Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kay A. Lawton"'
Autor:
Walter E Gall, Kirk Beebe, Kay A Lawton, Klaus-Peter Adam, Matthew W Mitchell, Pamela J Nakhle, John A Ryals, Michael V Milburn, Monica Nannipieri, Stefania Camastra, Andrea Natali, Ele Ferrannini, RISC Study Group
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10883 (2010)
Insulin resistance is a risk factor for type 2 diabetes and cardiovascular disease progression. Current diagnostic tests, such as glycemic indicators, have limitations in the early detection of insulin resistant individuals. We searched for novel bio
Externí odkaz:
https://doaj.org/article/7cb34fc25490493d886572aefd77fb51
Autor:
Elizabeth Joseloff, Michael V. Milburn, Diana R. Wetmore, Kay A. Lawton, Marianne S. Muhlebach, John A. Ryals, Lining Guo, Wei Sha, Sara C. Bell
Publikováno v:
Pediatric Pulmonology. 49:463-472
Summary Background Cystic fibrosis (CF) is a multi-system disease affecting multiple organs and cells besides the respiratory system. Metabolomic profiling allows simultaneous detection of biochemicals originating from cells, organs, or exogenous ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73cbb7a17cd04ee53b6d4849c7e2073b
https://doi.org/10.1002/ppul.22859
https://doi.org/10.1002/ppul.22859
Publikováno v:
Obesity. 21:E561-E570
Objectives A spectrum of disorders including simple steatosis, nonalcoholic steatohepatitis, fibrosis, and cirrhosis is described by nonalcoholic fatty liver disease (NAFLD). With the increased prevalence of obesity, and consequently NAFLD, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec986c8cece02e54a7ca4a2b08eb4bda
https://doi.org/10.1002/oby.20440
https://doi.org/10.1002/oby.20440
Autor:
Jacob Wulff, Makoto Yamazaki, Kay A. Lawton, Michael V. Milburn, Naoya Masutomi, Naohisa Tsutsui, Danny C. Alexander, Manami Miyake, Hiroko Sato, John A. Ryals, Klaus-Peter Adam, Lining Guo
Publikováno v:
Toxicology and Applied Pharmacology. 268:79-89
Drug-induced liver injury (DILI) is a significant consideration for drug development. Current preclinical DILI assessment relying on histopathology and clinical chemistry has limitations in sensitivity and discordance with human. To gain insights on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f14273709084ad98f91be016b8f6e47
https://doi.org/10.1016/j.taap.2013.01.018
https://doi.org/10.1016/j.taap.2013.01.018
Autor:
Michael V. Milburn, Kay A. Lawton
Publikováno v:
Annual Review of Medicine. 64:291-305
Metabolomics, the global interrogation of the biochemical components in a biological sample, has become an important complement to genomics and proteomics to aid in the understanding of pathophysiology. Major advantages of metabolomics are the size o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20673c607b8fe73e60e9dbcc56eee154
https://doi.org/10.1146/annurev-med-061511-134747
https://doi.org/10.1146/annurev-med-061511-134747
Autor:
Matthew W. Mitchell, Kay A. Lawton, Walter Gall, Eric Button, James P. Hathorn, Andrea Natali, Michael V. Milburn, Pamela J Nakhle, Klaus-Peter Adam, Regis Perichon, Jeff Cobb, Ele Ferrannini
Publikováno v:
Journal of Diabetes Science and Technology. 7:100-110
Background: Insulin resistance (IR) can precede the dysglycemic states of prediabetes and type 2 diabetes mellitus (T2DM) by a number of years and is an early marker of risk for metabolic and cardiovascular disease. There is an unmet need for a simpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fedd501840772b81dfbb9a61da581bb
https://doi.org/10.1177/193229681300700112
https://doi.org/10.1177/193229681300700112
Autor:
Michael V. Milburn, Matthew W. Mitchell, Douglas P. Lee, Lining Guo, Joseph M. Pilewski, Elizabeth Joseloff, Diana R. Wetmore, Kay A. Lawton, John A. Ryals
Publikováno v:
The Journal of Biological Chemistry
Cystic fibrosis (CF) is a life-shortening disease caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. To gain an understanding of the epithelial dysfunction associated with CF mutations and discover biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd402bd5b91c3f28711e7718783f69bc
http://europepmc.org/articles/PMC2945545
http://europepmc.org/articles/PMC2945545
Autor:
Leslie M. Fischer, Steven H. Zeisel, Michael V. Milburn, Wei Jia, Kerry Ann Da Costa, Wei Sha, Kay A. Lawton, Alvin Berger
Publikováno v:
The FASEB Journal. 24:2962-2975
Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detecta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dda18d043b013cd87d8c222e524b888
https://doi.org/10.1096/fj.09-154054
https://doi.org/10.1096/fj.09-154054
Autor:
Klaus-Peter Adam, Jeff Cobb, Robert A. Elverson, Robert L. Wolfert, Margaret M. Sinnott, Eric Button, Andrea D. Eckhart, Bernadette Carr, Kay A. Lawton, Jacob Wulff, Regis Perichon, Matthew W. Mitchell, Ele Ferrannini
Publikováno v:
Journal of diabetes science and technology. 9(1)
Background: The oral glucose tolerance test (OGTT) is the only method to diagnose patients having impaired glucose tolerance (IGT), but its use has diminished considerably in recent years. Metabolomic profiling studies have identified a number of met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0cf561ece460d5d8bba59df5a2b931
https://pubmed.ncbi.nlm.nih.gov/25427966
https://pubmed.ncbi.nlm.nih.gov/25427966
Autor:
Kay A, Lawton, Meredith V, Brown, Danny, Alexander, Zhen, Li, Jacob E, Wulff, Robert, Lawson, Matt, Jaffa, Mike V, Milburn, John A, Ryals, Robert, Bowser, Merit E, Cudkowicz, James D, Berry, Robert H, Brown
Publikováno v:
Amyotrophic lateral sclerosisfrontotemporal degeneration. 15(5-6)
Our objective was to identify plasma biomarkers of ALS that can aid in distinguishing patients with ALS from those with disease mimics. In this multi-center study, plasma samples were collected from 172 patients recently diagnosed with ALS, 50 health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1be0a5bd2b4f1a860f80a7215bc71c
https://pubmed.ncbi.nlm.nih.gov/24984169
https://pubmed.ncbi.nlm.nih.gov/24984169