Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kavyashree Manjunath"'
Autor:
Vikrant Kumar, Puneeth Kumar Chunchagatta Lakshman, Thazhe Kootteri Prasad, Kavyashree Manjunath, Sneha Bairy, Akshaya S. Vasu, B. Ganavi, Subbarao Jasti, Neelagandan Kamariah
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23864- (2024)
Target-based discovery of first-in-class therapeutics demands an in-depth understanding of the molecular mechanisms underlying human diseases. Precise measurements of cellular and biochemical activities are critical to gain mechanistic knowledge of b
Externí odkaz:
https://doaj.org/article/db664869fa4c445ba01299e12ca67ed2
Autor:
Shahbaz Ahmed, Gopinath Chattopadhyay, Kavyashree Manjunath, Munmun Bhasin, Neelam Singh, Mubashir Rasool, Sayan Das, Varsha Rana, Neha Khan, Debarghya Mitra, Aparna Asok, Ramandeep Singh, Raghavan Varadarajan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The Mycobacterium tuberculosis genome harbours nine toxin-antitoxin (TA) systems of the mazEF family. These consist of two proteins, a toxin and an antitoxin, encoded in an operon. While the toxin has a conserved fold, the antitoxins are structurally
Externí odkaz:
https://doaj.org/article/c702b2a39b394e2fa11e604654d0febc
Autor:
Gopinath Chattopadhyay, Jayantika Bhowmick, Kavyashree Manjunath, Shahbaz Ahmed, Parveen Goyal, Raghavan Varadarajan
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010334 (2022)
Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue defects caused by diverse loss-of-function mutations. Such globa
Externí odkaz:
https://doaj.org/article/d704902dd2074373bf87b1ed3df308bd
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Accurate prediction of residue burial as well as quantitative prediction of residue-specific contributions to protein stability and activity is challenging, especially in the absence of experimental structural information. This is important for predi
Externí odkaz:
https://doaj.org/article/1a258e9bce3f4378a88b69ef10e4c26c
Autor:
Anshumali Mittal, Kavyashree Manjunath, Rajesh Kumar Ranjan, Sandeep Kaushik, Sujeet Kumar, Vikash Verma
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008762 (2020)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newly emerging, highly transmissible, and pathogenic coronavirus in humans that has caused global public health emergencies and economic crises. To date, millions of infections and tho
Externí odkaz:
https://doaj.org/article/ebaecffe24d14f4091913a2a3610cd70
Autor:
Kirti Vaishnavi, Nishant Saxena, Navjot Shah, Rumani Singh, Kavyashree Manjunath, M Uthayakumar, Shankar P Kanaujia, Sunil C Kaul, Kanagaraj Sekar, Renu Wadhwa
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44419 (2012)
BACKGROUND AND PURPOSE:Withanolides are naturally occurring chemical compounds. They are secondary metabolites produced via oxidation of steroids and structurally consist of a steroid-backbone bound to a lactone or its derivatives. They are known to
Externí odkaz:
https://doaj.org/article/e83ef72326714d8fa698f54b1c64b8f7
Autor:
Raghavan Varadarajan, Kavyashree Manjunath, Parveen Goyal, Jayantika Bhowmick, Shahbaz Ahmed, Gopinath Chattopadhyay
Publikováno v:
PLoS genetics. 18(8)
Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue defects caused by diverse loss-of-function mutations. Such globa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6193821f8b7cde40e55cf481c707e52c
https://pubmed.ncbi.nlm.nih.gov/36037221
https://pubmed.ncbi.nlm.nih.gov/36037221
Unlike globular proteins, mutational effects on the function of Intrinsically Disordered Proteins (IDPs) are not well-studied. Deep Mutational Scanning of a yeast surface displayed mutant library yields insights into sequence-function relationships i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccca47caf40a3ec2c7c7b476697f492b
https://doi.org/10.1101/2022.04.08.487678
https://doi.org/10.1101/2022.04.08.487678
Publikováno v:
Protein Sci
Mutations that affect protein binding to a cognate partner primarily occur either at buried residues or at exposed residues directly involved in partner binding. Distinguishing between these two categories based solely on mutational phenotypes is cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2cad2e20bfee98d6b11a457f0995de
https://doi.org/10.1101/2022.02.21.481196
https://doi.org/10.1101/2022.02.21.481196