Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kavitha Sarma"'
Autor:
Grant P. Grothusen, Renxu Chang, Zhendong Cao, Nan Zhou, Monika Mittal, Arindam Datta, Phillip Wulfridge, Thomas Beer, Baiyun Wang, Ning Zheng, Hsin-Yao Tang, Kavitha Sarma, Roger A. Greenberg, Junwei Shi, Luca Busino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological function of DCAF15 remains unknown
Externí odkaz:
https://doaj.org/article/5e99b4c061aa4b64a6e849f6c37a88ab
Autor:
Qingqing Yan, Phillip Wulfridge, John Doherty, Jose L. Fernandez-Luna, Pedro J. Real, Hsin-Yao Tang, Kavitha Sarma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, includin
Externí odkaz:
https://doaj.org/article/cb8dad63113f446f9ed14a035477d404
Autor:
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway
Externí odkaz:
https://doaj.org/article/30c7f569e8f14f29b50078b914b06fde
Autor:
Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment
Externí odkaz:
https://doaj.org/article/d53e091c9d8f44fbb7268b39edf59f2b
Autor:
Phillip Wulfridge, Kavitha Sarma
Publikováno v:
eLife, Vol 10 (2021)
R-loops are three-stranded nucleic acid structures with essential roles in many nuclear processes. However, their unchecked accumulation is associated with genome instability and is observed in neurodevelopmental diseases and cancers. Genome-wide pro
Externí odkaz:
https://doaj.org/article/0012d3d891c74939b88c86fe2f7bec2e
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1369-1380.e5 (2019)
Summary: R-loops are three-stranded DNA:RNA hybrids that are implicated in many nuclear processes. While R-loops may have physiological roles, the formation of stable, aberrant R-loops has been observed in neurological disorders and cancers. Current
Externí odkaz:
https://doaj.org/article/adce525a7b024376a6c2be0f48970cef
Publikováno v:
Nucleic Acids Research. 50:9162-9174
ATRX is a chromatin remodeler, which is mutated in ATRX syndrome, a neurodevelopmental disorder. ATRX mutations that alter histone binding or chromatin remodeling activities cluster in the PHD finger or the helicase domain respectively. Using enginee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1729bfaf661fd863b3bb2df63f026559
https://doi.org/10.1093/nar/gkac683
https://doi.org/10.1093/nar/gkac683
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2528
R-loops are three-stranded, DNA:RNA hybrid-containing structures that form naturally throughout the genome as a consequence of transcription. Accurately determining the genomic locations and strand of origin of R-loops is critical to understanding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27a7d9233263fe851ca8a71d4a9be47a
https://pubmed.ncbi.nlm.nih.gov/35704205
https://pubmed.ncbi.nlm.nih.gov/35704205
Autor:
Cuijuan Han, Alireza Khodadadi-Jamayran, Adam H. Lorch, Qi Jin, Valentina Serafin, Ping Zhu, Yuliya Politanska, Limin Sun, Blanca T. Gutierrez-Diaz, Marina V. Pryzhkova, Hiam Abdala-Valencia, Elizabeth Thomas Bartom, Barbara Buldini, Giuseppe Basso, Sadanandan E. Velu, Kavitha Sarma, Basil B. Mattamana, Byoung-Kyu Cho, Rebecca C. Obeng, Young Ah Goo, Philip W. Jordan, Aristotelis Tsirigos, Yalu Zhou, Panagiotis Ntziachristos
Publikováno v:
Science Advances
SCIENCE ADVANCES
SCIENCE ADVANCES
The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4b85e27d019d55f418b8ed24476b33
https://doi.org/10.1126/sciadv.abj8357
https://doi.org/10.1126/sciadv.abj8357
Publikováno v:
R-Loops ISBN: 9781071624760
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76dd6e81f82541f2050f0b31e698a499
https://doi.org/10.1007/978-1-0716-2477-7_25
https://doi.org/10.1007/978-1-0716-2477-7_25
