Výsledky vyhledávání

Claudin 5 Expression in Mouse Seminiferous Epithelium Is Dependent upon the Transcription Factor Ets Variant 5 and Contributes to Blood-Testis Barrier Function1

Autor: Gaurav Tyagi, Liz Simon, Marie Claude Hofmann, Paul S. Cooke, Kenneth M. Murphy, Kay Carnes, Carla M.K. Morrow, Rex A. Hess

Publikováno v: Biology of Reproduction. 81:871-879

The blood-testis barrier (BTB) is formed by tight junctions between Sertoli cells. Results of previous studies suggested that the barrier is deficient in ets variant 5 (ETV5) gene-deleted mice; therefore, microarray data were examined for changes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cdfef5f3f91be2755b4a899028ffdd
https://doi.org/10.1095/biolreprod.109.077040

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Loss of Etv5 Decreases Proliferation and RET Levels in Neonatal Mouse Testicular Germ Cells and Causes an Abnormal First Wave of Spermatogenesis1

Autor: Kenneth M. Murphy, Gail C. Ekman, Chris E. Hostetler, Natalia V. Kostereva, Daryl D. Meling, Marie Claude Hofmann, Kay Carnes, Gaurav Tyagi, Michael D. Griswold, Paul S. Cooke, Carla M.K. Morrow, Rex A. Hess

Publikováno v: Biology of Reproduction. 81:258-266

Mice that are ets variant gene 5 (ETV5) null (Etv5 � /� ) undergo the first wave of spermatogenesis but lose all spermatogonial stem cells (SSCs) during this time. The SSC loss in Etv5 � /� mice begins during the neonatal period, suggesting a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::362d736f7c41738e9b312a230dbf9195
https://doi.org/10.1095/biolreprod.108.075200

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Loss of polyadenylation protein τCstF-64 causes spermatogenic defects and male infertility

Autor: Christopher L. Small, Brinda Dass, Bin Tian, Michael D. Griswold, Kay Carnes, Steve Tardif, Rex A. Hess, Ji Yeon Park, Clinton C. MacDonald, Harry M. Weitlauf

Publikováno v: Proceedings of the National Academy of Sciences. 104:20374-20379

Polyadenylation, the process of eukaryotic mRNA 3′ end formation, is essential for gene expression and cell viability. Polyadenylation of male germ cell mRNAs is unusual, exhibiting increased alternative polyadenylation, decreased AAUAAA polyadenyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a62d555e91493df2d0a9e2a8ffa2362
https://doi.org/10.1073/pnas.0707589104

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FK506, a Calcineurin Inhibitor, Prevents Cadmium-Induced Testicular Toxicity in Mice

Autor: Hooman Allayee, Haiyan Chen, Aldons J. Lusis, Xiaoyan Liao, Wendie A. Robbins, Michael D. Collins, David N. Hovland, Grace S. Lee, Lisa J. Martin, Kay Carnes, Rex A. Hess, Diana Mouhan Shih

Publikováno v: Toxicological Sciences. 100:474-485

Cadmium, a ubiquitous environmental contaminant, damages several major organs in humans and other mammals. The molecular mechanisms for damage are not known. At high doses (5 mg/kg cadmium chloride or higher), testicular damage in mice, rats, and oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d2c4fc152871d755b8554acce6a93d
https://doi.org/10.1093/toxsci/kfm229

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Proteasome Activator PA200 Is Required for Normal Spermatogenesis

Autor: Kay Carnes, Ryan T. Evans, Isaiah R. Turnbull, J. Michael White, Rex A. Hess, Ching-Yu Huang, Barry P. Sleckman, Bernard Khor, Andrea L. Bredemeyer, Leonard B. Maggi, Laura M. Walker

Publikováno v: Molecular and Cellular Biology. 26:2999-3007

The PA200 proteasome activator is a broadly expressed nuclear protein. Although how PA200 normally functions is not fully understood, it has been suggested to be involved in the repair of DNA double-strand breaks (DSBs). The PA200 gene (Psme4) is com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d2ab1a17801a3cbf8e60c4056ec097
https://doi.org/10.1128/mcb.26.8.2999-3007.2006

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ERM is required for transcriptional control of the spermatogonial stem cell niche

Autor: Kay Carnes, John A. Hassell, Hyunjung Jade Lim, Vadim Grigura, Chen Chen, Marie Claude Hofmann, Theresa L. Murphy, Rex A. Hess, Kenneth M. Murphy, Varadaraj Chandrashekar, Natasza A. Kurpios, Wenjun Ouyang, Silvia Arber, Guang Quan Zhao, Qing Zhou, Alec M. Cheng

Publikováno v: Nature. 436:1030-1034

Division of spermatogonial stem cells1 produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d62d23edbacb70db6cb7b4a456e10d
https://doi.org/10.1038/nature03894

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Aquaporin-1 and −9 are differentially regulated by oestrogen in the efferent ductule epithelium and initial segment of the epididymis

Autor: Luiz R. França, Cleida A. Oliveira, Kay Carnes, Louis Hermo, Rex A. Hess

Publikováno v: Biology of the Cell. 97:385-395

Background information. Efferent ductules reabsorb more than 90% of the rete testis fluid, a process that involves ion transporters and AQP (aquaporin) water channels. Oestrogen has been shown to modulate the expression of the ion transporters involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8fbe99ff46636fea8faad07f96ed76
https://doi.org/10.1042/bc20040078

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Ductuli efferentes of the male Golden Syrian hamster reproductive tract

Autor: Kay Carnes, James Ford, Rex A. Hess

Efferent ductules are responsible for the transportation of spermatozoa from the testis to the epididymis and their epithelium is responsible for the reabsorption of over 90% of the luminal fluid. The purpose of this research was to characterize the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2bac017842c9a2f31ebb6b6d5d07cc
https://europepmc.org/articles/PMC4069219/

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