Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kavitha Narayan"'
Autor:
Nitya Jain, Wu Zhihao, Amy Palin, Heather J. Melichar, Bing Miu, Katelyn Sylvia, Kavitha Narayan, Jan Kisielow, Paul E. Love, Michihiro Kobayashi, Momoko Yoshimoto, Michela Frascoli, Joonsoo Kang, Thomas Serwold, Nicholas A. Spidale
Summary Lineage-committed αβ and γδ T cells are thought to originate from common intrathymic multipotent progenitors following instructive T cell receptor (TCR) signals. A subset of lymph node and mucosal Vγ2+ γδ T cells is programmed intrathy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe5e8616f13b830e3ccc33b8f81863a
https://europepmc.org/articles/PMC6249057/
https://europepmc.org/articles/PMC6249057/
Autor:
Serena T. Pham, Katherine A. Fitzgerald, Jennifer P. Wang, Kavitha Narayan, Stephen N. Waggoner, Gabriel L. Hendricks, Joseph E. Conlon, Joonso Kang, Lisa Waggoner
Publikováno v:
Journal of Virology. 88:10748-10757
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are essential intracellular detectors of viral RNA. They contribute to the type I interferon (IFN) response that is crucial for host defense against viral in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467c18b903667635a138aafbf98ad9da
https://doi.org/10.1128/jvi.02593-13
https://doi.org/10.1128/jvi.02593-13
Autor:
John D. Gagnon, Caitlin N. Russell, Hans Christian Reinecker, Joo Hye Song, Daniel B. Graham, Vlado Dančík, Mahmud M. Hussain, Alykhan F. Shamji, Ramnik J. Xavier, Nathanael S. Gray, Hwan Geun Choi, José Carlos Rodríguez Pérez, Stuart L. Schreiber, Bernard Khor, Thomas B. Sundberg, Kavitha Narayan, Daniel J. O’Connell
Publikováno v:
Proceedings of the National Academy of Sciences. 111:12468-12473
Genetic alterations that reduce the function of the immunoregulatory cytokine IL-10 contribute to colitis in mouse and man. Myeloid cells such as macrophages (MΦs) and dendritic cells (DCs) play an essential role in determining the relative abundanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07c5e30953e081506277431bb862f87
https://doi.org/10.1073/pnas.1412308111
https://doi.org/10.1073/pnas.1412308111
Autor:
Jean Xu, Timothy J. Kieffer, John J. O'Neil, Jennifer E. Bruin, Kavitha Narayan, Jessica K. Fox, Alireza Rezania
Publikováno v:
Stem Cells. 31:2432-2442
Human embryonic stem cells (hESCs) are considered a potential alternative to cadaveric islets as a source of transplantable cells for treating patients with diabetes. We previously described a differentiation protocol to generate pancreatic progenito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6ca8e940954fba7c10d0ecafe6fefa
https://doi.org/10.1002/stem.1489
https://doi.org/10.1002/stem.1489
Autor:
John J. O'Neil, Kavitha Narayan, Jean Xu, Timothy J. Kieffer, Jessica K. Fox, Alireza Rezania, Jennifer E. Bruin
Publikováno v:
Diabetologia. 56:1987-1998
Islet transplantation is a promising cell therapy for patients with diabetes, but it is currently limited by the reliance upon cadaveric donor tissue. We previously demonstrated that human embryonic stem cell (hESC)-derived pancreatic progenitor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933f98bd8751768a3eef680d968c8d65
https://doi.org/10.1007/s00125-013-2955-4
https://doi.org/10.1007/s00125-013-2955-4
A Network of High-Mobility Group Box Transcription Factors Programs Innate Interleukin-17 Production
Autor:
Véronique Lefebvre, Joonsoo Kang, Nidhi Malhotra, Leslie J. Berg, Catherine C. Yin, Ok Hyun Cho, Katelyn Sylvia, John E. Harris, Kavitha Narayan, Heather J. Melichar, M. Rashighi
Publikováno v:
Immunity. 38:681-693
Summary How innate lymphoid cells (ILCs) in the thymus and gut become specialized effectors is unclear. The prototypic innate-like γδ T cells (Tγδ17) are a major source of interleukin-17 (IL-17). We demonstrate that Tγδ17 cells are programmed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec540749848bd105670c454e93893b0d
https://doi.org/10.1016/j.immuni.2013.01.010
https://doi.org/10.1016/j.immuni.2013.01.010
Autor:
Catherine C. Yin, Ok Hyun Cho, Katelyn Sylvia, Amanda Prince, Leslie J. Berg, Joonsoo Kang, Kavitha Narayan, John W. Evans
Publikováno v:
The Journal of Immunology. 190:2659-2669
The Tec family tyrosine kinase, Itk, regulates signaling downstream of the TCR. The absence of Itk in CD4+ T cells results in impaired Th2 responses along with defects in maturation, cytokine production, and survival of iNKT cells. Paradoxically, Itk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d72728a21868a12c13b13d1cddbde4
https://doi.org/10.4049/jimmunol.1202531
https://doi.org/10.4049/jimmunol.1202531
Autor:
Jean Xu, Timothy J. Kieffer, Ali Asadi, Ziliang Ao, Garth L. Warnock, Alireza Rezania, Jennifer E. Bruin, Francis Karanu, Rebecca Gauvin, Kavitha Narayan, Michael J. Riedel, John J. O'Neil, Majid Mojibian
Publikováno v:
Diabetes
Diabetes is a chronic debilitating disease that results from insufficient production of insulin from pancreatic β-cells. Islet cell replacement can effectively treat diabetes but is currently severely limited by the reliance upon cadaveric donor tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c6742e4fcef41a3ce09cb92284ee44
https://doi.org/10.2337/db11-1711
https://doi.org/10.2337/db11-1711
Autor:
Yan Jin, Kavitha Narayan, David L. Wiest, Mingcan Xia, Joonsoo Kang, Yanming Wang, Christina M. Saylor, Na Xiong
Publikováno v:
The Journal of Immunology. 185:7156-7160
Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36135576d308c0a9f78b64e328ec2b73
https://doi.org/10.4049/jimmunol.1002781
https://doi.org/10.4049/jimmunol.1002781
Autor:
Joonsoo Kang, Kavitha Narayan
Publikováno v:
Seminars in Immunology. 22:222-227
The mechanism of T cell precursor commitment to the γδ or αβ T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7d6b61a023a3ea7594d97e9369968a
https://doi.org/10.1016/j.smim.2010.04.003
https://doi.org/10.1016/j.smim.2010.04.003