De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling.

Autor: Bhat S; Department of Biomedical Engineering, Duke University., Palepu K; Department of Biomedical Engineering, Duke University., Hong L; Department of Biomedical Engineering, Duke University., Mao J; Department of Cell Biology, Duke University., Ye T; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA., Iyer R; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA., Zhao L; Department of Biomedical Engineering, Duke University., Chen T; Department of Biomedical Engineering, Duke University., Vincoff S; Department of Biomedical Engineering, Duke University., Watson R; Department of Biomedical Engineering, Duke University., Wang T; Department of Biomedical Engineering, Duke University., Srijay D; Department of Biomedical Engineering, Duke University., Kavirayuni VS; Department of Biomedical Engineering, Duke University., Kholina K; Department of Biomedical Engineering, Duke University., Goel S; Department of Biomedical Engineering, Duke University., Vure P; Department of Biomedical Engineering, Duke University., Desphande AJ; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA., Soderling SH; Department of Cell Biology, Duke University., DeLisa MP; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY, USA., Chatterjee P; Department of Biomedical Engineering, Duke University.; Department of Computer Science, Duke University.; Department of Biostatistics and Bioinformatics, Duke University.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.

Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression.

Autor: Pierson Smela MD; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States., Kramme CC; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States., Fortuna PRJ; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States., Adams JL; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States., Su R; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States., Dong E; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States., Kobayashi M; Massachusetts General Hospital Center for Cancer Research, Harvard Medical School, Charlestown, United States., Brixi G; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States.; Department of Biomedical Engineering, Duke University, Durham, United States.; Department of Computer Science, Duke University, Durham, United States., Kavirayuni VS; Department of Biomedical Engineering, Duke University, Durham, United States.; Department of Computer Science, Duke University, Durham, United States., Tysinger E; Department of Biomedical Engineering, Duke University, Durham, United States.; Department of Computer Science, Duke University, Durham, United States., Kohman RE; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States., Shioda T; Massachusetts General Hospital Center for Cancer Research, Harvard Medical School, Charlestown, United States., Chatterjee P; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States.; Department of Biomedical Engineering, Duke University, Durham, United States.; Department of Computer Science, Duke University, Durham, United States., Church GM; Wyss Institute, Harvard University, Boston, United States.; Department of Genetics, Harvard Medical School, Boston, United States.

Publikováno v: ELife [Elife] 2023 Feb 21; Vol. 12. Date of Electronic Publication: 2023 Feb 21.