Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Kaustav, Biswas"'
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Charles W. Wright, Naomi Li, Lynsey Shaffer, Armetta Hill, Nicolas Boyer, Stephen E. Alves, Sriraman Venkataraman, Kaustav Biswas, Linda A. Lieberman, Sina Mohammadi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Disruptions in the gut epithelial barrier can lead to the development of chronic indications such as inflammatory bowel disease (IBD). Historically, barrier function has been assessed in cancer cell lines, which do not contain all human inte
Externí odkaz:
https://doaj.org/article/53dd0fbf350741229b237e3cc1522057
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro Aronica, Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Brian Henry, Marika Nestor, Chandra S Verma, David Lane, Tomi Sawyer, Robert Garbaccio, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W Johannes, Anthony William Partridge
Stapled α-helical peptides can bind to and modulate historically intractable targets while addressing the traditional liabilities associated with peptide therapeutics. However, their pipeline advancement has been impeded by the challenges of identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f15998d22633b086d54b5c6b03932d
https://doi.org/10.1101/2023.02.25.530030
https://doi.org/10.1101/2023.02.25.530030
Publikováno v:
ACS Symposium Series. :ix-xi
Autor:
Kristal Kaan, Nicole Boo, Yu-Chi Angela Juang, Chandra S. Verma, Kaustav Biswas, Ruchia Duggal, Christopher J. Brown, Bhvana Bhatt, Chunhui Huang, Simon Ng, Ahmad Sadruddin, Nianyu Jason Li, Srinivasaraghavan Kannan, Shuhui Lim, Xiang Yu, Charles W. Johannes, Andrea M. Peier, Anthony W. Partridge, Erjia Wang, Lan Ge, Michael Garrigou, Pooja Gopal, Gireedhar Venkatachalam, Brian Henry, Nicolas Boyer, Khong Ming Peh, Tsz Ying Yuen, Raymond J. Gonzalez, Feifei Chen, Tomi K. Sawyer, Alexander Stoeck, Peter Orth, David P. Lane
Publikováno v:
Chemical Science
Macrocyclic peptides have the potential to address intracellular protein–protein interactions (PPIs) of high value therapeutic targets that have proven largely intractable to small molecules. Here, we report broadly applicable lessons for applying
Autor:
Charles W. Wright, Naomi Li, Lynsey Shaffer, Armetta Hill, Nicolas Boyer, Stephen Alves, Sriram Venkat, Kaustav Biswas, Linda A. Lieberman, Sina Mohammadi
Disruptions in the gut epithelial barrier can lead to the development of chronic indications such as inflammatory bowel disease (IBD). Historically, barrier function has been assessed in cancer cell lines, which do not contain all human intestinal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a5c487ef12d61187d57398773a1b32a
https://doi.org/10.1101/2022.12.16.520780
https://doi.org/10.1101/2022.12.16.520780
Autor:
Bryan D Moyer, Justin K Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau, John B Jordan, Josie H Lee, Dong Liu, Jason Long, Kelvin Sham, Licheng Shi, Reto Stöcklin, Bin Wu, Ruoyuan Yin, Violeta Yu, Anruo Zou, Kaustav Biswas, Les P Miranda
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196791 (2018)
Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series, electrophy
Externí odkaz:
https://doaj.org/article/05d6c798f5064771a7180e9f1fa3d097
Autor:
Sandra L. Ross, Kaustav Biswas, James Rottman, Jennifer R. Allen, Jason Long, Les P. Miranda, Aaron Winters, Tara L. Arvedson
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes. Inflammatory disorders and malignancies are often associated with high hepcidin le
Externí odkaz:
https://doaj.org/article/b4f73a01607546a1b5d51be90e1d227f
Autor:
Tomi K. Sawyer, Kaustav Biswas
Publikováno v:
ACS Symposium Series ISBN: 9780841297616
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc76c1fa2e8729c662edff900b20896
https://doi.org/10.1021/bk-2022-1417.ch001
https://doi.org/10.1021/bk-2022-1417.ch001
Autor:
Michael Garrigou, Bérengère Sauvagnat, Ruchia Duggal, Nicole Boo, Pooja Gopal, Jennifer M. Johnston, Anthony Partridge, Tomi Sawyer, Kaustav Biswas, Nicolas Boyer
Publikováno v:
Journal of medicinal chemistry. 65(13)
Macrocyclic peptides can disrupt previously intractable protein-protein interactions (PPIs) relevant to oncology targets such as KRAS. Early hits often lack cellular activity and require meticulous improvement of affinity, permeability, and metabolic