Zobrazeno 1 - 10
of 1 907
pro vyhledávání: '"Kaushansky A"'
Autor:
Wei, Ling, Barrie, Umaru, Aloisio, Gina M., Khuong, Francis T.H., Arang, Nadia, Datta, Arani, Kaushansky, Alexis, Wetzel, Dawn M.
Publikováno v:
In Molecular & Biochemical Parasitology December 2024 260
Autor:
Minhua Su, Tom Fleisher, Inna Grosheva, Melanie Bokstad Horev, Malgorzata Olszewska, Camilla Ciolli Mattioli, Haim Barr, Alexander Plotnikov, Silvia Carvalho, Yoni Moskovich, Mark D. Minden, Noa Chapal-Ilani, Alexander Wainstein, Eirini P. Papapetrou, Nili Dezorella, Tao Cheng, Nathali Kaushansky, Benjamin Geiger, Liran I. Shlush
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109443- (2024)
Summary: Spliceosome machinery mutations are common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking. In the current study, we used an in vitro high-throughput drug screen among four differ
Externí odkaz:
https://doaj.org/article/0f0b14d6b7ce4b4cbbdae7d1354a29e0
Autor:
Natasha M. Bourgeois, Ling Wei, Nhi N. T. Ho, Maxwell L. Neal, Denali Seferos, Tinotenda Tongogara, Fred D. Mast, John D. Aitchison, Alexis Kaushansky
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionDengue is an arboviral disease causing severe illness in over 500,000 people each year. Currently, there is no way to constrain dengue in the clinic. Host kinase regulators of dengue virus (DENV) infection have the potential to be disrupt
Externí odkaz:
https://doaj.org/article/df199684a6b74f57a0f955ed2a41a8e2
Autor:
Diego Rodríguez-Hernández, Kamalakannan Vijayan, Rachael Zigweid, Michael K. Fenwick, Banumathi Sankaran, Wanlapa Roobsoong, Jetsumon Sattabongkot, Elizabeth K. K. Glennon, Peter J. Myler, Per Sunnerhagen, Bart L. Staker, Alexis Kaushansky, Morten Grøtli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) is an essential eukaryotic enzyme and a validated drug target f
Externí odkaz:
https://doaj.org/article/e6b4e2ed37a24eb3abab00e4f5cd5476
Autor:
Su, Minhua, Fleischer, Tom, Grosheva, Inna, Horev, Melanie Bokstad, Olszewska, Malgorzata, Mattioli, Camilla Ciolli, Barr, Haim, Plotnikov, Alexander, Carvalho, Silvia, Moskovich, Yoni, Minden, Mark D., Chapal-Ilani, Noa, Wainstein, Alexander, Papapetrou, Eirini P., Dezorella, Nili, Cheng, Tao, Kaushansky, Nathali, Geiger, Benjamin, Shlush, Liran I.
Publikováno v:
In iScience 19 April 2024 27(4)
Autor:
Kaushansky, Kenneth1 (AUTHOR) kenneth.kaushansky@stonybrook.edu
Publikováno v:
Biomolecules (2218-273X). Apr2024, Vol. 14 Issue 4, p489. 14p.
The supercooled Stefan problem and its variants describe the freezing of a supercooled liquid in physics, as well as the large system limits of systemic risk models in finance and of integrate-and-fire models in neuroscience. Adopting the physics ter
Externí odkaz:
http://arxiv.org/abs/2010.05281
Autor:
Zephyr Pitre, Tess Seltzer, Cecilia Kalthoff, Maria Benitez-Cortez, Conrad Yee, Elizabeth K.K. Glennon, Veronica I. Primavera, Alexis Kaushansky
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102621- (2023)
Summary: Live mosquitoes are required to comprehensively study vector-borne diseases, including transmission. Traditional mosquito-rearing protocols are laborious and time consuming. Here, we present a protocol for assembling and implementing a parti
Externí odkaz:
https://doaj.org/article/92d6270c29e0492799544d65e4f9a0e2
Akademický článek
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Autor:
N. Zioni, A. Akhiad Bercovich, N. Chapal-Ilani, Tal Bacharach, N. Rappoport, A. Solomon, R. Avraham, E. Kopitman, Z. Porat, M. Sacma, G. Hartmut, M. Scheller, C. Muller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, Liran I. Shlush
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Both fatty bone marrow (FBM) and somatic mutations in hematopoietic stem cells (HSCs), also termed clonal hematopoiesis (CH) accumulate with human aging. However it remains unclear whether FBM can modify the evolution of CH. To address this
Externí odkaz:
https://doaj.org/article/9630880f8f224249bf53ebc74fbd8b46