Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Kay Diederichs"'
Autor:
Yizhi Yuan, Florian M. Stumpf, Lisa A. Schlor, Olivia P. Schmidt, Philip Saumer, Luisa B. Huber, Matthias Frese, Eva Höllmüller, Martin Scheffner, Florian Stengel, Kay Diederichs, Andreas Marx
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
RNA ligases are present across all forms of life. Here, the hitherto uncharacterised human protein C12orf29 was identified as a human enzyme promoting RNA ligation between 5′-PO4 and 3′-OH termini. This data provides the groundwork for establishi
Externí odkaz:
https://doaj.org/article/b4697e732f064db69887d55cb4ab9c94
Autor:
Thomas Zacharchenko, Till Dorendorf, Nicolas Locker, Evert Van Dijk, Anja Katzemich, Kay Diederichs, Belinda Bullard, Olga Mayans
Publikováno v:
Open Biology, Vol 13, Iss 4 (2023)
Obscurins are large filamentous proteins with crucial roles in the assembly, stability and regulation of muscle. Characteristic of these proteins is a tandem of two C-terminal kinase domains, PK1 and PK2, that are separated by a long intrinsically di
Externí odkaz:
https://doaj.org/article/7c1bd945c36547c1af49473a13231fe1
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5409-5419 (2022)
Sequence comparison is critical for the functional assignment of newly identified protein genes. As uncharacterized protein sequences accumulate, there is an increasing need for sensitive tools for their classification. Here, we present a novel multi
Externí odkaz:
https://doaj.org/article/ee9f6d605da94a7fb66bc9d8cd0bdb8b
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 681-692 (2020)
Crystallographic resolution is a key characteristic of diffraction data and represents one of the first decisions an experimenter has to make in data evaluation. Conservative approaches to the high-resolution cutoff determination are based on a numbe
Externí odkaz:
https://doaj.org/article/ede5abe79d5648118957d33ecb68469c
Autor:
Shibom Basu, Vincent Olieric, Filip Leonarski, Naohiro Matsugaki, Yoshiaki Kawano, Tomizaki Takashi, Chia-Ying Huang, Yusuke Yamada, Laura Vera, Natacha Olieric, Jerome Basquin, Justyna A. Wojdyla, Oliver Bunk, Kay Diederichs, Masaki Yamamoto, Meitian Wang
Publikováno v:
IUCrJ, Vol 6, Iss 3, Pp 373-386 (2019)
Native single-wavelength anomalous dispersion (SAD) is an attractive experimental phasing technique as it exploits weak anomalous signals from intrinsic light scatterers (Z < 20). The anomalous signal of sulfur in particular, is enhanced at long wave
Externí odkaz:
https://doaj.org/article/5ab92370c5b44931a45ad0f4b509e8f6
Autor:
Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily C. Tjon, Alejandro Buschiazzo, Ming Lei, Chris Botka, James Withrow, David Neau, Kanagalaghatta Rajashankar, Karen S. Anderson, Richard H. Baxter, Stephen C. Blacklow, Titus J. Boggon, Alexandre M. J. J. Bonvin, Dominika Borek, Tom J. Brett, Amedeo Caflisch, Chung-I Chang, Walter J. Chazin, Kevin D. Corbett, Michael S. Cosgrove, Sean Crosson, Sirano Dhe-Paganon, Enrico Di Cera, Catherine L. Drennan, Michael J. Eck, Brandt F. Eichman, Qing R. Fan, Adrian R. Ferré-D'Amaré, J. Christopher Fromme, K. Christopher Garcia, Rachelle Gaudet, Peng Gong, Stephen C. Harrison, Ekaterina E. Heldwein, Zongchao Jia, Robert J. Keenan, Andrew C. Kruse, Marc Kvansakul, Jason S. McLellan, Yorgo Modis, Yunsun Nam, Zbyszek Otwinowski, Emil F. Pai, Pedro José Barbosa Pereira, Carlo Petosa, C. S. Raman, Tom A. Rapoport, Antonina Roll-Mecak, Michael K. Rosen, Gabby Rudenko, Joseph Schlessinger, Thomas U. Schwartz, Yousif Shamoo, Holger Sondermann, Yizhi J. Tao, Niraj H. Tolia, Oleg V. Tsodikov, Kenneth D. Westover, Hao Wu, Ian Foster, James S. Fraser, Filipe R. N C. Maia, Tamir Gonen, Tom Kirchhausen, Kay Diederichs, Mercè Crosas, Piotr Sliz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it cou
Externí odkaz:
https://doaj.org/article/72383da3679147f9a2668c703d709d2e
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188005 (2017)
Archaeal B-family polymerases drive biotechnology by accepting a wide substrate range of chemically modified nucleotides. By now no structural data for archaeal B-family DNA polymerases in a closed, ternary complex are available, which would be the b
Externí odkaz:
https://doaj.org/article/d582794c8b6d439da59666c99529901b
Autor:
Sandra Postel, Daniel Deredge, Daniel A Bonsor, Xiong Yu, Kay Diederichs, Saskia Helmsing, Aviv Vromen, Assaf Friedler, Michael Hust, Edward H Egelman, Dorothy Beckett, Patrick L Wintrode, Eric J Sundberg
Publikováno v:
eLife, Vol 5 (2016)
Flagella are crucial for bacterial motility and pathogenesis. The flagellar capping protein (FliD) regulates filament assembly by chaperoning and sorting flagellin (FliC) proteins after they traverse the hollow filament and exit the growing flagellum
Externí odkaz:
https://doaj.org/article/bee7c0a8aa6d4f5a84b1d0eee2a39ce4
Autor:
Thomas Eicher, Markus A Seeger, Claudio Anselmi, Wenchang Zhou, Lorenz Brandstätter, François Verrey, Kay Diederichs, José D Faraldo-Gómez, Klaas M Pos
Publikováno v:
eLife, Vol 3 (2014)
Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods
Externí odkaz:
https://doaj.org/article/5381a1a21a394137af37560d2520b895
Publikováno v:
Journal of Muscle Research and Cell Motility.
The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that support thick filament assembly. It also has a demonstrated link to human disease. Despite its functio