Mutation of APP Caspase Cleavage Site at Position D664 Does Not Affect Dendritic Spine Morphology in Mice

Autor: Kawakatsu, Yusuke

Publikováno v: Kawakatsu, Yusuke. (2014). Mutation of APP Caspase Cleavage Site at Position D664 Does Not Affect Dendritic Spine Morphology in Mice /. UC San Diego: Biology. Retrieved from: http://www.escholarship.org/uc/item/5742z3n9

The amyloid cascade hypothesis posits that Alzheimer's disease (AD) is driven by the production of A[beta] from the cleavage of the amyloid precursor protein (APP) by secretases. However, APP is also cleaved by caspases to release a toxic peptide ter

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