Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis

Autor: Chenge, J, Kavanagh, ME, Driscoll, MD, McLean, KJ, Young, DB, Cortes, T, Matak-Vinkovic, D, Levy, CW, Rigby, SEJ, Leys, D, Abell, C, Munro, AW

Publikováno v: Chenge, J, Kavanagh, M E, Driscoll, M, Mclean, K, Young, D B, Cortes, T, Matak-Vinkovic, D, Levy, C, Rigby, S, Leys, D, Abell, C & Munro, A 2016, ' Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis ' Scientific Reports, vol 6, 26628 . DOI: 10.1038/srep26628

Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB). The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CYP) enzymes, many of which are implicated in Mtb survival and pathogenicity in the human host. Bioinformatics analysis r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5f0631418849d29872cd964829124e24
https://researchonline.lshtm.ac.uk/id/eprint/2550068/1/srep26628.PMC4880925.pdf

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The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials.

Autor: Kavanagh ME; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada., Back S; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada., Chen V; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada., Glenn AJ; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA., Viscardi G; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada., Houshialsadat Z; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada., Sievenpiper JL; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Kendall CWC; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Jenkins DJA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Chiavaroli L; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.

Publikováno v: Nutrients [Nutrients] 2024 Aug 23; Vol. 16 (17). Date of Electronic Publication: 2024 Aug 23.

Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression.

Autor: Asantewaa G; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Tuttle ET; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Ward NP; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kang YP; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kim Y; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kavanagh ME; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.; Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Girnius N; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Chen Y; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA., Rodriguez K; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Hecht F; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Zocchi M; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Smorodintsev-Schiller L; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Scales TQ; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Taylor K; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Alimohammadi F; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA., Duncan RP; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Sechrist ZR; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Agostini-Vulaj D; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Schafer XL; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA., Chang H; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Smith ZR; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., O'Connor TN; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA., Whelan S; Leicester Cancer Research Centre, University of Leicester, Leicester, UK., Selfors LM; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Crowdis J; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Gray GK; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Bronson RT; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Brenner D; Experimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.; Immunology & Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark., Rufini A; Leicester Cancer Research Centre, University of Leicester, Leicester, UK.; Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy., Dirksen RT; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA., Hezel AF; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Huber AR; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Munger J; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Cravatt BF; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Vasiliou V; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA., Cole CL; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA., DeNicola GM; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Harris IS; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. isaac_harris@urmc.rochester.edu.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. isaac_harris@urmc.rochester.edu.; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA. isaac_harris@urmc.rochester.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 21; Vol. 15 (1), pp. 6152. Date of Electronic Publication: 2024 Jul 21.