Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kaushik N. Thakkar"'
Autor:
James D. Brooks, Rie von Eyben, Yang Li, Amato J. Giaccia, Anh N. Diep, Donna M. Peehl, James Broughton, Jose A. Seoane, Yiren Xiao, Jiangbin Ye, Erinn B. Rankin, Hongjuan Zhao, David L. Dill, Kaushik N. Thakkar, Subarna Sinha, Thomas J. Metzner, John T. Leppert, Christina Curtis
Publikováno v:
Proceedings of the National Academy of Sciences. 117:21441-21449
Loss of the von Hippel–Lindau (VHL) tumor suppressor is a hallmark feature of renal clear cell carcinoma. VHL inactivation results in the constitutive activation of the hypoxia-inducible factors (HIFs) HIF-1 and HIF-2 and their downstream targets,
Autor:
Marta Vilalta, Adam J. Krieg, Caiyun G. Li, Eui Jung Moon, Amato J. Giaccia, Jen-Tsan Chi, Edward E. Graves, Jacob G. Kirkland, Stephano S. Mello, Anh N. Diep, Marjan Rafat, Yu Miao, Edward L. LaGory, Laura D. Attardi, Kaushik N. Thakkar, Laura Castellini, Ik Jae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b64acea8911667a49665037069c39
https://doi.org/10.1038/s41467-021-24631-6
https://doi.org/10.1038/s41467-021-24631-6
Autor:
Yu Xu, Karlene A. Cimprich, Ryan K. Kim, Anh N. Diep, Caiyun G. Li, Kaushik N. Thakkar, Yiren Xiao, Julien Bacal, Amato J. Giaccia, Eui Jung Moon, Joshua Bloomstein, Erinn B. Rankin, Joshua C. Saldivar, Quynh-Thu Le, Manal Mehibel
Publikováno v:
J Clin Invest
Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficie
Autor:
Yiren, Xiao, Kaushik N, Thakkar, Hongjuan, Zhao, James, Broughton, Yang, Li, Jose A, Seoane, Anh N, Diep, Thomas J, Metzner, Rie, von Eyben, David L, Dill, James D, Brooks, Christina, Curtis, John T, Leppert, Jiangbin, Ye, Donna M, Peehl, Amato J, Giaccia, Subarna, Sinha, Erinn B, Rankin
Publikováno v:
Proc Natl Acad Sci U S A
Loss of the von Hippel–Lindau (VHL) tumor suppressor is a hallmark feature of renal clear cell carcinoma. VHL inactivation results in the constitutive activation of the hypoxia-inducible factors (HIFs) HIF-1 and HIF-2 and their downstream targets,
Autor:
Teddy Tat Chi Yang, Tiane Li, Yu Rebecca Miao, Bo Wei, Anh N. Diep, Haizea Alemany, Eui Jung Moon, Wei Huang, Amato J. Giaccia, Mihalis Kariolis, Yu Xu, Saravanan Nandagopal, Kaushik N. Thakkar, Yiren Xiao, Jin Qian, Erinn B. Rankin, Gerald Maxwell Cherf, Wenhua Yu
Publikováno v:
Clin Cancer Res
Purpose: Ovarian cancer represents a major clinical hurdle for immune checkpoint blockade (ICB), with reported low patient response rates. We found that the immune checkpoint ligand PD-L2 is robustly expressed in patient samples of ovarian cancers an
Neutralizing PD-L1 and PD-L2 Enhances the Efficacy of Immune Checkpoint Inhibitors in Ovarian Cancer
Autor:
Teddy Tat Chi Yang, Haizea Alemany, Amato J. Giaccia, Erinn B. Rankin, Saravanan Nandagopal, Eui Jung Moon, Wenhua Yu, Gerald Maxwell Cherf, Kaushik N. Thakkar, Yiren Xiao, Yu Rebecca Miao, Yu Xu, Anh N. Diep, Mihalis Kariolis, Tiane Li, Jin Qian, Bo Wei, Wei Huang
Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have improved for a number of solid tumors. Unfortunately, ovarian cancer represents a major clinical hurdle for immune checkpoint blockade (ICB) with reported low patient response rates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3132f8be2e8de8c900623bafc7f0ee
https://doi.org/10.1101/2020.01.19.911941
https://doi.org/10.1101/2020.01.19.911941
Autor:
Jannik N. Andersen, Sharon Y.R. Dent, Michelle Craig Barton, Srikanth Appikonda, Parantu K. Shah, Kaushik N. Thakkar
Publikováno v:
Journal of Biological Chemistry. 293:7476-7485
Proteins with domains that recognize and bind post-translational modifications (PTMs) of histones are collectively termed epigenetic readers. Numerous interactions between specific reader protein domains and histone PTMs and their regulatory outcomes
Autor:
Manal Mehibel, Joshua C. Saldivar, Kaushik N. Thakkar, Siren Xiao, Jimmy Xu, Anh N. Diep, Amato J. Giaccia, Q.T. Le, Jung Moon, Karlene A. Cimprich, Ryan Kim, Julien Bacal, Grace Caiyun Li, Joshua Bloomstein, Erinn B. Rankin
Publikováno v:
Clinical Cancer Research. 27:IA-003
Severe hypoxia causes resistance to conventional chemotherapy and has been reported to synergize with PARP inhibitors (PARPi) through suppression of homologous recombination (HR). While this synergistic killing is true at oxygen levels less than 0.5%
Publikováno v:
Drug Discovery Today: Technologies. 19:57-63
Tripartite Motif-containing protein 24 (TRIM24) functions as an E3 ligase targeting p53 for ubiquitination, a histone 'reader' that interacts with a specific signature of histone post-translational modifications and a co-regulator of nuclear receptor
Autor:
Jimmy Xu, Anh N. Diep, Manal Mehibel, Kaushik N. Thakkar, Amato J. Giaccia, Caiyun G. Li, Erinn B. Rankin, Yiren Xiao
Publikováno v:
Journal of Clinical Oncology. 37:e14715-e14715
e14715 Background: PARP inhibitors (PARPi) have demonstrated activity in HR deficient tumors through synthetic lethality. However, their clinical efficacy has not been highly promising, with response rates ranging between 30-60% for Olaparib, Talazop