Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kausik Si"'
Autor:
Raquel Barajas-Azpeleta, Kausik Si
Publikováno v:
eLife, Vol 8 (2019)
Progeny can inherit parental experiences through altered brain chemistry.
Externí odkaz:
https://doaj.org/article/79ddecb193904f85819e085b477a9627
Autor:
Raquel Barajas-Azpeleta, Jianping Wu, Jason Gill, Ryan Welte, Chris Seidel, Sean McKinney, Stephane Dissel, Kausik Si
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007440 (2018)
Antimicrobial peptides act as a host defense mechanism and regulate the commensal microbiome. To obtain a comprehensive view of genes contributing to long-term memory we performed mRNA sequencing from single Drosophila heads following behavioral trai
Externí odkaz:
https://doaj.org/article/c1be5beb842b453bbd8bbc2263272ae6
Autor:
John P McGinnis, Huoqing Jiang, Moutaz Ali Agha, Consuelo Perez Sanchez, Jeff Lange, Zulin Yu, Frederic Marion-Poll, Kausik Si
Publikováno v:
eLife, Vol 5 (2016)
Reward perception guides all aspects of animal behavior. However, the relationship between the perceived value of a reward, the latent value of a reward, and the behavioral response remains unclear. Here we report that, given a choice between two swe
Externí odkaz:
https://doaj.org/article/3ff013f324e347ac80d59c23d8a6a3fd
Autor:
Rubén Hervás, Liying Li, Amitabha Majumdar, María Del Carmen Fernández-Ramírez, Jay R Unruh, Brian D Slaughter, Albert Galera-Prat, Elena Santana, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Sergio Casas-Tintó, Margarita Menéndez, Douglas V Laurents, Kausik Si, Mariano Carrión-Vázquez
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002361 (2016)
Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like state of the neuronal RNA binding protein Orb2 in Drosophila was recently implicated in memo
Externí odkaz:
https://doaj.org/article/77f95cb5f9284cf6befdeef4b438bc58
Autor:
Erica White-Grindley, Liying Li, Repon Mohammad Khan, Fengzhen Ren, Anita Saraf, Laurence Florens, Kausik Si
Publikováno v:
PLoS Biology, Vol 12, Iss 2, p e1001786 (2014)
How learned experiences persist as memory for a long time is an important question. In Drosophila the persistence of memory is dependent upon amyloid-like oligomers of the Orb2 protein. However, it is not clear how the conversion of Orb2 to the amylo
Externí odkaz:
https://doaj.org/article/a4f75a4ae5674812a4e4abafc81af6a4
Autor:
Mark E. Parrish, Robb Krumlauf, Bony De Kumar, Laurence Florens, Joan W. Conaway, Ariel Paulson, Narendra Pratap Singh, Ying Zhang, Kausik Si
Publikováno v:
Genes Dev
Gene duplication and divergence is a major driver in the emergence of evolutionary novelties. How variations in amino acid sequences lead to loss of ancestral activity and functional diversification of proteins is poorly understood. We used cross-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce9a1cd711cb5623d5d0f3c2caa373d
https://doi.org/10.1101/gad.342329.120
https://doi.org/10.1101/gad.342329.120
Autor:
Younshim Park, James A. J. Fitzpatrick, Sjors H.W. Scheres, Wenjuan Zhang, Alexey G. Murzin, Kausik Si, Rubén Hervás, Michael J. Rau
Publikováno v:
Science. 367:1230-1234
How amyloid can be a substrate of memory Formation of memories requires changes in the molecular composition of the synapse. How these changes occur and what maintains this altered synaptic composition so that memory can persist are unknown. Hervas e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::089d5e97156f05f268a3e3d53c07ca70
https://doi.org/10.1126/science.aba3526
https://doi.org/10.1126/science.aba3526
Publikováno v:
SSRN Electronic Journal.
One common consequence of cytosolic proteostasis stress is the formation of protein aggregates that are attached to the mitochondrial outer membrane. Although many cytosolic factors have been shown to regulate the aggregation of cytosolic proteins, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0077ef6e63526fa0b1b05e3924b54f7c
https://doi.org/10.2139/ssrn.3808300
https://doi.org/10.2139/ssrn.3808300
Autor:
Kausik Si
A synapse-based mechanism of formation and persistence of long-term memory (LTM) entails some unique mechanistic challenges. It requires experience-dependent changes in synapse composition, function, and number. These changes must be specific to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3768a4c9fef557f3b8534ee9900b3030
https://doi.org/10.1093/oxfordhb/9780190686307.013.11
https://doi.org/10.1093/oxfordhb/9780190686307.013.11
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6910, p 6910 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6910, p 6910 (2020)
Huntington’s disease is a progressive, autosomal dominant, neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. As a result, the translated protein, huntingtin, contains an abnormally long polyglutamine stretch that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc0dc9def70be13fc83c56d198850c5
http://europepmc.org/articles/PMC7555547
http://europepmc.org/articles/PMC7555547