Optimized Immunostaining of Embryonic and Early Postnatal Mouse Brain Sections

Autor: Kawssar Harb, Michele Bertacchi, Michèle Studer

Publikováno v: Bio-Protocol, Vol 11, Iss 1 (2021)

The mammalian neocortex, the outer layer of the cerebrum and most recently evolved brain region, is characterized by its unique areal and laminar organization. Distinct cortical layers and areas can be identified by the protein expression of graded t

Externí odkaz: https://doaj.org/article/6667a8236ce546dab971c2fee2f3d90a

Author response: Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

Autor: Kawssar Harb, Melanie Richter, Nagammal Neelagandan, Elia Magrinelli, Hend Harfoush, Katrin Kuechler, Melad Henis, Irm Hermanns-Borgmeyer, Froylan Calderon de Anda, Kent Duncan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44eacc2d28fa29914a30b964aef5f2f9
https://doi.org/10.7554/elife.55199.sa2

Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications

Autor: Tao Sun, Céline S Nicolas, Nikita Lukianets, Mariel Pietri, Laura Frangeul, Michèle Studer, Guillaume Sandoz, Franck Grammont, Denis Jabaudon, Christian Alfano, Kawssar Harb, Elia Magrinelli

Publikováno v: eLife
eLife, 2016, ⟨10.7554/eLife.09531.020⟩
eLife, Vol 5 (2016)
eLife, Vol. 5 (2016) P. e09531
eLife, eLife Sciences Publication, 2016, ⟨10.7554/eLife.09531.020⟩

During cortical development, the identity of major classes of long-distance projection neurons is established by the expression of molecular determinants, which become gradually restricted and mutually exclusive. However, the mechanisms by which proj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd42e32c80ee5b170218162b92b34b4c
https://hal.science/hal-01292321

Morphological Analysis and Feature Extraction of Neurons from Mouse Cortices Multiscale 3D Microscopic Images

Autor: Eric Debreuve, Kawssar Harb, Alexis Zubiolo, Xavier Descombes, Michèle Studer

Publikováno v: Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:7466-9
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015)
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015), IEEE Engineering in Medicine and Biology Society (EMBS), Aug 2015, Milan, Italy. ⟨10.1109/EMBC.2015.7320118⟩
EMBC

International audience; In this paper, we propose a framework to analyze the morphology of mouse neurons in the layer V of the cortex from 3D microscopic images. We are given 8 sets of images, each of which is composed of a 10x image showing the whol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6509e138ff0c843b64bfcdebf0e81970
https://hal.inria.fr/hal-01176966

Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

Autor: Kawssar Harb, Melanie Richter, Nagammal Neelagandan, Elia Magrinelli, Hend Harfoush, Katrin Kuechler, Melad Henis, Irm Hermanns-Borgmeyer, Froylan Calderon de Anda, Kent Duncan

In the neocortex, functionally distinct areas process specific types of information. Area identity is established by morphogens and transcriptional master regulators, but downstream mechanisms driving area-specific neuronal specification remain uncle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22708100179aa761af503dd0210aba3e
https://infoscience.epfl.ch/record/293040