Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kavitha Venkatesan"'
Autor:
Quan Zhong, Nicolas Simonis, Qian‐Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick, Marc Vidal
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-10 (2009)
Abstract Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively. Better understand
Externí odkaz:
https://doaj.org/article/be3eb24c4c74485895b266966800124a
Autor:
Han Yan, Kavitha Venkatesan, John E Beaver, Niels Klitgord, Muhammed A Yildirim, Tong Hao, David E Hill, Michael E Cusick, Norbert Perrimon, Frederick P Roth, Marc Vidal
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12139 (2010)
Predicting gene functions by integrating large-scale biological data remains a challenge for systems biology. Here we present a resource for Drosophila melanogaster gene function predictions. We trained function-specific classifiers to optimize the i
Externí odkaz:
https://doaj.org/article/39af1558626d4bb6a5d059593eae7bd8
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
PDF file - 1.4MB, Response to NVP-BGJ398; FGFR pathway modulation by NVP-BGJ398; NVP-BGJ398 - predictive features; FGFR2-c3 mRNA expression in cell lines and FGFR2 DNA copy number in tumors; FGF19 DNA copy number in CCLE cell lines and FGFR3 DNA copy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055d71ccbe50a65e308a5319a0af558a
https://doi.org/10.1158/2159-8290.22529469
https://doi.org/10.1158/2159-8290.22529469
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 99K, Kinase activity and selectivity for NVP-BGJ398; CCLE cell lines sensitive to NVP-BGJ398; GeneSet expression signatures; FGFR genetic alterations and concomitant mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394b8c19ed3865b26c4b23f7077d34aa
https://doi.org/10.1158/2159-8290.22529463.v1
https://doi.org/10.1158/2159-8290.22529463.v1
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 56K, High throughput pharmacological screen of BGJ398 in 517 cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2881a9c58817a03993b13427e5d262a1
https://doi.org/10.1158/2159-8290.22529466.v1
https://doi.org/10.1158/2159-8290.22529466.v1
Autor:
Michael D. Jones, Jonathan Bistline, Joshua M. Korn, Yiling Lu, Javad Golji, Michael Morrissey, Dale Porter, Robert Schlegel, Andrew A. Lane, Antoine de Weck, Manway Liu, James M. McFarland, Amanda L. Creech, Giordano Caponigro, Haoxin Li, Michael V. Rothberg, Christopher Lo, Franklin W. Huang, Juliann Shih, Ali Amin Mansour, Brian J. Haas, Judit Jané-Valbuena, Joseph Lehar, Nicolas Stransky, Rehan Akbani, Alexander Y. Andreev-Drakhlin, Gordon B. Mills, Kevin Hu, Gad Getz, Jaegil Kim, E. Robert McDonald, Mahdi Zamanighomi, Andrew D. Cherniack, Kevin Hadi, Francisca Vazquez, Frank Stegmeier, Mahmoud Ghandi, William C. Hahn, Ellen Gelfand, Michael S. Lawrence, Levi A. Garraway, Barbara A. Weir, Anupama Reddy, Todd R. Golub, Prafulla C. Gokhale, Audrey Kauffmann, Marcin Imielinski, François Aguet, Brenton R. Paolella, Allison Warren, Jacob D. Jaffe, Cory M. Johannessen, Jordi Barretina, Coyin Oh, Caitlin M. Dunning, William R. Sellers, Julian M. Hess, Dmitriy Sonkin, Hong L. Tiv, David M. Weinstock, Jesse S. Boehm, Aviad Tsherniak, Kavitha Venkatesan, Yanay Rosen, Jordan E. Taylor, Yosef E. Maruvka, Craig M. Bielski, Gregory V. Kryukov
Publikováno v:
Nature, vol 569, iss 7757
Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4416246e7ce1f8e7abd43f7a227b03
https://escholarship.org/uc/item/0kr533f8
https://escholarship.org/uc/item/0kr533f8
Autor:
Palermo Mark G, Timothy Michael Ramsey, Ping Zhu, Shumei Liu, Jay Larrow, Laura R. La Bonte, Rajesh Karki, Chen Christine Hiu-Tung, Kavitha Venkatesan, Jaison Jacob, Pascal D. Fortin, Francois Lenoir, Hui Gao, Guizhi Yang, Matthew J. Meyer, Ji-Hu Zhang, William R. Sellers, Michael Shultz, Denise Grunenfelder, Edmund Price, Jorge Garcia-Fortanet, Feng Fei, Zhouliang Chen, Gang Liu, Vesselina G. Cooke, Jing Yuan, Michelle Fodor, Ping Wang, Minying Pu, Nicholas Keen, Samuel B. Ho, Kathy Hsiao, Markus Warmuth, Travis Stams, Christopher Quinn, Mitsunori Kato, Subarna Shakya, Sarah Williams, Dyuti Majumdar, Peter Fekkes, Michael G. Acker, Cary Fridrich, Joanna Slisz, Huaixiang Hao, Matthew J. LaMarche, Ying-Nan P. Chen, Brandon Antonakos, Jason R. Dobson, Brant Firestone, Lawrence Blas Perez, Zhao B. Kang, Ho Man Chan, Zhan Deng
