Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kavya Achanta"'
Autor:
Sara Bsharat, Emanuela Monni, Tania Singh, Jenny K. Johansson, Kavya Achanta, Ludivine Bertonnier-Brouty, Anja Schmidt-Christensen, Dan Holmberg, Zaal Kokaia, Rashmi B. Prasad, Isabella Artner
Publikováno v:
Development. 150
Hormone secretion from pancreatic islets is essential for glucose homeostasis, and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are crucial for establishing and maintaining adult endocrine cell functi
Publikováno v:
Aging (Albany NY)
Palikaras, K, Achanta, K, Choi, S, Akbari, M & Bohr, V A 2021, ' Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy ', Aging, vol. 13, no. 21, pp. 23876-23894 . https://doi.org/10.18632/aging.203683
Palikaras, K, Achanta, K, Choi, S, Akbari, M & Bohr, V A 2021, ' Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy ', Aging, vol. 13, no. 21, pp. 23876-23894 . https://doi.org/10.18632/aging.203683
Tauopathies are a group of progressive neurodegenerative disorders characterized by the presence of insoluble intracellular tau filaments in the brain. Evidence suggests that there is a tight connection between mitochondrial dysfunction and tauopathi
Autor:
Luis Rodrigo Cataldo, Tania Singh, Kavya Achanta, Sara Bsharat, Rashmi B. Prasad, Cheng Luan, Erik Renström, Lena Eliasson, Isabella Artner
Publikováno v:
Cataldo, L R, Singh, T, Achanta, K, Bsharat, S, Prasad, R B, Luan, C, Renström, E, Eliasson, L & Artner, I 2022, ' MAFA and MAFB regulate exocytosis-related genes in human β-cells ', Acta Physiologica, vol. 234, no. 2, e13761 . https://doi.org/10.1111/apha.13761
Reduced expression of exocytotic genes is associated with functional defects in insulin exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development. MAFA and MAFB transcription factors regulate β-cell physiology, and
Autor:
Ioanna Stavgiannoudaki, Johannes Jernqvist Gaare, Tanima SenGupta, Charalampos Tzoulis, Kavya Achanta, Konstantinos Palikaras, Vilhelm A. Bohr, Henok Kassahun, Mansour Akbari, Ying Esbensen, Georgios Konstantinidis, Nektarios Tavernarakis, Francisco Jose Naranjo Galindo, Hilde Nilsen
Publikováno v:
SenGupta, T, Palikaras, K, Esbensen, Y Q, Konstantinidis, G, Galindo, F J N, Achanta, K, Kassahun, H, Stavgiannoudaki, I, Bohr, V A, Akbari, M, Gaare, J, Tzoulis, C, Tavernarakis, N & Nilsen, H 2021, ' Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology ', Cell Reports, vol. 36, no. 10, 109668 . https://doi.org/10.1016/j.celrep.2021.109668
Cell Reports
Cell reports
Cell Reports
Cell reports
Summary Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99097903dc3cc021e38c55ee282c0dce
http://hdl.handle.net/10852/89478
http://hdl.handle.net/10852/89478
DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA repair pathways. An essential step in homology‐directed repair (HDR) of DNA breaks is the formation of RAD51 nucleofilaments mediated by PALB2–BRCA2; however, roles o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e456ed7c3250b0059f1989b51dfe545
https://europepmc.org/articles/PMC5341514/
https://europepmc.org/articles/PMC5341514/