Differential Patterns of Gut and Oral Microbiomes in Hispanic Individuals with Cognitive Impairment.

Autor: Wadop YN, Vasquez EL, Mathews JJ, Muhammad JAS, Mavarez RP, Satizabal C, Gonzales MM, Tanner J, Maestre G, Fonteh AN, Seshadri S, Kautz TF, Fongang B

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 29. Date of Electronic Publication: 2024 Jul 29.

Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy.

Autor: Walker JM; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA., Orr ME; Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Salisbury VA Medical Center, Salisbury, North Carolina, USA., Orr TC; Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Healthcare Innovations, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Thorn EL; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Christie TD; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Yokoda RT; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Vij M; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Ehrenberg AJ; Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, California, USA., Marx GA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Ronal M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., McKenzie AT; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Ronal M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Kauffman J; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Ronal M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Selmanovic E; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Wisniewski T; Department of Pathology, New York University Grossman School of Medicine, New York, New York, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.; Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA., Drummond E; Brain & Mind Center and School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia., White CL 3rd; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Crary JF; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Ronal M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Farrell K; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Ronal M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Kautz TF; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA., Daoud EV; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Richardson TE; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Feb; Vol. 20 (2), pp. 783-797. Date of Electronic Publication: 2023 Sep 30.

Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study.

Autor: Fongang B; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. fongang@uthscsa.edu.; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. fongang@uthscsa.edu.; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. fongang@uthscsa.edu., Satizabal C; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Kautz TF; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Wadop YN; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Muhammad JAS; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Vasquez E; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Mathews J; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Gireud-Goss M; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Saklad AR; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Himali J; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Beiser A; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Cavazos JE; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Mahaney MC; Department of Human Genetics, South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Maestre G; Department of Neurosciences and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., DeCarli C; Department of Neurology, Alzheimer's Disease Center, University of California, Davis, Sacramento, CA, USA., Shipp EL; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Vasan RS; Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, Section of Cardiovascular Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.; Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Boston University's Center for Computing and Data Sciences, Boston, MA, USA.; The University of Texas School of Public Health in San Antonio, San Antonio, TX, USA.; The Long School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Publikováno v: Scientific reports [Sci Rep] 2023 Aug 21; Vol. 13 (1), pp. 13622. Date of Electronic Publication: 2023 Aug 21.

Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels.

Autor: Sarnowski C; Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. Chloe.Sarnowski@uth.tmc.edu., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Logue M; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, USA.; Department of Psychiatry and Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA., Fornage M; University of Texas Health Sciences Center at Houston, Houston, TX, USA., Mishra A; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France., Ahmad S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Beiser AS; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Boerwinkle E; University of Texas Health Sciences Center at Houston, Houston, TX, USA., Bouteloup V; Centre Inserm U1219 Bordeaux Population Health, CIC1401-EC, Institut de Santé Publique, d'Epidémiologie et de Développement, Université de Bordeaux, CHU de Bordeaux, Pôle Santé Publique, Bordeaux, France., Chouraki V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Damotte V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France., DeCarli CS; Department of Neurology and Center for Neuroscience, University of California at Davis, Davis, CA, USA., DeStefano AL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Djoussé L; Department of Medicine, Division of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Fohner AE; Institute of Public Health Genetics and Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Franz CE; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA., Kautz TF; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France., Lyons MJ; Department of Psychology and Brain Sciences, Boston University, Boston, MA, USA., Mosley TH; University of Mississippi Medical Center, Jackson, MS, USA., Mukamal KJ; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Pase MP; Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.; Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Portilla Fernandez EC; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Rissman RA; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Satizabal CL; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Vasan RS; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Preventive Medicine & Epidemiology, Boston University School of Medicine, Boston, MA, USA., Yaqub A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Debette S; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.; Bordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux, France., Dufouil C; Bordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux, France., Launer LJ; National Institute on Aging, Baltimore, MD, USA., Kremen WS; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA., Longstreth WT; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Seshadri S; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.

Publikováno v: Communications biology [Commun Biol] 2022 Apr 08; Vol. 5 (1), pp. 336. Date of Electronic Publication: 2022 Apr 08.

Negeviruses Reduce Replication of Alphaviruses during Coinfection.

Autor: Patterson EI; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada., Kautz TF; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas, USA., Contreras-Gutierrez MA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; Tecnológico de Antioquia, Institución Universitaria, Medellin, Colombia.; Grupo de Investigación en Sistemática Molecular, Universidad Nacional de Colombia, Medellin, Colombia., Guzman H; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Tesh RB; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Hughes GL; Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Forrester NL; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.; School of Life Sciences, University of Keele, Keele, United Kingdom.

Publikováno v: Journal of virology [J Virol] 2021 Jun 24; Vol. 95 (14), pp. e0043321. Date of Electronic Publication: 2021 Jun 24.