Výsledky vyhledávání

Ratio encoding combinatorial libraries with stable isotopes and their utility in pharmaceutical research

Autor: Wagner, D. S., Markworth, C. J., Wagner, C. D., Frank Schoenen, Rewerts, C. E., Kay, B. K., Geysen, H. M.

Publikováno v: Scopus-Elsevier

Combinatorial libraries are an important tool for lead discovery in the pharmaceutical industry. Advances in high throughput screening coupled with combinatorial chemistry can significantly reduce the time to find lead compounds. A major difficulty i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d067bf316641bdd77c2a54c243c557f8
https://doi.org/10.2174/138620730103220120142733

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Akademický článek

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Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library

Autor: Sahu, A., Kay, B. K., John Lambris

Publikováno v: Scopus-Elsevier

We have screened a phage-displayed random peptide library for binding to C3b, the proteolytically activated form of complement component C3, and have identified a novel peptide that suppresses complement activation. This phage-displayed peptide bound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a329bd652da5287cf8db7686513d3c00
https://doi.org/10.4049/jimmunol.157.2.884

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Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2

Autor: Fowlkes, D. M., Sparks, A. B., Kay, B. K., Hoffman, N. G., Rider, J. E., Quillam, L. A.

Src homology 3 (SH3) domains are conserved protein modules 50-70 amino acids long found in a variety of proteins with important roles in signal transduction. These domains have been shown to mediate protein-protein interactions by binding short proli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb6cec75014c2ffac479f44d0968bad9

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Gene activation is required for developmentally programmed cell death

Autor: Kosz, L., Schwartz, L. M., Kay, B. K.

The intersegmental muscles of the tobacco hawkmoth Manduca sexta die during the 36-hr period after metamorphosis. The trigger for cell death is a fall in the ecdysteroid titer. Commitment of the intersegmental muscles to degenerate involves selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ecd07abd8a8c3ca3e73f965e708ce5b

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Akademický článek

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Periodical

Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways.

Autor: Adams, A, Thorn, J M, Yamabhai, M, Kay, B K, O'Bryan, J P

Publikováno v: Journal of Biological Chemistry; September 2000, Vol. 275 Issue: 35 p27414-20, 7p

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Periodical

Convergent evolution with combinatorial peptides

Autor: Kay, B. K., Kasanov, J., Knight, S., Kurakin, A.

Publikováno v: FEBS Letters; 2000, Vol. 480 Issue: 1 p55-62, 8p

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Periodical

Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells.

Autor: Hussain, N K, Yamabhai, M, Ramjaun, A R, Guy, A M, Baranes, D, O'Bryan, J P, Der, C J, Kay, B K, McPherson, P S

Publikováno v: Journal of Biological Chemistry; May 1999, Vol. 274 Issue: 22 p15671-7, 7p

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Periodical

The connection domain is implicated in metalloporphyrin binding and inhibition of HIV reverse transcriptase.

Autor: Argyris, E G, Vanderkooi, J M, Venkateswaran, P S, Kay, B K, Paterson, Y

Publikováno v: Journal of Biological Chemistry; January 1999, Vol. 274 Issue: 3 p1549-56, 8p

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