Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Kay, Perry"'
Autor:
Kwangkook Lee, Kay Perry, Mengyao Xu, Irva Veillard, Raj Kumar, Thapi Dharma Rao, Bo R Rueda, David R Spriggs, Oladapo O Yeku
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-15 (2024)
Abstract Background Mucin 16 (MUC16) overexpression is linked with cancer progression, metastasis, and therapy resistance in high grade serous ovarian cancer and other malignancies. The cleavage of MUC16 forms independent bimodular fragments, the she
Externí odkaz:
https://doaj.org/article/c005b33e38204f0e944434f359e1023e
Autor:
Zheng Liu, Pyung-Gang Lee, Nadja Krez, Kwok-ho Lam, Hao Liu, Adina Przykopanski, Peng Chen, Guorui Yao, Sicai Zhang, Jacqueline M. Tremblay, Kay Perry, Charles B. Shoemaker, Andreas Rummel, Min Dong, Rongsheng Jin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (HCE) in complex with it
Externí odkaz:
https://doaj.org/article/689e4b646d7b448d89b2317de1ca4c69
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Clostridioides difficile is one of the most common causes of antibiotic-associated diarrhea in developed countries. As key virulence factors of C. difficile, toxin A (TcdA) and toxin B (TcdB) act by glucosylating and inactivating Rho and Ras
Externí odkaz:
https://doaj.org/article/fe80ef6ff43f46aea6792bc69e36773c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for diseases associated with C. difficil
Externí odkaz:
https://doaj.org/article/a5ca8ffae52145f8b4b68f0d541fab48
Autor:
Kwok-Ho Lam, Jacqueline M Tremblay, Kay Perry, Konstantin Ichtchenko, Charles B Shoemaker, Rongsheng Jin
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010169 (2022)
Botulinum neurotoxins (BoNTs) are among the deadliest of bacterial toxins. BoNT serotype A and B in particular pose the most serious threat to humans because of their high potency and persistence. To date, there is no effective treatment for late pos
Externí odkaz:
https://doaj.org/article/6c287bf8f9a949e183f251c1c3d61537
Autor:
Fumin Shi, Jeannine M. Mendrola, Joshua B. Sheetz, Neo Wu, Anselm Sommer, Kelsey F. Speer, Jasprina N. Noordermeer, Zhong-Yuan Kan, Kay Perry, S. Walter Englander, Steven E. Stayrook, Lee G. Fradkin, Mark A. Lemmon
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109834- (2021)
Summary: WNTs play key roles in development and disease, signaling through Frizzled (FZD) seven-pass transmembrane receptors and numerous co-receptors including ROR and RYK family receptor tyrosine kinases (RTKs). We describe crystal structures and W
Externí odkaz:
https://doaj.org/article/0a50f419840142aeb7b781200e52336f
Autor:
Linfeng Gao, Kwok‐ho Lam, Shun Liu, Adina Przykopanski, Johanna Lübke, Ruifeng Qi, Maren Krüger, Maria B. Nowakowska, Katja Selby, François P. Douillard, Martin B. Dorner, Kay Perry, Miia Lindström, Brigitte G. Dorner, Andreas Rummel, Rongsheng Jin
Publikováno v:
FEBS Letters. 597:524-537
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7ec264226ff12ff30f87777f7d05f4
https://doi.org/10.1002/1873-3468.14576
https://doi.org/10.1002/1873-3468.14576
Autor:
Kwok-ho Lam, Jacqueline M. Tremblay, Edwin Vazquez-Cintron, Kay Perry, Celinia Ondeck, Robert P. Webb, Patrick M. McNutt, Charles B. Shoemaker, Rongsheng Jin
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2526-2539.e6 (2020)
Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of
Externí odkaz:
https://doaj.org/article/9b97bbbb254f433e82a523d6039fe9be
Autor:
Kwok-ho Lam, Zhuojun Guo, Nadja Krez, Tsutomu Matsui, Kay Perry, Jasmin Weisemann, Andreas Rummel, Mark E. Bowen, Rongsheng Jin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The translocation domain (HN) of Botulinum neurotoxins (BoNTs) mediates the delivery of the BoNT light chain (LC) into neuronal cytosol. Here the authors provide insights into HN membrane insertion by determining the crystal structure of BoNT/A1 HN a
Externí odkaz:
https://doaj.org/article/254881e40fb84f0690898f9dda9538c2
Autor:
Guorui Yao, Kwok-ho Lam, Jasmin Weisemann, Lisheng Peng, Nadja Krez, Kay Perry, Charles B. Shoemaker, Min Dong, Andreas Rummel, Rongsheng Jin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Antibody treatment is currently the only available countermeasure for botulism, a fatal illness caused by flaccid paralysis of muscles due to botulinum neurotoxin (BoNT) intoxication. Among the seven major serotypes of BoNT/A-G, BoNT/A poses
Externí odkaz:
https://doaj.org/article/28d488b3904246b2b17c6304fa26a9f6