Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Kavya Ramkumar"'
Autor:
Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Valerio Nardone, Salvatore Cappabianca, Immacolata Cozzolino, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Giulia Martini, Stefania Napolitano, Jing Wang, Lauren Averett Byers, Fortunato Ciardiello, Floriana Morgillo
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Despite the recent progress in the treatment and outcome of Non Small Cell Lung Cancer (NSCLC), immunotherapy has still significant limitations reporting a significant proportion of patients not benefiting from therapy, even in pa
Externí odkaz:
https://doaj.org/article/4d5ae18f30924a37828cfd4f27422b03
Autor:
Carminia Maria Della Corte, Morena Fasano, Vincenza Ciaramella, Flora Cimmino, Robert Cardnell, Carl M. Gay, Kavya Ramkumar, Lixia Diao, Raimondo Di Liello, Giuseppe Viscardi, Vincenzo Famiglietti, Davide Ciardiello, Giulia Martini, Stefania Napolitano, Concetta Tuccillo, Teresa Troiani, Erika Martinelli, Jing Wang, Lauren Byers, Floriana Morgillo, Fortunato Ciardiello
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-10 (2022)
Abstract Background We recently conducted Cetuximab-AVElumab-Lung (CAVE-Lung), a proof-of-concept, translational and clinical trial, to evaluate the combination of two IgG1 monoclonal antibodies (mAb): avelumab, an anti-PD-L1 drug, and cetuximab, an
Externí odkaz:
https://doaj.org/article/bf73de6b841a47699632ecd99243d1f4
Autor:
Kasey R. Cargill, C. Allison Stewart, Elizabeth M. Park, Kavya Ramkumar, Carl M. Gay, Robert J. Cardnell, Qi Wang, Lixia Diao, Li Shen, You-Hong Fan, Wai Kin Chan, Philip L. Lorenzi, Trudy G. Oliver, Jing Wang, Lauren A. Byers
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Introduction The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis and mitochondrial respiration. This duality o
Externí odkaz:
https://doaj.org/article/0736ef15a3794632870c3c21f1f36c7a
Autor:
Tyler Curiel, Lauren Byers, Yilun Deng, Alvaro Padron, Harshita Gupta, Anand Kornepati, Clare Murray, Ratna Vadlamudi, Barbara Avalos, Cody Rogers, Kavya Ramkumar, Zexuan Liu, Eloise Dray, Weixing Zhao, Patrick Sung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/00497fb3d9ef4db6af58b0fe95dbdcee
Autor:
Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura, Elizabeth Ziemke, Jeanne A. Stuckey, Si Li, Krishnapriya Chinnaswamy, Hiroyuki Otake, Bikash Debnath, Vladimir Yarovenko, Judith S. Sebolt-Leopold, Mats Ljungman, Nouri Neamati
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform overexpressed in several cancers that has been implicated in drug resistance. Here the authors identify a small molecule inhibitor of GSTO1 that effectively inhibits tumor growth in
Externí odkaz:
https://doaj.org/article/7431badb33544578ba6eb5990f3bb58e
Autor:
Kavya Ramkumar, Vladimir N. Yarovenko, Alexandra S. Nikitina, Igor V. Zavarzin, Mikhail M. Krayushkin, Leonid V. Kovalenko, Adrian Esqueda, Srinivas Odde, Nouri Neamati
Publikováno v:
Molecules, Vol 15, Iss 6, Pp 3958-3992 (2010)
Raltegravir was the first HIV-1 integrase inhibitor that gained FDA approval for use in the treatment of HIV-1 infection. Because of the emergence of IN inhibitor-resistant viral strains, there is a need to identify innovative second-generation IN in
Externí odkaz:
https://doaj.org/article/23cb1d8e6e93474580135bba273d1aab
Autor:
Lauren A. Byers, Don L. Gibbons, Carl M. Gay, Jing Wang, John V. Heymach, You-Hong Fan, B. Leticia Rodriguez, David H. Peng, Robert J. Cardnell, Lixia Diao, Li Shen, Qi Wang, Carminia M. Della Corte, Kasey R. Cargill, C. Allison Stewart, Kavya Ramkumar
Supplementary Fig. S2: Spectra of EMT score and AXL expression across different tumor types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288e1609e52beaaa25a263cfb26a1533
https://doi.org/10.1158/1541-7786.22526639.v1
https://doi.org/10.1158/1541-7786.22526639.v1
Autor:
Lauren A. Byers, Don L. Gibbons, Carl M. Gay, Jing Wang, John V. Heymach, You-Hong Fan, B. Leticia Rodriguez, David H. Peng, Robert J. Cardnell, Lixia Diao, Li Shen, Qi Wang, Carminia M. Della Corte, Kasey R. Cargill, C. Allison Stewart, Kavya Ramkumar
Table S1. Mutations in key oncogenes in lung cancer cell lines tested.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27e9746a2cbf84f138754f24166ae49
https://doi.org/10.1158/1541-7786.22526621
https://doi.org/10.1158/1541-7786.22526621
Autor:
Lauren A. Byers, Don L. Gibbons, Carl M. Gay, Jing Wang, John V. Heymach, You-Hong Fan, B. Leticia Rodriguez, David H. Peng, Robert J. Cardnell, Lixia Diao, Li Shen, Qi Wang, Carminia M. Della Corte, Kasey R. Cargill, C. Allison Stewart, Kavya Ramkumar
AXL, a TAM (TYRO3, AXL, and MERTK) family receptor tyrosine kinase, is increasingly being recognized as a key determinant of resistance to targeted therapies, as well as chemotherapy and radiation in non–small cell lung cancer (NSCLC) and other can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c21d897465f7a08444ce7a8c783bcf
https://doi.org/10.1158/1541-7786.c.6545156.v1
https://doi.org/10.1158/1541-7786.c.6545156.v1
Autor:
Nouri Neamati, Mats Ljungman, Amy S. Lee, Kavya Ramkumar, Yuting Kuang, Ding Xue, Bikash Debnath, Suhui Yang, Soma Samanta
Supplementary materials include detailed chemistry, supplementary materials and methods, references, and supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a0db14c73bb81d9a8d5f6a064ca539
https://doi.org/10.1158/0008-5472.22428472
https://doi.org/10.1158/0008-5472.22428472