Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kavash, Robert"'
Publikováno v:
In Journal of Molecular Graphics and Modelling 2005 23(5):409-418
Autor:
Chaozhong Cai, Alexey B. Dyatkin, Paul R. Wade, Kavash Robert W, Sui-Po Zhang, Henry J. Breslin, Craig J. Diamond, Wei He, Tamara A. Miskowski, Pamela J. Hornby
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4869-4872
A small set of acyclic analogs 5 were prepared to explore their structure-activity relationships (SARs) relative to heterocyclic core, opioid receptor (OR) agonists 4. Compound 5l was found to have very favorable OR binding affinities at the δ and
Publikováno v:
Journal of Molecular Graphics and Modelling. 23:409-418
A homology model of the active site region of tripeptidyl peptidase II (TPP II) was constructed based on the crystal structures of four subtilisin-like templates. The resulting model was subsequently validated by judging expectations of the model ver
Autor:
Breslin, Henry J., Diamond, Craig J., Kavash, Robert W., Cai, Chaozhong, Dyatkin, Alexey B., Miskowski, Tamara A., Zhang, Sui-Po, Wade, Paul R., Hornby, Pamela J., He, Wei
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 July 2012 22(14):4869-4872
Autor:
Peter Walter Maria Roevens, Hans De Winter, Kavash Robert W, Michael Joseph Kukla, Maria V. F. Somers, Henry J. Breslin, Tamara A. Miskowski
Publikováno v:
ChemInform. 35
We have systematically explored the structure–activity relationship (SAR) for a series of compounds 2 as inhibitors of tripeptidyl-peptidase II (TPP II), a serine protease responsible for the degradation of cholecystokinin-8 (CCK-8). This SAR evalu
Autor:
Maria V. F. Somers, Tamara A. Miskowski, Michael Joseph Kukla, Peter Walter Maria Roevens, Hans De Winter, Kavash Robert W, Henry J. Breslin
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(24)
We have systematically explored the structure–activity relationship (SAR) for a series of compounds 2 as inhibitors of tripeptidyl-peptidase II (TPP II), a serine protease responsible for the degradation of cholecystokinin-8 (CCK-8). This SAR evalu
Autor:
Lewi, Paul, de Jonge, Frederik, Daeyaert, Frits, Koymans, Luc, Vinkers, Maarten, Heeres, Jan, Janssen, Paul A.J., Arnold, Eddy, Das, Kalyan, Clark, Art D., Stephen, H. Hughes, Boyer, Paul L., de Béthune, Marie-Pierre, Pauwels, Rudi, Andries, Koen, Kukla, Mike, Ludovici, Donald, de Corte, Bart, Kavash, Robert, Ho, Chih
Publikováno v:
Journal of computer-aided molecular design
Akademický článek
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Akademický článek
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Autor:
Breslin, Henry J., Miskowski, Tamara A., Kukla, Michael J., De Winter, Hans L., Somers, Maria V.F., Roevens, Peter W.M., Kavash, Robert W.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 December 2003 13(24):4467-4471