Evaluation of biomimetic hyaluronic-based hydrogels with enhanced endogenous cell recruitment and cartilage matrix formation

Autor: Avner Yayon, Sibylle Grad, Nicole Kops, Andrea Lolli, M.L. Vainieri, Domenico D'Atri, G.J.V.M. van Osch, Kavitha Sivasubramaniyan, Mauro Alini, David Eglin

Publikováno v: Acta Biomaterialia, 101, 293-303. Elsevier
Acta Biomater

Biomaterials play a pivotal role in cell-free cartilage repair approaches, where cells must migrate through the scaffold, fill the defect, and then proliferate and differentiate facilitating tissue remodeling. Here we used multiple assays to test the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0394fc67e79f99f9334fcb0da1d02d57
https://pure.eur.nl/en/publications/0ede2bd1-7ed8-4154-92bb-64f7efe67e84

Cell-surface markers identify tissue resident multipotential stem/stromal cell subsets in synovial intimal and sub-intimal compartments with distinct chondrogenic properties

Autor: S. Chubinskaya, Eric Farrell, Kavitha Sivasubramaniyan, Arnavaz A. Hakimiyan, M. Sande, Jan A N Verhaar, G.J.V.M. van Osch, Martin J. Hoogduijn, H.-J. Bühring, Wendy Koevoet

Publikováno v: Osteoarthritis and Cartilage, 27(12), 1831-1840. W.B. Saunders

Summary Objective Synovium contains multipotent progenitor/stromal cells (MPCs) with potential to participate in cartilage repair. Understanding the identity of these MPCs will allow their therapeutic potential to be fully exploited. Hence this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f9b44abceb02ae90698e1770296729
https://doi.org/10.1016/j.joca.2019.08.006

Bone Marrow–Harvesting Technique Influences Functional Heterogeneity of Mesenchymal Stem/Stromal Cells and Cartilage Regeneration

Autor: Wendy Koevoet, Elena Jones, Peter de Zwart, Kavitha Sivasubramaniyan, Heather E. Owston, Gerjo J.V.M. van Osch, Abhishek Harichandan, Diego L Santos, Hans-Jörg Bühring, Pieter K. Bos, Dragos C Ilas

Publikováno v: The American Journal of Sports Medicine
American Journal of Sports Medicine, 46(14), 3521-3531. SAGE Publishing
The American Journal of Sports Medicine, 46(14), 3521-3531. SAGE Publications Inc.

Background: Connective tissue progenitors (CTPs) from native bone marrow (BM) or their culture-expanded progeny, often referred to as mesenchymal stem/stromal cells, represents a promising strategy for treatment of cartilage injuries. But the cartila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d5b4e986440646608e021722434d09
http://europepmc.org/articles/PMC6282158

Prospective Isolation of Mesenchymal Stem Cells from Human Bone Marrow Using Novel Antibodies Directed Against Sushi Domain Containing 2

Autor: Hubert Kalbacher, Claudia Lengerke, Malgorzata Sobiesiak, Kavitha Sivasubramaniyan, Abhishek Harichandan, Susanne Schumann, Andreas Maurer, Hans-Jörg Bühring

Publikováno v: Stem Cells and Development. 22:1944-1954

Several strategies have been developed to facilitate the prospective isolation of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) based on the selective expression or absence of surface markers. Recently, we described the monoclonal anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6532a53d61f90c2f0d769dbbb24fef
https://doi.org/10.1089/scd.2012.0584

Isolation of phenotypically and functionally distinct endogeneous human bone marrow-derived mesenchymal stem/stromal cell subsets

Autor: G.J.V.M. van Osch, Kavitha Sivasubramaniyan, H.-J. Buehring, Abhishek Harichandan, P. Boss

Publikováno v: Osteoarthritis and Cartilage. 24

Articular cartilage is difficult to heal once injury or disease occurs. Human bone marrow-derived mesenchymal stem/stromal cells (MSCs) are being increasingly explored for therapeutic use in cartilage regeneration. However, MSCs are commonly defined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ff6faf7cf0d4b1ab8528ca3ad4fa22