter Purgathofer

Publikováno v: Interaction Design and Architecture(s), Iss 51, Pp 249-269 (2021)

In 2020, we gave a large-scale first-year informatics course an assignment to speculatively design hypothetical solutions for issues they were experiencing due to social distancing measures during the COVID-19 pandemic. In this paper, we present a sp

Externí odkaz: https://doaj.org/article/231b11045e8b4c55804e083a779fe031

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition.

Autor: Kay KE; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Lee J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Hong ES; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Beilis J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Dayal S; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Wesley ER; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Mitchell S; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Wang SZ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Silver DJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Volovetz J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Johnson S; Rose Ella Burkhardt Brain Tumor Center, Cleveland Clinic, Cleveland, United States of America., McGraw M; Rose Ella Burkhardt Brain Tumor Center, Cleveland Clinic, Cleveland, United States of America., Grabowski M; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Lu T; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Freytag L; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Narayana VK; Metabolomics Australia, The University of Melbourne, Melbourne, Australia., Freytag S; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Best SA; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Whittle JR; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Wang Z; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Reizes O; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Yu JS; Department of Cancer Biology, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Hazen SL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Brown JM; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Bayik D; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America., Lathia J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States of America.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma.

Autor: Hong ES; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.; Medical Scientist Training Program (MSTP), School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Wang SZ; Medical Scientist Training Program (MSTP), School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Ponti AK; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA., Hajdari N; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lee J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Mulkearns-Hubert EE; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA., Volovetz J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA., Kay KE; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA., Lathia JD; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Cleveland, Ohio, USA., Dhawan A; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Cleveland, Ohio, USA.; School of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 12. Date of Electronic Publication: 2024 Mar 12.

Homeostatic iron regulatory protein drives glioblastoma growth via tumor cell-intrinsic and sex-specific responses.

Autor: Troike KM; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Wang SZ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA., Silver DJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Lee J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Mulkearns-Hubert EE; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Hajdari N; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Ghosh PK; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Kay KE; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Beilis JL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Mitchell SE; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Bishop CW; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Hong ES; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Artomov M; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Pediatrics, The Ohio State Wexner Medical Center, Columbus, Ohio, USA., Hubert CG; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA., Rajappa P; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Neurological Surgery, The Ohio State Wexner Medical Center, Columbus, Ohio, USA., Connor JR; Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA., Fox PL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Kristensen BW; Department of Clinical Medicine, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark., Lathia JD; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2023 Nov 28; Vol. 6 (1), pp. vdad154. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2024).

Metaorganismal choline metabolism shapes olfactory perception.

Autor: Massey WJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA., Kay KE; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA., Jaramillo TC; Rodent Behavior Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Horak AJ 3rd; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Cao S; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Osborn LJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA., Banerjee R; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Mrdjen M; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Hamoudi MK; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Silver DJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Burrows AC; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Brown AL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Reizes O; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Lathia JD; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Wang Z; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA., Hazen SL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA., Brown JM; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA. Electronic address: brownm5@ccf.org.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Nov; Vol. 299 (11), pp. 105299. Date of Electronic Publication: 2023 Sep 28.