Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kausalya Murthy"'
Autor:
Sangeetha Iyer, Feba S. Sam, Nina DiPrimio, Graeme Preston, Jan Verheijen, Kausalya Murthy, Zachary Parton, Hillary Tsang, Jessica Lao, Eva Morava, Ethan O. Perlstein
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 11 (2019)
Phosphomannomutase 2 deficiency, or PMM2-CDG, is the most common congenital disorder of glycosylation and affects over 1000 patients globally. There are no approved drugs that treat the symptoms or root cause of PMM2-CDG. To identify clinically actio
Externí odkaz:
https://doaj.org/article/73f5388e14c348678bb225c904595475
Autor:
Amruta Vasudevan, Reshma Maiya, Keertana Venkatesh, Vinod Kumar, Parul Sood, Kausalya Murthy, Sandhya P. Koushika, Gautam I. Menon
Publikováno v:
Journal of Cell Science.
Stationary clusters of vesicles are a prominent feature of axonal transport, but little is known about their physiological and functional relevance to axonal transport. We investigate the role of vesicle motility characteristics in modulating the for
Autor:
Venkatesh K, Parul Sood, Gautam I. Menon, Amruta Vasudevan, Kumar, Sandhya P. Koushika, Maiya R, Kausalya Murthy
Molecular motors drive the directed transport of presynaptic vesicles along the narrow axons of nerve cells. Stationary clusters of such vesicles are a prominent feature of axonal transport, but little is known about their physiological and functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c8cc7f9ac6ea14d37b2800111dd1986
https://doi.org/10.1101/2021.03.12.434740
https://doi.org/10.1101/2021.03.12.434740
Autor:
Andrea Hadjikyriacou, Sangeetha Iyer, Joshua D. Mast, Nina DiPrimio, John Concannon, Joshua Ketterman, Frederic Sigoillot, Tamy P. Rodriguez, Feba S. Sam, Hillary Tsang, Madeleine Prangley, Julide Bilen, Kausalya Murthy, Tom A. Hartl, Christophe Antczak, Jeremy L Jenkins, Nathan T. Ross, Beat Nyfeler, Rishi K. Jain, John A. Tallarico, Ethan O. Perlstein, Stephen M. Canham
Invertebrate model organisms (the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster) are valuable tools to bridge the gap between traditional in vitro discovery and preclinical animal models. Invertebrate model organisms are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96724114f0536d920b8fc593b93f63bf
https://doi.org/10.1101/2021.03.05.434120
https://doi.org/10.1101/2021.03.05.434120
Autor:
Gautam I. Menon, Kausalya Murthy, Parul Sood, Michael L. Nonet, Vinod Kumar T, Sandhya P. Koushika
Publikováno v:
Traffic (Copenhagen, Denmark). 19(3)
Steady axonal cargo flow is central to the functioning of healthy neurons. However, a substantial fraction of cargo in axons remains stationary up to several minutes. We examine the transport of precursors of synaptic vesicles (pre-SVs), endosomes an
Autor:
Gautam I. Menon, Sandhya P. Koushika, Parul Sood, Vinod Kumar T, Kausalya Murthy, Michael L. Nonet
Steady axonal cargo flow is central to the functioning of healthy neurons. However, a substantial fraction of cargo in axons remains stationary across a broad distribution of times. We examine the transport of pre-synaptic vesicles (pre-SVs), endosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19685f38eb09d2711204941b47ef4a98
https://doi.org/10.1101/151761
https://doi.org/10.1101/151761
Publikováno v:
Traffic. 12:89-101
Axonal transport is an essential process that carries cargoes in the anterograde direction to the synapse and in the retrograde direction back to the cell body. We have developed a novel in vivo method to exclusively mark and dynamically track retrog
Autor:
Kausalya Murthy, Patricia Wadsworth
Publikováno v:
Journal of Cell Science. 121:2350-2359
Microtubules stimulate contractile-ring formation in the equatorial cortex and simultaneously suppress contractility in the polar cortex; how they accomplish these differing activities is incompletely understood. We measured the behavior of GFP-actin
Publikováno v:
Journal of Cell Science. 118:4113-4122
Mammalian cells develop a polarized morphology and migrate directionally into a wound in a monolayer culture. To understand how microtubules contribute to these processes, we used GFP-tubulin to measure dynamic instability and GFP-EB1, a protein that
Autor:
Patricia Wadsworth, Kausalya Murthy
Publikováno v:
Current Biology. 15(8):724-731
Summary Background: The assembly of an F-actin- and myosin-II-containing contractile ring (CR) is required for cytokinesis in eukaryotic cells. Interactions between myosin II and actin in the ring are believed to generate the force that constricts th