Use of a Cyclic α-Alkylidene-β-Diketone as a Cleavable Linker Strategy for Antibody-Drug Conjugates.

Autor: Tong JTW; School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand., Sarwar M; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand.; Department of Obstetrics and Gynaecology, University of Otago, Christchurch, Christchurch 8011, New Zealand., Ahangarpour M; School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand., Hume PA; Department of Obstetrics and Gynaecology, University of Otago, Christchurch, Christchurch 8011, New Zealand.; School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.; MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington 6012, New Zealand., Williams GM; School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand., Brimble MA; School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand., Kavianinia I; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand.; School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Aug 28; Vol. 146 (34), pp. 23717-23728. Date of Electronic Publication: 2024 Aug 15.

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On-Resin Conjugation of the Ruthenium Anticancer Agent Plecstatin-1 to Peptide Vectors.

Autor: Kumar S; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Riisom M; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Jamieson SMF; Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Kavianinia I; School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Harris PWR; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Metzler-Nolte N; Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum 44801, Germany., Brimble MA; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.; School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Hartinger CG; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Publikováno v: Inorganic chemistry [Inorg Chem] 2023 Sep 04; Vol. 62 (35), pp. 14310-14317. Date of Electronic Publication: 2023 Aug 23.

The Anti-Tubercular Aminolipopeptide Trichoderin A Displays Selective Toxicity against Human Pancreatic Ductal Adenocarcinoma Cells Cultured under Glucose Starvation.

Autor: Kasim JK; School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand., Hong J; School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Surgical and Translational Research Centre, The University of Auckland, 22-30 Park Avenue, Auckland 1023, New Zealand.; Department of Surgery, The University of Auckland, 22-30 Park Avenue, Auckland 1023, New Zealand., Hickey AJR; School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand., Phillips ARJ; School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Surgical and Translational Research Centre, The University of Auckland, 22-30 Park Avenue, Auckland 1023, New Zealand.; Department of Surgery, The University of Auckland, 22-30 Park Avenue, Auckland 1023, New Zealand., Windsor JA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Surgical and Translational Research Centre, The University of Auckland, 22-30 Park Avenue, Auckland 1023, New Zealand.; Department of Surgery, The University of Auckland, 22-30 Park Avenue, Auckland 1023, New Zealand., Harris PWR; School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand., Brimble MA; School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand., Kavianinia I; School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.; School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.

Publikováno v: Pharmaceutics [Pharmaceutics] 2023 Jan 14; Vol. 15 (1). Date of Electronic Publication: 2023 Jan 14.

N -Vinyl Acrylamides: Versatile Heterobifunctional Electrophiles for Thiol-Thiol Bioconjugations.

Autor: Ahangarpour M; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand., Kavianinia I; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand., Hume PA; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand., Harris PWR; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand., Brimble MA; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Aug 03; Vol. 144 (30), pp. 13652-13662. Date of Electronic Publication: 2022 Jul 20.