Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Autor: Lucile Grimbert, Maria-Nieves Sanz, Mélanie Gressette, Catherine Rucker-Martin, Marta Novotova, Audrey Solgadi, Ahmed Karoui, Susana Gomez, Kaveen Bedouet, Eric Jacquet, Christophe Lemaire, Vladimir Veksler, Mathias Mericskay, Renée Ventura-Clapier, Jérôme Piquereau, Anne Garnier

Publikováno v: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-24 (2021)

Highlights AMPK is a metabolic sensor of cellular energy which regulates energy homeostasis. We generated a cardiac-specific inducible deletion of Ampkα2 and demonstrated that this deletion induces mild cardiac dysfunction in male only. Cardiac dysf

Externí odkaz: https://doaj.org/article/81438108d8ef4b59a82a8ad86e49fea4

Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Autor: Mélanie Gressette, Eric Jacquet, Marta Novotova, Vladimir Veksler, Mathias Mericskay, Kaveen Bedouet, Audrey Solgadi, Ahmed Karoui, Maria-Nieves Sanz, Anne Garnier, Renée Ventura-Clapier, Lucile Grimbert, Catherine Rucker-Martin, Christophe Lemaire, Susana Gomez, Jérôme Piquereau

Publikováno v: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-24 (2021)
Biology of Sex Differences
Biology of Sex Differences, BioMed Central, 2021, 12 (1), ⟨10.1186/s13293-021-00394-z⟩
Biology of Sex Differences, 2021, 12 (1), ⟨10.1186/s13293-021-00394-z⟩

Background The AMP-activated protein kinase (AMPK) is a major regulator of cellular energetics which plays key role in acute metabolic response and in long-term adaptation to stress. Recent works have also suggested non-metabolic effects. Methods To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97537c64633a4b195360395a4118af9
https://doaj.org/article/81438108d8ef4b59a82a8ad86e49fea4

Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload

Autor: Catherine Rucker-Martin, Justin F. X. Ainscough, Baptiste Rode, Philippe Mateo, Florence Lefebvre, Jessica Sabourin, Hollie L. Appleby, Richard Foster, Kaveen Bedouet, Susana Gomez, Jian Shi, Alexander-Francisco Bruns, Fabrice Antigny, Jean-Pierre Benitah, Marc A. Bailey, Rajendra Gosain, Heba Shawer, Fiona Bartoli, Pascale Gerbaud, Richard S. Young, Marjolaine Debant, Jeffrey Plante, A.M. Gomez, Mark T. Kearney, Katherine Norman, David J. Beech

Publikováno v: Circulation

Supplemental Digital Content is available in the text.
Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe58c0b96e2fb37da8bd7fd0017e0c7a
http://europepmc.org/articles/PMC6970549