Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kay Eckersley"'
Autor:
Dominic I. James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A. Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D. Waddell, Donald J. Ogilvie
Publikováno v:
F1000Research, Vol 5 (2016)
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molec
Externí odkaz:
https://doaj.org/article/ba6ce5180d66401bab9aed77f463d36a
Autor:
Dominic I. James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A. Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D. Waddell, Donald J. Ogilvie
Publikováno v:
F1000Research, Vol 5 (2016)
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molec
Externí odkaz:
https://doaj.org/article/e7dd00005ec345b7ab552741d559242f
Autor:
Nicolas E. S. Guisot, Richard Armer, Inder Bhamra, Kay Eckersley, Peter Bunyard, Claire Chaplin, Caroline Phillips, Cliff Jones
Publikováno v:
Mechanisms of lung injury and repair.
Wnt signalling is strongly associated with Idiopathic Pulmonary Fibrosis (IPF) with gene expression and proteomics analysis suggesting that approximately half of all patients may exhibit enhanced pathway activation during the progression of the disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dc58c768cdf2ce667fd239c2bee042f
https://doi.org/10.1183/13993003.congress-2019.pa589
https://doi.org/10.1183/13993003.congress-2019.pa589
Autor:
Jon Read, Kevin Michael Foote, Johannes Wilhelmus Maria Nissink, Alan Lau, Louise Goodwin, Lisa Wissler, Jason Breed, Benjamin Taylor, Nichola L. Davies, Husam Alwan, James S. Scott, Jason Grant Kettle, Kay Eckersley, D.R Jones, Michal Bista, Marta Wylot, Graeme Walker, Shaun M. Fillery, Helena Käck
Publikováno v:
Journal of Medicinal Chemistry. 59:2346-2361
Recent literature has claimed that inhibition of the enzyme MTH1 can eradicate cancer. MTH1 is one of the "housekeeping" enzymes that are responsible for hydrolyzing damaged nucleotides in cells and thus prevent them from being incorporated into DNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da178d427c92c2b105e4b0b1f3a2bf
https://doi.org/10.1021/acs.jmedchem.5b01760
https://doi.org/10.1021/acs.jmedchem.5b01760
Autor:
Kevin Hudson, Richard Mott, Richard A. Ward, Jonathan D. Wrigley, Stephen W. Peters, Ian M. Hardern, Lindsey Millard, Thorsten Nowak, Peter B. Simpson, Kay Eckersley, Michael Walters
Publikováno v:
Cell Biochemistry and Biophysics. 60:99-111
USP7 (HAUSP) is a deubiquitinating enzyme, which plays a crucial role in regulating the levels of the p53 tumour suppressor protein, through its ability to prevent the proteasomal degradation of the Ubiquitin ligase for p53, Hdm2. Supporting evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0167479c489d7167ca78100a9638f5
https://doi.org/10.1007/s12013-011-9186-4
https://doi.org/10.1007/s12013-011-9186-4
Autor:
Philip Hopcroft, Lyman Feron, Tina Howard, Kay Yeung, Mairi Challinor, Judit E. Debreczeni, Michael Tonge, Vikki Flemington, Lindsay Snow, Clifford David Jones, Ryan Greenwood, Michael James, Nicola Colclough, Mark A. Graham, Kay Eckersley, Gary Fairley, Christopher R. Jones, Karen Roberts, Richard A. Ward, Jonathan Renshaw
Publikováno v:
Journal of medicinal chemistry. 58(11)
The RAS/RAF/MEK/ERK signaling pathway has been targeted with a number of small molecule inhibitors in oncology clinical development across multiple disease indications. Importantly, cell lines with acquired resistance to B-RAF and MEK inhibitors have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32444a8e998a729846aff970c090bac
https://pubmed.ncbi.nlm.nih.gov/25977981
https://pubmed.ncbi.nlm.nih.gov/25977981
Autor:
Kevin Michael Foote, David Jones, James S. Scott, Graeme Walker, Jason Grant Kettle, Benjamin J. M. Taylor, Husam Alwan, Jon Read, Louise Goodwin, Alan Lau, Kay Eckersley, Willem M. Nissink
Publikováno v:
Molecular Cancer Therapeutics. 14:C59-C59
Human mutT homolog MTH1 (also known as NUDT1) is a purine nucleoside triphosphatase which hydrolyses oxidised nucleotides (8-oxo-dGTP and 2-OH-dATP) into mono-phosphate forms to prevent these damaged bases from being incorporated into DNA. Recent stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59273dad85dcc2febfa20a93b5ab361f
https://doi.org/10.1158/1535-7163.targ-15-c59
https://doi.org/10.1158/1535-7163.targ-15-c59
Autor:
John Hennam, Kay Eckersley, David Tonge, Ian Lee, Edge Michael Derek, John E. Fitton, S J East, Ian M. Hardern, Adrian Shufflebotham, Cheryl L. Forder, David C. Blakey, Anthony Slater
Publikováno v:
Protein Engineering Design and Selection. 11:1229-1234
Variants of human pancreatic carboxypeptidase B (HCPB), with specificity for hydrolysis of C-terminal glutamic acid and aspartic acid, were prepared by site-directed mutagenesis of the human gene and expressed in the periplasm of Escherichia coli. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce703fd9fe45d80932dc55f44c641d78
https://doi.org/10.1093/protein/11.12.1229
https://doi.org/10.1093/protein/11.12.1229
Autor:
Kerry Shea, Stephen T. Durant, Louise A. Griffiths, Emma E. Fairweather, Kay Eckersley, Dominic I. James, Ian D. Waddell, Donald J. Ogilvie, Paul P. Kelly, Mark J. O'Connor, Nicola Hamilton
Publikováno v:
James, D I, Durant, S, Eckersley, K, Fairweather, E, Griffiths, L A, Hamilton, N, Kelly, P, O'Connor, M, Shea, K, Waddell, I D & Ogilvie, D J 2016, ' An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells ', F1000Research, vol. 5, no. 736, pp. 736 . https://doi.org/10.12688/f1000research.8463.2
F1000Research
F1000Research
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d10f0ca05f9197c37ebfb9943933211
https://doi.org/10.12688/f1000research.8463.2
https://doi.org/10.12688/f1000research.8463.2
Autor:
Kay Eckersley, Helen Plant, Peter B. Simpson, David M. Andrews, Kevin Hudson, Lindsey Millard, Marian Preston, Ian M. Hardern, Thorsten Nowak, Jonathan D. Wrigley
Publikováno v:
Cancer Research. 71:4043-4043
Deubiquitinating enzymes (DUBs) represent promising opportunities for therapeutic intervention in oncology, and this study reports key information about the catalytic activity, assaying and inhibition of this novel enzyme class. The DUBs are protease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d38e04698582a133ffbd3b975adb63
https://doi.org/10.1158/1538-7445.am2011-4043
https://doi.org/10.1158/1538-7445.am2011-4043