Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kaveh Matinkhoo"'
Autor:
Sheetal A. Raithatha, Jillian M. Hagel, Kaveh Matinkhoo, Lisa Yu, David Press, Sarah G. Cook, Govinda Sharma, Dhananjaya D., Glynnis Jensen, Jessica B. Lee, Charlie Cai, Jonathan Gallant, Jaideep S. Bains, Joseph E. Tucker, Peter J. Facchini
The psychedelic compound psilocybin has shown therapeutic benefit in the treatment of numerous psychiatric diseases. A recent randomized clinical trial conducted at Johns Hopkins Bayview Medical Center demonstrated the efficacy of psilocybin-assisted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f670e03ad5c8521c0f565abb4bfbbfa9
https://doi.org/10.1101/2023.05.16.540994
https://doi.org/10.1101/2023.05.16.540994
Autor:
Alla Pryyma, David M. Perrin, Yong Jia Bu, Helen Merkens, Francois Benard, Zhengxing Zhang, Kaveh Matinkhoo
Publikováno v:
RSC Chemical Biology
Targeted cancer therapy represents a paradigm-shifting approach that aims to deliver a toxic payload selectively to target-expressing cells thereby sparing normal tissues the off-target effects associated with traditional chemotherapeutics. Since mos
Autor:
Torsten Hechler, Andreas Pahl, Alexandra Braun, Kaveh Matinkhoo, Brandon Kato, Christoph Müller, Francesca Gallo, Antonio A. W. L. Wong, Charlie Wei, Chido M. Hambira, David M. Perrin
Publikováno v:
Chemistry – A European Journal. 27:10282-10292
Alpha-amanitin, an extremely toxic bicyclic octapeptide extracted from the death-cap mushroom, Amanita phalloides, is a highly selective allosteric inhibitor of RNA polymerase II. Following on growing interest in using this toxin as a payload in anti
Publikováno v:
The Journal of Organic Chemistry. 86:5362-5370
Here we report a scalable synthesis of the key amino acid residue, (2S,3R,4R)-4,5-dihydroxyisoleucine (DHIle) in α-amanitin, that in turn enables the scalable synthesis of an equipotent analogue, Asn(N-ethylazide)-S,6'-dideoxy-α-amanitin, suitable
Publikováno v:
Chemical communications (Cambridge, England). 57(75)
Amanitin is used extensively as a research tool to inhibit RNA Pol II thereby implicating its role in mRNA transcription. Recently, amanitin has gained traction as a toxic payload for targeted therapy. Here we report the first-ever photocaged amaniti
Publikováno v:
Chemical Science
Appreciating the need to access synthetic analogs of amanitin, here we report the synthesis of 5′-hydroxy-6′-deoxy-amanitin, a novel, rationally-designed bioactive analog and constitutional isomer of α-amanitin, that is anticipated to be used as
Publikováno v:
The Journal of organic chemistry. 86(7)
Here we report a scalable synthesis of the key amino acid residue, (2
Publikováno v:
Journal of the American Chemical Society. 140:6513-6517
α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells. Recent interest in α-amanitin arises from its prom
Autor:
Torsten Hechler, Charlie Wei, Andreas Pahl, Francesca Gallo, Antonio A. W. L. Wong, Alexandra Braun, Chido M. Hambira, Christoph Müller, Brandon Kato, Kaveh Matinkhoo, David M. Perrin
Publikováno v:
Chemistry – A European Journal. 27:10212-10212
Autor:
Liang Zhao, Anastak Loonchanta, David M. Perrin, Alla Pryyma, Jonathan P. May, Antoine Blanc, David Dietrich, Kaveh Matinkhoo
Publikováno v:
ChemBioChem. 16:1420-1425
Alpha-amanitin is an exceedingly toxic, naturally occurring, bicyclic octapeptide that inhibits RNA polymerase and results in cellular and organismal death. Here we report the straightforward synthesis of an amanitin analogue that exhibited near-nati