Zobrazeno 1 - 10
of 937
pro vyhledávání: '"Kay, Washington"'
Autor:
Jia Li, Alan J. Simmons, Caroline V. Hawkins, Sophie Chiron, Marisol A. Ramirez-Solano, Naila Tasneem, Harsimran Kaur, Yanwen Xu, Frank Revetta, Paige N. Vega, Shunxing Bao, Can Cui, Regina N. Tyree, Larry W. Raber, Anna N. Conner, Jennifer M. Pilat, Justin Jacobse, Kara M. McNamara, Margaret M. Allaman, Gabriella A. Raffa, Alain P. Gobert, Mohammad Asim, Jeremy A. Goettel, Yash A. Choksi, Dawn B. Beaulieu, Robin L. Dalal, Sara N. Horst, Baldeep S. Pabla, Yuankai Huo, Bennett A. Landman, Joseph T. Roland, Elizabeth A. Scoville, David A. Schwartz, M. Kay Washington, Yu Shyr, Keith T. Wilson, Lori A. Coburn, Ken S. Lau, Qi Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Crohn’s disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 cells from 170 specimens across 83 patients, we identify a di
Externí odkaz:
https://doaj.org/article/0ba81d63e38741479e8c66302f19cf18
Autor:
Kateryna Nabukhotna, Shannon L Kordus, John A Shupe, Rubén Cano Rodríguez, Anna Smith, Julia K Bohannon, M Kay Washington, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1012568 (2024)
Clostridioides difficile is a spore-forming pathogen and the most common cause of healthcare-associated diarrhea and colitis in the United States. Besides producing the main virulence factors, toxin A (TcdA) and toxin B (TcdB), many of the common cli
Externí odkaz:
https://doaj.org/article/e4b4bb5a738b4efeab523e61d2c2ba67
Autor:
Alain P. Gobert, Jordan Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Caroline V. Hawkins, Kamery J. Williams, Alberto G. Delagado, Raghavendra G. Mirmira, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33838- (2024)
Hypusine is an amino acid synthesized by the enzyme deoxyhypusine synthase (DHPS). It is critical for the activity of eukaryotic translation initiation factor 5A (EIF5A). We reported that hypusination i) in macrophages supports the innate response to
Externí odkaz:
https://doaj.org/article/02fd8b1c2fd24f64a472e36bac86f199
Autor:
Yvonne L. Latour, Kara M. McNamara, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Mohammad Asim, Kamery J. Williams, Caroline V. Hawkins, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The intestinal immune response is crucial in maintaining a healthy gut, but the enhanced migration of macrophages in response to pathogens is a major contributor to disease pathogenesis. Integrins are ubiquitously expressed cellular receptor
Externí odkaz:
https://doaj.org/article/fb0bf8276c3646598c802c501115e29e
Autor:
Kasey M. Schalich, Matthew A. Buendia, Harpreet Kaur, Yash A. Choksi, M. Kay Washington, Gabriela S. Codreanu, Stacy D. Sherrod, John A. McLean, Richard M. Peek, Jr., Sari A. Acra, Steven D. Townsend, Fang Yan
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTObservational evidence suggests that human milk oligosaccharides (HMOs) promote the growth of commensal bacteria in early life and adulthood. However, the mechanisms by which HMOs benefit health through modulation of gut microbial homeostasis
Externí odkaz:
https://doaj.org/article/b1067dced790480e8612a3e92377e026
Autor:
Justin Jacobse, Jennifer M. Pilat, Jing Li, Rachel E. Brown, Aaron Kwag, Matthew A. Buendia, Yash A. Choksi, M. Kay Washington, Christopher S. Williams, Nicholas O. Markham, Sarah P. Short, Jeremy A. Goettel
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
IntroductionThe pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling in CRC remain unknown. One of the cell types that highly expres
Externí odkaz:
https://doaj.org/article/6947d7d90a02414ea9d2f0a99aacdfe4
Autor:
Harpreet Kaur, Syed Azmal Ali, Sarah P. Short, Christopher S. Williams, Jeremy A. Goettel, M. Kay Washington, Richard M. Peek, Sari A. Acra, Fang Yan
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTSeveral probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is ori
Externí odkaz:
https://doaj.org/article/fbd498869d1e4dc9a38573f75067729d
Autor:
F. Christopher Peritore-Galve, Izumi Kaji, Anna Smith, Lauren M. Walker, John A. Shupe, M. Kay Washington, Holly M. Scott Algood, Pradeep K. Dudeja, James R. Goldenring, D. Borden Lacy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTBackground & Aim Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. Howe
Externí odkaz:
https://doaj.org/article/24d8cbb83eb34a299947e37b96105dfe
Autor:
Justin Jacobse, Zaryab Aziz, Lili Sun, Jasmine Chaparro, Jennifer M. Pilat, Aaron Kwag, Matthew Buendia, Mae Wimbiscus, Motomi Nasu, Tsuyoshi Saito, Shinji Mine, Hajime Orita, Frank Revetta, Sarah P. Short, M. Kay Washington, Girish Hiremath, Michael K. Gibson, Lori A. Coburn, Tatsuki Koyama, Jeremy A. Goettel, Christopher S. Williams, Yash A. Choksi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 961-983 (2023)
Background and Aims: Eosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), as their role in ESCC is unknown. Methods: Eo
Externí odkaz:
https://doaj.org/article/535c54c9fb8d4824bb0c1da6e4ad6d4b
Autor:
Zohreh Sharifkhodaei, Cambrian Y. Liu, Nandini Girish, Ying Huang, Shivesh Punit, M. Kay Washington, D. Brent Polk
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107829- (2023)
Summary: Colonic epithelial repair is a key determinant of health. Repair involves changes in epithelial differentiation, an extensive proliferative response, and upregulation of regeneration-associated “fetal-like” transcripts, including Ly6a (S
Externí odkaz:
https://doaj.org/article/a6237c974c87456abb13df0d38eec0a5