Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kay Brickmann"'
Autor:
Michael O'sullivan, Kay Brickmann, Peter Bach, Jonas Boström, Darren Martin Harvey, Robert D. Groneberg, J.J.J. van Giezen, Fredrik Zetterberg
Publikováno v:
European Journal of Medicinal Chemistry. 65:360-375
The present paper describes the development of a new series of P2Y12 receptor antagonists based on our previously reported piperazinyl urea series 1 (IC50 binding affinity = 0.33 μM, aq solubility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b94cca81fda0127b84efce015bc277b8
https://doi.org/10.1016/j.ejmech.2013.04.007
https://doi.org/10.1016/j.ejmech.2013.04.007
Autor:
J.J.J. van Giezen, Jonas Boström, Kay Brickmann, Fredrik Zetterberg, Ragnar Hovland, Peter Bach, Asim K. Ray, Annika U. Petersson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2877-2881
A novel series of P2Y12 antagonists for development of drugs within the antiplatelet area is presented. The synthesis of the piperazinyl-pyridine urea derivatives and their structure–activity relationships (SAR) are described. Several compounds sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad2e1acede95baa24e42e9dedb14752
https://doi.org/10.1016/j.bmcl.2011.03.088
https://doi.org/10.1016/j.bmcl.2011.03.088
Publikováno v:
Tetrahedron. 62:10937-10944
A synthetic route to a 2,4-disubstituted pyridine as a potential β-strand mimetic has been developed and applied in the synthesis of a tripeptidomimetic of Leu-Gly-Gly. The pyridine scaffold replac ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0cd24e9ff98920890d1a22e4b5564d6
https://doi.org/10.1016/j.tet.2006.08.080
https://doi.org/10.1016/j.tet.2006.08.080
Publikováno v:
Liebigs Annalen. 1996:457-471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cbf3776a0fd0fdae1f217df0843d556
https://doi.org/10.1002/jlac.199619960406
https://doi.org/10.1002/jlac.199619960406
Publikováno v:
The Journal of Organic Chemistry. 69:3500-3508
A beta-turn mimetic in which the four amino acids of a beta-turn have been replaced by a 10-membered ring has been designed, synthesized, and subjected to conformational studies. In the mimetic, the intramolecular CO(i)-HN(i)(+3) hydrogen bond that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebb663903d9b2788b2a39b319ec3380
https://doi.org/10.1021/jo0356863
https://doi.org/10.1021/jo0356863
Autor:
Jan Kihlberg, Kjell Ekholm, ZhongQing Yuan, Birgitta Johansson, and Anders Nilsson, Ingmar Sethson, Kay Brickmann, David Blomberg
Publikováno v:
Journal of Medicinal Chemistry. 45:2512-2519
Oxytocin is a neurohypophyseal peptide hormone that induces labor and lactation in mammals. An inverse gamma-turn mimetic corresponding to the tripeptide Ile-Val-Asn has been synthesized and incorporated instead of residues 3-5 of oxytocin to probe t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981ef1d62c6195aed16d42023567245a
https://doi.org/10.1021/jm0110744
https://doi.org/10.1021/jm0110744
Publikováno v:
Chemistry - A European Journal. 5:2241-2253
Peptidesecondarystructuremimetics should accurately imitate the desired backbone conformation, and synthetic routes to peptidomimetics should allow for flexible introduction of side chains with correct stereochemistry. Both criteria are met by the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801058229c2ab88a3305e6f15dba7165
https://doi.org/10.1002/(sici)1521-3765(19990802)5:8<2241::aid-chem2241>3.0.co
https://doi.org/10.1002/(sici)1521-3765(19990802)5:8<2241::aid-chem2241>3.0.co
Autor:
Peter, Bach, Jonas, Boström, Kay, Brickmann, J J J, van Giezen, Robert D, Groneberg, Darren M, Harvey, Michael, O'Sullivan, Fredrik, Zetterberg
Publikováno v:
European journal of medicinal chemistry. 65
The present paper describes the development of a new series of P2Y12 receptor antagonists based on our previously reported piperazinyl urea series 1 (IC50 binding affinity = 0.33 μM, aq solubility0.1 μM, microsomal CLint (HLM) ≥300 μM/min/mg). B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8fb19daa30b7cb2ccb198999edbc2305
https://pubmed.ncbi.nlm.nih.gov/23747805
https://pubmed.ncbi.nlm.nih.gov/23747805
Publikováno v:
Chemische Berichte. 127:1949-1957
The nBuLi-induced tin/lithium exchange reactions of the di-astereomeric γ-[(methoxyethoxy)methoxy]-]α-(tributylstannyl) sulfides anti- and syn-8 delivered the α-(lithioalkyl) benzyl sulfides anti- and syn-11, respectively. Within 1 h at -78°C, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::062c9b419393aa11c98c1c2fe7503d1c
https://doi.org/10.1002/cber.19941271019
https://doi.org/10.1002/cber.19941271019
Autor:
Emre M. Isin, David Blomberg Saitton, Eric Wellner, Rutger H. A. Folmer, Pernilla Ståhlberg, Kay Brickmann, Volker Schnecke, Öjvind Davidsson, Christoffer Bengtsson, Lars-Olof Larsson, Stefan Hallén, Pernilla Sörme, Hong Wan, Kenth Hallberg, Linda Öster, Ragnar Hovland, Lars Löfgren, Alleyn T. Plowright, Bengt Kull, Tobias Noeske, Stefan Blaho, Petra Johannesson, Tomas Drmota, Kristina Nilsson, Johan Broddefalk, Nick Oakes
Publikováno v:
Bioorganicmedicinal chemistry. 19(10)
Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab801bb919b253dd5e5e3a7b103724d
https://pubmed.ncbi.nlm.nih.gov/21515056
https://pubmed.ncbi.nlm.nih.gov/21515056