Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kaushalya Kulathunga"'
Autor:
Takeshi Kawamata, Arata Wakimoto, Takanobu Nishikawa, Masaya Ikezawa, Michito Hamada, Yuri Inoue, Kaushalya Kulathunga, Filiani Natalia Salim, Maho Kanai, Teppei Nishino, Kyle Gentleman, Chang Liu, Bryan J. Mathis, Nozomu Obana, Shinji Fukuda, Satoru Takahashi, Yuki Taya, Satoshi Sakai, Yuji Hiramatsu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Natto, known for its high vitamin K content, has been demonstrated to suppress atherosclerosis in large-scale clinical trials through a yet-unknown mechanism. In this study, we used a previously reported mouse model, transplanting the bone m
Externí odkaz:
https://doaj.org/article/5cbb993c5bf84659bf857e0120cff215
Autor:
Manoj Kumar Yadav, Megumi Ishida, Natalia Gogoleva, Ching-Wei Liao, Filiani Natalia Salim, Maho Kanai, Akihiro Kuno, Takuto Hayashi, Zeynab Javanfekr Shahri, Kaushalya Kulathunga, Omar Samir, Wenxin Lyu, Olivia Olivia, Evaristus C. Mbanefo, Satoru Takahashi, Michito Hamada
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113978- (2024)
Summary: Transcription factor MAFB regulates various homeostatic functions of macrophages. This study explores the role of MAFB in brown adipose tissue (BAT) thermogenesis using macrophage-specific Mafb-deficient (Mafbf/f::LysM-Cre) mice. We find tha
Externí odkaz:
https://doaj.org/article/04c3e97182974a54b4e1a1359362e59c
Autor:
Kaushalya Kulathunga, Arata Wakimoto, Yukiko Hiraishi, Manoj Kumar Yadav, Kyle Gentleman, Eiji Warabi, Tomoki Sakasai, Yoshihiro Miwa, Seiya Mizuno, Satoru Takahashi, Michito Hamada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Non-alcoholic fatty liver disease (NAFLD) constitutes a metabolic disorder with high worldwide prevalence and increasing incidence. The inflammatory progressive state, non-alcoholic steatohepatitis (NASH), leads to liver fibrosis and carcino
Externí odkaz:
https://doaj.org/article/1e3d06d303874791b7d8c5107ec033d1
Publikováno v:
Indian Journal of Animal Sciences, Vol 92, Iss 10 (2022)
Self renewal and proliferation ability of spermatogonial stem cells (SSCs) support spermatogenesis during adult life. Theoretically, these stem cells can be utilized for transmission of genetic information to descendants via testicular transplantatio
Externí odkaz:
https://doaj.org/article/561211cefca44b98b95e466981c0ef69
Autor:
Hyojung Jeon, Keigo Asano, Arata Wakimoto, Kaushalya Kulathunga, Mai Thi Nhu Tran, Megumi Nakamura, Tomomasa Yokomizo, Michito Hamada, Satoru Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract In order to increase the contribution of donor HSC cells, irradiation and DNA alkylating agents have been commonly used as experimental methods to eliminate HSCs for adult mice. But a technique of HSC deletion for mouse embryo for increase c
Externí odkaz:
https://doaj.org/article/98c72039521d4ef6b1e5ffbb80d0d82b
Autor:
Kaushalya Kulathunga, Michito Hamada, Yukiko Hiraishi, Mao Otake, Mai Thi Nhu Tran, Olivia Cheng, Junko Tanaka, Tomoki Sakasai, Shota Sakaguchi, Yuka Sugiyama, Bernd K. Fleischmann, Satoru Takahashi, Yoshihiro Miwa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract By using near-infrared fluorescent protein (iRFP)-expressing hematopoietic cells, we established a novel, quantitative, in vivo, noninvasive atherosclerosis imaging system. This murine atherosclerosis imaging approach targets macrophages exp
Externí odkaz:
https://doaj.org/article/4d61aeb86c6e4b90a0b29fc94a27c589
Autor:
Mai Thi Nhu Tran, Michito Hamada, Hyojung Jeon, Risako Shiraishi, Keigo Asano, Motochika Hattori, Megumi Nakamura, Yuki Imamura, Yuki Tsunakawa, Risa Fujii, Toshiaki Usui, Kaushalya Kulathunga, Christina-Sylvia Andrea, Ryusuke Koshida, Risa Kamei, Yurina Matsunaga, Makoto Kobayashi, Hisashi Oishi, Takashi Kudo, Satoru Takahashi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contr
Externí odkaz:
https://doaj.org/article/8ad6548fe15640be8a3fcc672a1b03f2
Autor:
Manoj Kumar Yadav, Hyojung Jeon, Michito Hamada, Akari Teramoto, Satoru Takahashi, Megumi Nakamura, Omar Samir, Takashi Kudo, Kaushalya Kulathunga, Manabu Kusakabe, Aya Nakane-Otani, Yuki Tsunakawa, Yuri Inoue
Publikováno v:
Biochemical and Biophysical Research Communications. 521:590-595
The transcription factor MafB is specifically expressed in macrophages. We have recently demonstrated that MafB is expressed in anti-inflammatory alternatively activated M2 macrophages in vitro. Tumor-associated macrophages (TAMs) are a subset of M2
Publikováno v:
Journal of Hepatology. 77:S702-S703
Autor:
Kaushalya Kulathunga, Shayida Maimaiti, Masami Ojima, Hisashi Oishi, Ryusuke Koshida, Satoru Takahashi
Publikováno v:
Experimental Animals. 68:435-442
Mammalian postnatal growth is regulated primarily by the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis. MafB is a basic leucine zipper (bZip) transcription factor that has pleiotropic functions. Although MafB plays a critical role in