Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Kaur Alasoo"'
Publikováno v:
HGG Advances, Vol 5, Iss 4, Pp 100348- (2024)
Summary: Identifying causal genes underlying genome-wide association studies (GWASs) is a fundamental problem in human genetics. Although colocalization with gene expression quantitative trait loci (eQTLs) is often used to prioritize GWAS target gene
Externí odkaz:
https://doaj.org/article/563ae9b155174a34a141d7ee3460a524
Autor:
Anette Kalnapenkis, Maarja Jõeloo, Kaido Lepik, Viktorija Kukuškina, Mart Kals, Kaur Alasoo, Estonian Biobank Research Team, Reedik Mägi, Tõnu Esko, Urmo Võsa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The proteome holds great potential as an intermediate layer between the genome and phenome. Previous protein quantitative trait locus studies have focused mainly on describing the effects of common genetic variations on the proteome. Here, w
Externí odkaz:
https://doaj.org/article/ae9bbd01cfa44bda98153108e362f918
Autor:
Siim Kurvits, Ainika Harro, Anu Reigo, Anne Ott, Sven Laur, Dage Särg, Ardi Tampuu, the Estonian Biobank Research Team, Kaur Alasoo, Jaak Vilo, Lili Milani, Toomas Haller, the PRECISE4Q consortium
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-14 (2023)
Abstract Background Ischemic stroke (IS) is a major health risk without generally usable effective measures of primary prevention. Early warning signals that are easy to detect and widely available can save lives. Estonia has one nation-wide Electron
Externí odkaz:
https://doaj.org/article/91b631f5d36245ca9c561eb9c655b94f
Autor:
Nurlan Kerimov, Ralf Tambets, James D Hayhurst, Ida Rahu, Peep Kolberg, Uku Raudvere, Ivan Kuzmin, Anshika Chowdhary, Andreas Vija, Hans J Teras, Masahiro Kanai, Jacob Ulirsch, Mina Ryten, John Hardy, Sebastian Guelfi, Daniah Trabzuni, Sarah Kim-Hellmuth, William Rayner, Hilary Finucane, Hedi Peterson, Abayomi Mosaku, Helen Parkinson, Kaur Alasoo
Publikováno v:
PLoS Genetics, Vol 19, Iss 9, p e1010932 (2023)
The eQTL Catalogue is an open database of uniformly processed human molecular quantitative trait loci (QTLs). We are continuously updating the resource to further increase its utility for interpreting genetic associations with complex traits. Over th
Externí odkaz:
https://doaj.org/article/4747de12cc9a4815a10050170fc3cf70
Autor:
Kaur Alasoo
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100245- (2023)
In this issue of Cell Genomics, Garcia-Perez et al.1 report a comprehensive and careful association analysis between gene expression and splicing measured by the GTEx Consortium2 in 46 human tissues and 21 demographic and clinical traits.
Externí odkaz:
https://doaj.org/article/d49742fdc3b348e79a8c483fbf2826d6
Autor:
James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo, Kaur Alasoo, Kirk A Rockett, Alexander J Mentzer, Dominic P Kwiatkowski, Adrian VS Hill, Kathryn Maitland, J Anthony G Scott, Thomas N Williams
Publikováno v:
eLife, Vol 11 (2022)
Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibili
Externí odkaz:
https://doaj.org/article/5b632ded377f43c8bc16485a42752ec1
Autor:
Lara Bossini-Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail A. Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole, Kaur Alasoo, Alice Mann, Kousik Kundu, Anna Lorenc, Nicole Soranzo, Ian Dunham, David J. Roberts, Gosia Trynka
Publikováno v:
Cell Genomics, Vol 2, Iss 4, Pp 100117- (2022)
Summary: Identifying cellular functions dysregulated by disease-associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. However, follow-up studies can be challenging if disease-relevant cell types are di
Externí odkaz:
https://doaj.org/article/50dd0eba6db04899b2d6d3d94c8d2b92
Publikováno v:
eLife, Vol 9 (2020)
Understanding the causal processes that contribute to disease onset and progression is essential for developing novel therapies. Although trans-acting expression quantitative trait loci (trans-eQTLs) can directly reveal cellular processes modulated b
Externí odkaz:
https://doaj.org/article/7761c0e1c426431faee0c1001ad70b28
Publikováno v:
eLife, Vol 8 (2019)
Genetic variants regulating RNA splicing and transcript usage have been implicated in both common and rare diseases. Although transcript usage quantitative trait loci (tuQTLs) have been mapped across multiple cell types and contexts, it is challengin
Externí odkaz:
https://doaj.org/article/2751f30f15a54b26b8e5447bf343ad5b
Autor:
Christine Hale, Amy Yeung, David Goulding, Derek Pickard, Kaur Alasoo, Fiona Powrie, Gordon Dougan, Subhankar Mukhopadhyay
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124307 (2015)
A number of pathogens, including several human-restricted organisms, persist and replicate within macrophages (Mφs) as a key step in pathogenesis. The mechanisms underpinning such host-restricted intracellular adaptations are poorly understood, in p
Externí odkaz:
https://doaj.org/article/7e913c7deab144ef85ecd457dcbe2002