Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kavitha Sompalli"'
Autor:
James Chen, Lisa Johnson, Kelly McKenna, Timothy Choi, Jiaqi Duan, Dongdong Feng, Jonathan Tsai, Natalia Garcia-Martin, Kavitha Sompalli, Roy Maute, Paresh Vyas, Ravindra Majeti, Chris Takimoto, Jie Liu, Giridharan Ramsingh, Mark Chao, Jens-Peter Volkmer, Irving Weissman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a723632ee416401faf04f925a4c0ca4a
https://doi.org/10.1016/s2152-2650(22)01421-5
https://doi.org/10.1016/s2152-2650(22)01421-5
Autor:
James Chen, Lisa Johnson, Kelly McKenna, Timothy Choi, Jiaqi Duan, Dongdong Feng, Jonathan Tsai, Natalia Garcia-Martin, Kavitha Sompalli, Roy Maute, Paresh Vyas, Ravindra Majeti, Chris Takimoto, Jie Liu, Giridharan Ramsingh, Mark Chao, Jens-Peter Volkmer, Irving Weissman
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S154
Autor:
James Yuhtyng Chen, Lisa Johnson, Kelly Marie McKenna, Timothy S. Choi, Jiaqi Duan, Dongdong Feng, Jonathan M. Tsai, Natalia Garcia-Martin, Kavitha Sompalli, Roy Maute, Paresh Vyas, Ravindra Majeti, Chris H.M. Takimoto, Jie Liu, Giridharan Ramsingh, Mark Chao, Jens-Peter Volkmer, Irving L. Weissman
Publikováno v:
Journal of Clinical Oncology. 40:7054-7054
7054 Background: Magrolimab is a monoclonal antibody that blocks CD47, a “don’t eat me” signal expressed on cancer cells to escape immune surveillance and macrophage-mediated clearance. Prior preclinical studies have shown that CD47 is critical
Autor:
Jie Liu, Shirley Mihardja, Irving L. Weissman, Ravindra Majeti, Jens-Peter Volkmer, Balaji Agoram, Kavitha Sompalli, Sharline Chen, Seethu Xavy, Timothy S Choi, Dongdong Feng
Publikováno v:
JCI Insight
The CD47/signal regulatory protein α (Cd47/SIRPα)interaction provides a macrophage immune checkpoint pathway that plays a critical role in cancer immune evasion across multiple cancers. Here, we report the engineering of a humanized anti-SIRPα mon
Autor:
Jie Liu, Sharline Chen, Cynthia E. Dunbar, Irving L. Weissman, James Y. Chen, Balaji Agoram, Ravi Majeti, Kristopher D. Marjon, Chris H. Takimoto, Jiaqi Duan, Kavitha Sompalli, Timothy S Choi, Mark P. Chao, Mwe Mwe Chao, Jens-Peter Volkmer, Leslie S. Kean, Dongdong Feng, Ofelia Mata
Publikováno v:
Blood. 134:4428-4428
Background Hematopoietic stem cell (HSC) transplantation (HSCT) is a well-established procedure that, with or without gene therapy, is curative for numerous severe life-threatening diseases including genetic blood disorders and blood cancers. While a
Autor:
Chris H. Takimoto, Jiaqi Duan, Kavitha Sompalli, Mark P. Chao, Timothy S Choi, Lynette Brown, Kyle Elrod, Ravindra Majeti, Jie Liu, Jennifer J. Stewart, Jens-Peter Volkmer, Mckenna Kelly Marie, James Y. Chen, Stanley L. Schrier, Paresh Vyas, Irving L. Weissman
Publikováno v:
Blood. 132:2327-2327
CD47 is an anti-phagocytic (i.e. "don't eat me") signal and macrophage checkpoint that cancer cells utilize to evade innate immunity and establish disease. 5F9 is a humanized IgG4 monoclonal antibody (mAb) that binds to human CD47 and blocks its inte