Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kavankumar Patel"'
Autor:
Hyun Lee, Tian Zhu, Kavankumar Patel, Yan-Yan Zhang, Lena Truong, Kirk E Hevener, Joseph L Gatuz, Gitanjali Subramanya, Hyun-Young Jeong, Susan L Uprichard, Michael E Johnson
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75144 (2013)
Development of drug-resistant mutations has been a major problem with all currently developed Hepatitis C Virus (HCV) NS3/4A inhibitors, including the two FDA approved drugs, significantly reducing the efficacy of these inhibitors. The high incidence
Externí odkaz:
https://doaj.org/article/865643715fb8455293491e77012d45c1
Autor:
Kavankumar Patel, Leslie W.-M. Fung, Christopher R. Jones, Tian Zhu, Michael E. Johnson, Nina M. Wolf, Hyun Lee, Hao Lei
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:596-605
The de novo purine biosynthesis pathway is an attractive target for antibacterial drug design, and PurE from this pathway has been identified to be crucial for Bacillus anthracis survival in serum. In this study we adopted a fragment-based hit discov
Autor:
Michael Z. Szypulinski, Michael E. Johnson, Hyun Lee, Kavankumar Patel, Joseph L. Gatuz, Isabel Ojeda, Hao Lei, Shuyi Cao, Bernard D. Santarsiero, Amy J. Rice, Arun K. Ghosh
Publikováno v:
ACS Chemical Biology
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) papain-like protease (PLpro) blocking loop 2 (BL2) structure differs significantly from that of SARS-CoV PLpro, where it has been proven to play a crucial role in SARS-CoV PLpro inhibitor bi
Autor:
Joseph L. Gatuz, Michael E. Johnson, Shuyi Cao, Arun K. Ghosh, Kavankumar Patel, Kirk E. Hevener, Lena Truong, Hyun Lee
Publikováno v:
ChemMedChem
We have previously developed two potent chemical classes that inhibit the essential papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus (SARS-CoV). In this study, we applied a novel approach to identify small fragments that
Autor:
Christopher R. Jones, Tian Zhu, Kavankumar Patel, Kirk E. Hevener, Hao Lei, Michael E. Johnson, Hyun Lee
Publikováno v:
Journal of Chemical Information and Modeling. 53:560-572
We have developed a rigorous computational screening protocol to identify novel fragment-like inhibitors of N(5)-CAIR mutase (PurE), a key enzyme involved in de novo purine synthesis that represents a novel target for the design of antibacterial agen
Publikováno v:
Journal of Chemical Information and Modeling. 52:2245-2256
Drug discovery and design for inhibition of the Hepatitis C Virus (HCV) NS3/4A serine protease is a major challenge. The broad, shallow, and generally featureless nature of the active site makes it a difficult target for "hit" selection especially us
Autor:
Hyun Lee, Debbie C. Mulhearn, Lena Truong, Jaime Torres, Joseph L. Gatuz, Anuradha Mittal, Kavankumar Patel, Michael E. Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry
We have used a combination of virtual screening (VS) and high-throughput screening (HTS) techniques to identify novel, non-peptidic small molecule inhibitors against human SARS-CoV 3CLpro. A structure-based VS approach integrating docking and pharmac
Autor:
Hyunyoung Jeong, Yan-Yan Zhang, Lena Truong, Susan L. Uprichard, Tian Zhu, Gitanjali Subramanya, Michael E. Johnson, Kavankumar Patel, Joseph L. Gatuz, Hyun Lee, Kirk E. Hevener
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e75144 (2013)
PLoS ONE, Vol 8, Iss 10, p e75144 (2013)
Development of drug-resistant mutations has been a major problem with all currently developed Hepatitis C Virus (HCV) NS3/4A inhibitors, including the two FDA approved drugs, significantly reducing the efficacy of these inhibitors. The high incidence
Staphylococcus aureus is a pathogenic bacterium that causes a variety of mild to lethal human diseases. The rapid spread of multidrug-resistant strains makes the discovery of new antimicrobial agents critical. Dihydroorotase (PyrC), the third enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fd323da8c518a82bb242065e81cd07
https://europepmc.org/articles/PMC5663463/
https://europepmc.org/articles/PMC5663463/
Publikováno v:
Gastroenterology. 134:A-713