Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kaveri Rangachari"'
Autor:
Robin J. Leatherbarrow, Edward W. Tate, Kaveri Rangachari, Anthony A. Holder, Z. Yu, Anthony J. Wilkinson, William P. Heal, James A. Brannigan
Publikováno v:
MedChemComm. 6:1767-1772
N-Myristoyltransferase (NMT) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. Scaffold simplification from previously reported inh
Autor:
Anthony A. Holder, Kaveri Rangachari, Antonio Donaire, Miguel A. De la Rosa, Andres Ramos, Adrián Velázquez-Campoy, Berry Birdsall, Isabel Cruz-Gallardo, Irene Díaz-Moreno, Rachel D. Curd, Antonio Díaz-Quintana
Publikováno v:
Journal of Biological Chemistry. 288:20896-20907
The discovery of effective new antimalarial agents is urgently needed. One of the most frequently studied molecules anchored to the parasite surface is the merozoite surface protein-1 (MSP1). At red blood cell invasion MSP1 is proteolytically process
Publikováno v:
Journal of Biological Chemistry. 281:8371-8378
Protein products of the suf operon are involved in iron-sulfur metabolism. SufC is an ATPase that can interact with SufB in the absence of nucleotide. We have studied the transient kinetics of the SufC ATPase mechanism using the fluorescent ATP analo
Publikováno v:
Molecular and Biochemical Parasitology. 130:155-158
Autor:
D. H. Williamson, Daphne J. Moore, P. W. Moore, Malcolm Strath, Peter R. Preiser, Kaveri Rangachari, Roy A, Robert J.M. Wilson, Paul W. Denny, Roberts K, Whyte A
Publikováno v:
Journal of Molecular Biology. 261:155-172
Malaria parasites, and other parasitic protists of the Phylum Apicomplexa, carry a plastid-like genome with greatly reduced sequence complexity. This 35 kb DNA circle resembles the plastid DNA of non-photosynthetic plants, encoding almost exclusively
Autor:
Malcolm Strath, Robert J.M. Wilson, Malcolm J. Gardner, Nick Goldman, P. W. Moore, Donald H. Williamson, Kaveri Rangachari, Phillip Barnett, Andrea Whyte
Publikováno v:
Molecular and biochemical parasitology, 66(2), 221-231. Elsevier
Malaria and other Apicomplexan parasites harbour two extrachromosomal DNAs. One is mitochondrial and the other is a 35-kb circle with some plastid-like features but whose provenance and function is unknown. In addition to genes for rRNAs, tRNAs and r
Autor:
John F. Eccleston, Barbara Clough, Arsen Petrovic, Colin T. Davis, Kaveri Rangachari, Robert J.M. Wilson
Publikováno v:
Protein science : a publication of the Protein Society. 17(7)
Bacteria, as well as the plastid organelles of algae and higher plants, utilize proteins of the suf operon. These are involved in Fe-S cluster assembly, particularly under conditions of iron limitation or oxidative stress. Genetic experiments in some
Publikováno v:
The Journal of biological chemistry. 281(13)
Protein products of the suf operon are involved in iron-sulfur metabolism. SufC is an ATPase that can interact with SufB in the absence of nucleotide. We have studied the transient kinetics of the SufC ATPase mechanism using the fluorescent ATP analo
Autor:
John F. Eccleston, Lisa Rickman, José W. Saldanha, Roger S. Buxton, Robert J.M. Wilson, Kaveri Rangachari
Malaria and related parasites retain a vestigial, but biosynthetically active, plastid organelle acquired far back in evolution from a red algal cell. The organelle appears to be essential for parasite transmission from cell to cell and carries the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7783805cf35a87f34e679d0654f0d03
https://europepmc.org/articles/PMC1693094/
https://europepmc.org/articles/PMC1693094/
Autor:
Robert J.M. Wilson, Daphne J. Moore, Kaveri Rangachari, Malcolm J. Gardner, Peter R. Preiser, Donald H. Williamson
Publikováno v:
Moleculargeneral genetics : MGG. 243(2)
In common with other Apicomplexan parasites, Plasmodium falciparum carries two extrachromosomal DNAs, one of which, the 6 kb element, is undoubtedly mitochondrial. The second, generally referred to as the 35 kb circle, is of unknown provenance, but t