Publikováno v:
Nature. 535:148-152
SHP099, a selective inhibitor of signalling meditator SHP2 with drug-like properties, has an allosteric mechanism of action whereby it stabilizes SHP2 in an auto-inhibited conformation, and suppresses RAS–ERK signalling and proliferation in recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58ee0fa5f3f5109027ba2125d369122
https://doi.org/10.1038/nature18621
https://doi.org/10.1038/nature18621
Autor:
D. Randal Kipp, Craig Mickanin, Jeffery A. Porter, Albert Lai, Bing Zheng, Mark Stump, Yan Yan-Neale, John A. Tallarico, Young Shin Cho, Gregory R. Hoffman, Tobias Schmelzle, William R. Sellers, Samuel B. Ho, E. Robert McDonald, Kavitha Venkatesan, Yue Liu, Songping Zhao, Rosalie deBeaumont, Eric Billy, Ying Lin, Francesco Hofmann, Konstantinos J. Mavrakis, Vladimir Capka, Jianjun Yu, Antoine deWeck, Joshua T. McNamara, Emma Lees, Michael R. Schlabach, Hui Gao, Elizabeth R. Sprague, Nicholas Keen, Kristen Hurov, Kenneth Crawford, David A. Ruddy, David N. Ciccone, Guizhi Yang, Fallon Lin, Gregg McAllister, Justin Gu, Raymond Pagliarini, Alberto C. Vitari, Frank Stegmeier, Yingzi Yue, Hong Yin
Publikováno v:
Science. 351:1208-1213
Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities that can be exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90e55c3fe4c3ecfba28cea037cdc9ce
https://doi.org/10.1126/science.aad5944
https://doi.org/10.1126/science.aad5944
Autor:
Elena J. Edelman, Francesco Iorio, Frank Stegmeier, Gregory V. Kryukov, Mahmoud Ghandi, Michael R. Stratton, Robert Schlegel, Iulian Pruteanu-Malinici, Kavitha Venkatesan, Ultan McDermott, William R. Sellers, Michael P. Menden, Markus Riester, Cyril H. Benes, Michael B. Morrissey, Arnaud Amzallag, Dmitriy Sonkin, Audrey Kauffmann, Mathew J. Garnett, Sridhar Ramaswamy, Joseph Lehar, Giordano Caponigro, Daniel A. Haber, Levi A. Garraway, Manway Liu, Jordi Barretina, Julio Saez-Rodriguez, Nicolas Stransky
Publikováno v:
Nature. 528:84-87
Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6585a108b3d511e8380a865aa2c2d53
https://doi.org/10.1038/nature15736
https://doi.org/10.1038/nature15736
Autor:
Fabian Von Arx, Fergal Casey, Sonja Tobler, Robert Cozens, Ying Liang, En Li, E. Robert McDonald, John Monahan, Audrey Kauffmann, Chao Zhang, Hans Bitter, Daniel Wyss, Mallika Singh, Edward Lorenzana, Tara L. Naylor, Francesco Hofmann, Rebecca Leary, Peter Atadja, Alice Loo, Fiona Xu, Anupama Reddy, Hongbo Cai, Ernesta Dammassa, Margaret E. McLaughlin, Shannon Chuai, Yun Zhang, Fernando Salangsang, Susmita Chatterjee, Christian Schnell, Stephanie Barbe, Hui Gao, Michael Rugaard Jensen, Youzhen Wang, Nicholas Keen, William R. Sellers, Millicent Embry, O. Alejandro Balbin, John Green, Marion Wiesmann, Joseph Lehar, Francesca Santacroce, Guizhi Yang, Claudia Roelli, Scott D. Collins, Kavitha Venkatesan, Colleen Kowal, Hui Qin Wang, Montesa Patawaran, Angad P Singh, Jason Merkin, Juliet Williams, Walter Tinetto, Roberto Velazquez, Emma Lees, Stephane Ferretti, Ronald Meyer, Nicolas Ebel, Shawn Cogan, Joshua M. Korn, David A. Ruddy, Zongyao Wang, Yan Tang, Derek Y. Chiang, Nancy Pryer
Publikováno v:
Nature Medicine. 21:1318-1325
Profiling candidate therapeutics with limited cancer models during preclinical development hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous patient responses for patient-selection strategies. We established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801ad4a455ab1ef04a15fdf186eda57e
https://doi.org/10.1038/nm.3954
https://doi.org/10.1038/nm.3954