Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics

Autor: Tom M. Quinn, Erin E. Gaughan, Annya Bruce, Jean Antonelli, Richard O'Connor, Feng Li, Sarah McNamara, Oliver Koch, Claire MacKintosh, David Dockrell, Timothy Walsh, Kevin G. Blyth, Colin Church, Jürgen Schwarze, Cecilia Boz, Asta Valanciute, Matthew Burgess, Philip Emanuel, Bethany Mills, Giulia Rinaldi, Gareth Hardisty, Ross Mills, Emily Gwyer Findlay, Sunny Jabbal, Andrew Duncan, Sinéad Plant, Adam D.L. Marshall, Irene Young, Kay Russell, Emma Scholefield, Alastair F. Nimmo, Islom B. Nazarov, Grant C. Churchill, James S.O. McCullagh, Kourosh H. Ebrahimi, Colin Ferrett, Kate Templeton, Steve Rannard, Andrew Owen, Anne Moore, Keith Finlayson, Manu Shankar-Hari, John Norrie, Richard A. Parker, Ahsan R. Akram, Daniel C. Anthony, James W. Dear, Nik Hirani, Kevin Dhaliwal

Publikováno v: EBioMedicine, Vol 76, Iss , Pp 103856- (2022)

Summary: Background: Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is nafamostat mesylate. Methods: We present the

Externí odkaz: https://doaj.org/article/30aabc317f5544bcb011f0340db28762

How to prove Hume’s Law

Autor: Gillian Kay Russell

This paper proves a precisification of Hume’s Law—the thesis that one cannot get an ought from an is—as an instance of a more general theorem which establishes several other philosophically interesting, though less controversial, barriers to lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce58949485f8607ac9ec1fa847b10b8
https://acuresearchbank.acu.edu.au/item/8x47v/how-to-prove-hume-s-law

The Effects of Commonly Consumed Dietary Fibres on the Gut Microbiome and Its Fibre Fermentative Capacity in Adults with Inflammatory Bowel Disease in Remission

Autor: Konstantinos Gerasimidis, Ben Nichols, Mhairi McGowan, Vaios Svolos, Rodanthi Papadopoulou, Margarita Kokkorou, Martina Rebull, Teresita Bello Gonzalez, Richard Hansen, Richard Kay Russell, Daniel Richard Gaya

Publikováno v: Nutrients 14 (2022) 5
Nutrients; Volume 14; Issue 5; Pages: 1053
Nutrients, 14(5)

Introduction: It has been suggested that the gut microbiome of patients with inflammatory bowel disease (IBD) is unable to ferment dietary fibre. This project explored the in vitro effect of fibre fermentation on production of short-chain fatty acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5f20ae248661a4bde28057ee1347bf
https://research.wur.nl/en/publications/the-effects-of-commonly-consumed-dietary-fibres-on-the-gut-microb

The Interrelations of Musical Instruments, Musical Forms, and Cultural Systems in Africa

Autor: Wachsmann, Klaus P., Kay, Russell

Publikováno v: Technology and Culture, 1971 Jul 01. 12(3), 399-413.

Externí odkaz: https://www.jstor.org/stable/3102996

Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID Pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics

Autor: Oliver Koch, Andrew Duncan, Jean Antonelli, Timothy S. Walsh, Annya Bruce, Kay Russell, Colin Ferrett, Colin Church, James S. O. McCullagh, Jürgen Schwarze, Cecilia Boz, Giulia Rinaldi, Sinéad Plant, Gareth Hardisty, Anne Moore, Ahsan R. Akram, Kourosh Honarmand Ebrahimi, Sarah McNamara, Feng Li, Kevin G. Blyth, K. Dhaliwal, David H. Dockrell, Asta Valanciute, Ross Mills, Bethany Mills, Claire L. Mackintosh, Daniel C. Anthony, Tom Quinn, Steve P. Rannard, John Norrie, Irene Young, Keith Finlayson, Kate Templeton, Alastair F. Nimmo, Richard A. O’Connor, Erin Gaughan, Emma Scholefield, James W. Dear, Richard Parker, Andrew Owen, Philip Emanuel, Manu Shankar-Hari, Grant C. Churchill, Adam Marshall, Nik Hirani, Islom B. Nazarov, Matthew Burgess, Emily Gwyer Findlay, Sunny Jabball

Publikováno v: Quinn, T, Gaughan, E E, Bruce, A, Antonelli, J, O'Connor, R A, Li, F, McNamara, S, Koch, O, Mackintosh, C, Dockrell, D, Walsh, T, Blyth, K G, Church, C, Schwarze, J, Boz, C, Valanciute, A, Burgess, M, Emanuel, P, Mills, B, Rinaldi, G, Hardisty, G, Mills, R, Gwyer Findlay, E L, Jabbal, S, Duncan, A, Plant, S, Marshall, A D L, Young, I, Russell, K, Scholefield, E, Nimmo, A F, Nazarov, I B, Churchill, G C, McCullagh, J S O, Ebrahimi, K H, Ferrett, C, Templeton, K E, Rannard, S, Owen, A, Moore, A, Finlayson, K, Shankar-Hari, M, Akram, A R, Parker, R A, Dear, J W, Hirani, N & Dhaliwal, K 2022, ' Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2022.103856
EBioMedicine, Vol 76, Iss, Pp 103856-(2022)

Despite the success of vaccines and selected repurposed treatments, COVID-19 is likely to remain a global health problem and further chemotherapeutics are required. Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials without charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08984770a1c6b75fcf7ed0f83784327
https://doi.org/10.2139/ssrn.3958859