Výsledky vyhledávání - "Kaushal S. Gandhi"

Akademický článek

A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis.

Autor: Carlos Riveros, Drew Mellor, Kaushal S Gandhi, Fiona C McKay, Mathew B Cox, Regina Berretta, S Yahya Vaezpour, Mario Inostroza-Ponta, Simon A Broadley, Robert N Heard, Stephen Vucic, Graeme J Stewart, David W Williams, Rodney J Scott, Jeanette Lechner-Scott, David R Booth, Pablo Moscato, ANZgene Multiple Sclerosis Genetics Consortium

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14176 (2010)

BackgroundSeveral lines of evidence suggest that transcription factors are involved in the pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole network has been elusive. One of the reasons is that there are several clinical subty

Externí odkaz: https://doaj.org/article/57cf07fc99e548b88dcd763073a08da1

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Akademický článek

A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis.

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13454 (2010)

We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we identified seven SNPs that we

Externí odkaz: https://doaj.org/article/666c12ee17314e0d830ff51e46de6064

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Akademický článek

MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood.

Autor: Mathew B Cox, Murray J Cairns, Kaushal S Gandhi, Adam P Carroll, Sophia Moscovis, Graeme J Stewart, Simon Broadley, Rodney J Scott, David R Booth, Jeannette Lechner-Scott, ANZgene Multiple Sclerosis Genetics Consortium

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12132 (2010)

It is well established that Multiple Sclerosis (MS) is an immune mediated disease. Little is known about what drives the differential control of the immune system in MS patients compared to unaffected individuals. MicroRNAs (miRNAs) are small non-cod

Externí odkaz: https://doaj.org/article/08421e7245d1407d9ac2d8dacc401bf5

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Akademický článek

Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis.

Autor: Kaushal S Gandhi, Fiona C McKay, Eve Diefenbach, Ben Crossett, Stephen D Schibeci, Robert N Heard, Graeme J Stewart, David R Booth, Jonathan W Arthur

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10484 (2010)

Interferon beta (IFNbeta) is the most common immunomodulatory treatment for relapsing-remitting multiple sclerosis (RRMS). However, some patients fail to respond to treatment. In this study, we identified putative clinical response markers in the ser

Externí odkaz: https://doaj.org/article/8c6ea329e8b54c66ae614ed5dc5195ca

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Functionally Significant Differences in Expression of Disease-Associated IL-7 Receptor α Haplotypes in CD4 T Cells and Dendritic Cells

Autor: David R. Booth, Stephen D. Schibeci, Graeme J. Stewart, Robert Heard, Edwin Hoe, Kaushal S. Gandhi, Fiona C. McKay

Publikováno v: The Journal of Immunology. 184:2512-2517

Common genetic variants of IL-7 receptor α (IL-7Rα) have recently been shown to affect susceptibility to multiple sclerosis (MS) and type 1 diabetes, and survival following bone marrow transplantation. Transcription of the gene produces two dominan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6a95e13657f1e2e512b72ac0bcbc72
https://doi.org/10.4049/jimmunol.0902900

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BAFF is a Biological Response Marker to IFN-β Treatment in Multiple Sclerosis

Autor: Graeme J. Stewart, Robert Heard, Fiona C. McKay, David R. Booth, Stephen D. Schibeci, Jonathan W. Arthur, Kaushal S. Gandhi

Publikováno v: Journal of Interferon & Cytokine Research. 28:529-540

Multiple sclerosis (MS) is a complex autoimmune disease characterized by the destruction of the myelin sheath of neurons. Interferon beta (IFN-beta) is currently the major drug used to treat MS. Some patients fail to respond to this treatment, in som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ed557ba4f82c043cce2921459883f4
https://doi.org/10.1089/jir.2008.0007

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A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13454 (2010)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f933a154a205e62fad90baeacf2bc4e6
http://europepmc.org/articles/PMC2964313

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First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia

Autor: Eve Diefenbach, Amit Kapur, Bin Wang, Rejane Rua, Ben Crossett, Thomas Ng, Sieu L. Tran, Helen Rizos, Kaushal S. Gandhi, Li Zhou, Bruce J. Brew, Nitin K. Saksena

Publikováno v: Molecular Neurodegeneration, Vol 5, Iss 1, p 27 (2010)
Molecular Neurodegeneration

Background The pathogenesis of HIV-associated dementia (HAD) is poorly understood. To date, detailed proteomic fingerprinting directly from autopsied brain tissues of HAD and HIV non-dementia patients has not been performed. Result Here, we have anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e7f447a5014dea6f37e4ccd60a8fac
http://www.molecularneurodegeneration.com/content/5/1/27

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The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis

Autor: Kaushal S, Gandhi, Fiona C, McKay, Mathew, Cox, Carlos, Riveros, Nicola, Armstrong, Robert N, Heard, Steve, Vucic, David W, Williams, Jim, Stankovich, Matthew, Brown, Patrick, Danoy, Graeme J, Stewart, Simon, Broadley, Pablo, Moscato, Jeannette, Lechner-Scott, Rodney J, Scott, David R, Booth, Melanie, Bahlo

Publikováno v: Human molecular genetics. 19(11)

Multiple sclerosis (MS) is an autoimmune disease with a genetic component, caused at least in part by aberrant lymphocyte activity. The whole blood mRNA transcriptome was measured for 99 untreated MS patients: 43 primary progressive MS, 20 secondary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9774e0c8ac181fba4368886c849d5fda
https://pubmed.ncbi.nlm.nih.gov/20190274

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Genome-wide analysis of primary peripheral blood mononuclear cells from HIV + patients-pre-and post- HAART show immune activation and inflammation the main drivers of host gene expression

Autor: Nitin K. Saksena, Kaushal S. Gandhi, Wayne B. Dyer, Priyanka Gupta, Viviane Conceicao

Publikováno v: Molecular and cellular therapies

Background Although the host gene expression in the context of HIV has been explored by several studies, it remains unclear how HIV is able to manipulate and subvert host gene machinery before and after highly active antiretroviral therapy (HAART) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012f77b0bafaa7897639e4839f1a004a
https://doi.org/10.1186/2052-8426-2-11

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