Zobrazeno 1 - 10
of 554
pro vyhledávání: '"Kay E, Davies"'
Autor:
Katharina E. Meijboom, Emma R. Sutton, Eve McCallion, Emily McFall, Daniel Anthony, Benjamin Edwards, Sabrina Kubinski, Ines Tapken, Ines Bünermann, Gareth Hazell, Nina Ahlskog, Peter Claus, Kay E. Davies, Rashmi Kothary, Matthew J. A. Wood, Melissa Bowerman
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-25 (2022)
Abstract Background Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, leading to progressive m
Externí odkaz:
https://doaj.org/article/a0412765d08744319f58479db82da5ff
Autor:
Gauri Ang, Laurence A. Brown, Shu K. E. Tam, Kay E. Davies, Russell G. Foster, Paul J. Harrison, Rolf Sprengel, Vladyslav V. Vyazovskiy, Peter L. Oliver, David M. Bannerman, Stuart N. Peirson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Dysfunction of the glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit and deficits in synaptic plasticity are implicated in schizophrenia and sleep and circadian rhythm disruption. To investigate th
Externí odkaz:
https://doaj.org/article/db96924aa90f4475ae84a2e870b1ccac
Autor:
Simon Guiraud, Kay E Davies
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 8, Pp 1317-1320 (2019)
Skeletal muscle has an extraordinary capacity to regenerate after injury and trauma. The muscle repair mechanism is a complex process orchestrated by multiple steps. In neuromuscular disorders such as Duchenne muscular dystrophy (DMD), the pathologic
Externí odkaz:
https://doaj.org/article/fd8bc6aed37f4e12a73bf4195dac26ce
Autor:
Tahnee L. Kennedy, Simon Guiraud, Ben Edwards, Sarah Squire, Lee Moir, Arran Babbs, Guy Odom, Diane Golebiowski, Joel Schneider, Jeffrey S. Chamberlain, Kay E. Davies
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 92-105 (2018)
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by mutations in the dystrophin gene. DMD boys are wheelchair-bound around 12 years and generally survive into their twenties. There is currently no effective treatment exc
Externí odkaz:
https://doaj.org/article/b4cdbb1c898240c9ae805bf8b86d8caa
Autor:
Laura C.D. Pomatto, Patrick Y. Sun, Kelsi Yu, Sandhyarani Gullapalli, Conscience P. Bwiza, Christina Sisliyan, Sarah Wong, Hongqiao Zhang, Henry Jay Forman, Peter L. Oliver, Kay E. Davies, Kelvin J.A. Davies
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
The Nrf2 signal transduction pathway plays a major role in adaptive responses to oxidative stress and in maintaining adaptive homeostasis, yet Nrf2 signaling undergoes a significant age-dependent decline that is still poorly understood. We used mouse
Externí odkaz:
https://doaj.org/article/8016c2b7c2704af19c25f7c92de5e5fb
Autor:
Maria Chatzopoulou, Daniel Conole, Enrico Emer, Jessica A. Rowley, Nicky J. Willis, Sarah E. Squire, Becky Gill, Steve Brough, Francis X. Wilson, Graham M. Wynne, Stephen G. Davies, Kay E. Davies, Angela J. Russell
Publikováno v:
Bioorganicmedicinal chemistry. 69
A therapeutic approach that holds the potential to treat all Duchenne muscular dystrophy (DMD) patient populations is utrophin modulation. Ezutromid, a first generation utrophin modulator which was later found to act via antagonism of the arylhydroca
Autor:
Tonya N. Taylor, Dawid Potgieter, Sabina Anwar, Steven L. Senior, Stephanie Janezic, Sarah Threlfell, Brent Ryan, Laura Parkkinen, Thierry Deltheil, Milena Cioroch, Achilleas Livieratos, Peter L. Oliver, Katie A. Jennings, Kay E. Davies, Olaf Ansorge, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 193-207 (2014)
Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein. Approximately 5–10% of
Externí odkaz:
https://doaj.org/article/f910c68bfb0c420eafef94caca99d3db
Autor:
Kay E. Davies, Vratko Himič
Publikováno v:
European Journal of Human Genetics
Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle-wasting disorder that is caused by a lack of functional dystrophin, a cytoplasmic protein necessary for the structural integrity of muscle. As variants in the dystrophin gene lead to
Autor:
Stephen G. Davies, Angela J. Russell, Enrico Emer, Sarah E. Squire, Maria Chatzopoulou, Francis Xavier Wilson, Lee Moir, Anne-Sophie Casagrande, Kay E. Davies, Jessica A. Rowley, Graham Michael Wynne, Cristina Lecci, Shawn Harriman
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utrophin modulation is a disease-modifying therapeutic strategy for Duchenne muscular dystrophy that would be applicable to all patient populations. To improve the suboptimal profile of ezutromid, the first-in-class clinical candida
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi