Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kay B. Barnes"'
Autor:
Kay B. Barnes, Marc Bayliss, Carwyn Davies, Mark I. Richards, Thomas R. Laws, Andreas Vente, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Burkholderia mallei, the causative agent of glanders, is principally a disease of equines, although it can also infect humans and is categorized by the U.S. Centers for Disease Control and Prevention as a category B biological agent. Human cases of g
Externí odkaz:
https://doaj.org/article/65b439ec2bce445b839620f425b81232
Publikováno v:
Antibiotics, Vol 12, Iss 7, p 1096 (2023)
This study determined the in vitro activity of finafloxacin against panels of bacterial strains, representative of those associated with infection in cystic fibrosis patients and predominately isolated from clinical cases of respiratory disease. Many
Externí odkaz:
https://doaj.org/article/d27cfcc8b3da418f8ae701b4b32bf37d
Autor:
Kay B. Barnes, Mark I. Richards, Gary Burgess, Stuart J. Armstrong, Christine Bentley, Thomas C. Maishman, Thomas R. Laws, Michelle Nelson, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei. Doxycycline was down-selected from a panel of antibiotics evaluated in vitro a
Externí odkaz:
https://doaj.org/article/e6706cff0d9d4c09827642bcea38ae7d
Autor:
Adam O. Whelan, Ian Cooper, Nicola Ooi, David Orr, Kevin Blades, James Kirkham, Amanda Lyons, Kay B. Barnes, Mark I. Richards, Anne-Marie Salisbury, Mark Craighead, Sarah V. Harding
Publikováno v:
Antibiotics, Vol 12, Iss 6, p 983 (2023)
Antimicrobial resistance is a global issue, and the investigation of alternative therapies that are not traditional antibiotics are warranted. Novel bacterial type II topoisomerase inhibitors (NBTIs) have recently emerged as a novel class of antibiot
Externí odkaz:
https://doaj.org/article/6d05f97764de41768e12f6520ccf2f5f
Autor:
Michelle Nelson, Kay B. Barnes, Carwyn H. Davies, Christopher K. Cote, J. Matthew Meinig, Sergei S. Biryukov, David N. Dyer, Ondraya Frick, Henry Heine, Denise A. Pfefferle, Amanda Horstman-Smith, Julie Barbaras, Sarah V. Harding
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 506 (2023)
Burkholderia pseudomallei, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis is complex, requiring lengthy antibiotic regimens, which can result in the relapse of the
Externí odkaz:
https://doaj.org/article/c25b9392bed3404bb724de9c85736d57
Autor:
M. Gill Hartley, Isobel H. Norville, Mark I. Richards, Kay B. Barnes, Kevin R. Bewley, Julia Vipond, Emma Rayner, Andreas Vente, Stuart J. Armstrong, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Finafloxacin is a novel fluoroquinolone with optimal antibacterial activity in low pH environments, therefore offering a therapeutic advantage over some traditional antibiotics, in treating bacterial infections associated with acidic foci. Coxiella b
Externí odkaz:
https://doaj.org/article/f4f2e56b2dbc445d90035502bac07138
Autor:
Thomas R. Laws, Kay B. Barnes, Dominic C. Jenner, Alejandro Núñez, Mark I. Richards, Joanne E. Thwaite, Andreas Vente, David Rushton, Michelle Nelson, Sarah V. Harding
Publikováno v:
Antibiotics, Vol 11, Iss 10, p 1442 (2022)
Burkholderia pseudomallei is the causative agent of melioidosis, a multifaceted disease. A proportion of the mortality and morbidity reported as a result of infection with this organism may be due to the premature cessation of antibiotic therapy typi
Externí odkaz:
https://doaj.org/article/36d0b3fd7c504de8a03a4d84ca53a73a
Autor:
Christopher H. Jenkins, Russell Wallis, Natalie Allcock, Kay B. Barnes, Mark I. Richards, Joss M. Auty, Edouard E. Galyov, Sarah V. Harding, Galina V. Mukamolova
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Burkholderia pseudomallei is the causative agent of the tropical disease melioidosis. Its genome encodes an arsenal of virulence factors that allow it, when required, to switch from a soil dwelling bacterium to a deadly intracellular pathoge
Externí odkaz:
https://doaj.org/article/8b508a7a185a44429f883627df4c76f9
Autor:
Kay B. Barnes, Karleigh A. Hamblin, Mark I. Richards, Thomas R. Laws, Andreas Vente, Helen S. Atkins, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The efficacy of the novel fluoroquinolone finafloxacin was evaluated as a potential therapeutic in vitro and in vivo, following an intranasal infection of Francisella tularensis strain SchuS4 in BALB/c mice. We demonstrated that short treatment cours
Externí odkaz:
https://doaj.org/article/009529c55e954f5595493ff386d79cf6
Disulfiram, an alcohol dependence therapy, can inhibit the in vitro growth of Francisella tularensis
Autor:
Helen S. Atkins, Helen C. Flick-Smith, José B. Pereira-Leal, Richard Hampson, Kay B. Barnes, Jaroslaw Surkont, Karleigh A. Hamblin, Sarah V. Harding
Publikováno v:
International Journal of Antimicrobial Agents. 54:85-88
Disulfiram (DSF) can help treat alcohol dependency by inhibiting aldehyde dehydrogenase (ALDH). Genomic analysis revealed that Francisella tularensis, the causative agent of tularemia, has lost all but one ALDH-like domain and that this domain retain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d697af8b1515e3a56917462ddcb61748
https://doi.org/10.1016/j.ijantimicag.2019.04.002
https://doi.org/10.1016/j.ijantimicag.2019.04.002