A study of patients with aggressive multiple sclerosis at disease onset

Autor: Kaunzner UW, Kumar G, Askin G, Gauthier SA, Nealon NN, Vartanian T, Perumal JS

Publikováno v: Neuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1907-1912 (2016)

Ulrike W Kaunzner,1 Gaurav Kumar,2 Gulce Askin,3 Susan A Gauthier,1 Nancy N Nealon,1 Timothy Vartanian,1 Jai S Perumal1 1Judit Jaffe Multiple Sclerosis Center, Weill-Cornell Medical College, New York City, NY, 2Department of Cell Biology and Neurosci

Externí odkaz: https://doaj.org/article/40b89627044949a795a4d190d375434f

Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis.

Autor: Cross AH; Washington University School of Medicine, St Louis, Missouri., Gelfand JM; University of California, San Francisco., Thebault S; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Bennett JL; University of Colorado Anschutz Medical Campus, Aurora., von Büdingen HC; F. Hoffmann-La Roche, Basel, Switzerland., Cameron B; Genentech, South San Francisco, California., Carruthers R; University of British Columbia, Vancouver, British Columbia, Canada., Edwards K; MS Center of Northeastern New York, Latham., Fallis R; The Ohio State University Wexner Medical Center, Columbus., Gerstein R; University of Massachusetts Medical School, Worcester., Giacomini PS; McGill University, Montreal, Quebec, Canada., Greenberg B; The University of Texas Southwestern Medical Center, Dallas., Hafler DA; Yale School of Medicine, New Haven, Connecticut., Ionete C; University of Massachusetts Medical School, Worcester., Kaunzner UW; Weill Cornell Medicine, New York, New York., Kodama L; Genentech, South San Francisco, California., Lock C; Stanford University, Stanford, California., Longbrake EE; Yale School of Medicine, New Haven, Connecticut., Musch B; Genentech, South San Francisco, California., Pardo G; Oklahoma Medical Research Foundation, Oklahoma City., Piehl F; Karolinska Institutet, Solna, Sweden., Weber MS; Institute of Neuropathology, Department of Neurology, University Medical Center, Göttingen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Göttingen, Germany., Yuen S; Genentech, South San Francisco, California., Ziemssen T; Center of Clinical Neuroscience, Carl Gustav Carus University Clinic, Dresden, Germany., Bose G; Department of Medicine in Neurology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Freedman MS; Department of Medicine in Neurology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Anania VG; Genentech, South San Francisco, California., Ramesh A; Genentech, South San Francisco, California., Winger RC; Genentech, South San Francisco, California., Jia X; Genentech, South San Francisco, California., Herman A; Genentech, South San Francisco, California., Harp C; Genentech, South San Francisco, California., Bar-Or A; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Publikováno v: JAMA neurology [JAMA Neurol] 2024 Mar 11. Date of Electronic Publication: 2024 Mar 11.

Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity.

Autor: Shinoda K; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Li R; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Rezk A; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Mexhitaj I; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Patterson KR; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Kakara M; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Zuroff L; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Bennett JL; Departments of Neurology and Ophthalmology, Programs in Neuroscience and Immunology, University of Colorado School of Medicine, Aurora, CO 80045., von Büdingen HC; F. Hoffmann-La Roche, 4070 Basel, Switzerland., Carruthers R; Department of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Edwards KR; Multiple Sclerosis Center of Northeastern New York, Comprehensive MS Care Center Affiliated with the National MS Society, Latham, NY 12110., Fallis R; Department of Neurology, Ohio State University Medical Center, Columbus, OH 43210., Giacomini PS; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Greenberg BM; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Hafler DA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510., Ionete C; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655., Kaunzner UW; Judith Jaffe Multiple Sclerosis Center, Weill Cornell Medicine, New York, NY 10021., Lock CB; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94304., Longbrake EE; Department of Neurology, Yale University, New Haven, CT 06510., Pardo G; Oklahoma Medical Research Foundation, Multiple Sclerosis Center of Excellence, Oklahoma City, OK 73104., Piehl F; Department of Clinical Neuroscience, Karolinska Institute, SE-171 76 Stockholm, Sweden.; Department of Neurology, Karolinska University Hospital, SE-171 77 Stockholm, Sweden.; Neuroimmunology Unit, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, SE-171 77 Stockholm, Sweden., Weber MS; Institute of Neuropathology, University Medical Center, 37075 Göttingen, Germany.; Department of Neurology, University Medical Center, 37075 Göttingen, Germany.; Fraunhofer-Institute for Translational Medicine and Pharmackology ITMP, 37075 Göttingen, Germany., Ziemssen T; Department of Neurology, Center of Clinical Neuroscience, University Hospital Carl Gustav Carus, Technical University of Dresden, 01307 Dresden, Germany., Jacobs D; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Gelfand JM; Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.; Department of Neurology, University of California, San Francisco, CA 94158., Cross AH; Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110., Cameron B; Genentech, Inc., South San Francisco, CA 94080., Musch B; Genentech, Inc., South San Francisco, CA 94080., Winger RC; Genentech, Inc., South San Francisco, CA 94080., Jia X; Genentech, Inc., South San Francisco, CA 94080., Harp CT; Genentech, Inc., South San Francisco, CA 94080., Herman A; Genentech, Inc., South San Francisco, CA 94080., Bar-Or A; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 17; Vol. 120 (3), pp. e2207291120. Date of Electronic Publication: 2023 Jan 12.

Disease correlates of rim lesions on quantitative susceptibility mapping in multiple sclerosis.

Autor: Marcille M; Department of Neurology, Weill Cornell Medicine, New York, NY, USA., Hurtado Rúa S; Department of Mathematics and Statistics, Cleveland State University, Cleveland, OH, USA., Tyshkov C; Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Jaywant A; Department of Psychiatry and Rehabilitation Medicine, Weill Cornell Medicine, New York, NY, USA., Comunale J; Department of Radiology, Weil Cornell Medicine, New York, NY, USA., Kaunzner UW; Department of Neurology, Weill Cornell Medicine, New York, NY, USA., Nealon N; Department of Neurology, Weill Cornell Medicine, New York, NY, USA., Perumal JS; Department of Neurology, Weill Cornell Medicine, New York, NY, USA., Zexter L; Department of Neurology, Weill Cornell Medicine, New York, NY, USA., Zinger N; Department of Neurology, Weill Cornell Medicine, New York, NY, USA., Bruvik O; Department of Neurology, Weill Cornell Medicine, New York, NY, USA., Wang Y; Department of Radiology, Weil Cornell Medicine, New York, NY, USA., Sweeney E; Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA., Kuceyeski A; Department of Radiology, Weil Cornell Medicine, New York, NY, USA.; Feil Family Brain and Mind Institute, Weill Cornell Medicine, New York, NY, USA., Nguyen TD; Department of Radiology, Weil Cornell Medicine, New York, NY, USA., Gauthier SA; Department of Neurology, Weill Cornell Medicine, New York, NY, USA. sag2015@med.cornell.edu.; Department of Radiology, Weil Cornell Medicine, New York, NY, USA. sag2015@med.cornell.edu.; Feil Family Brain and Mind Institute, Weill Cornell Medicine, New York, NY, USA. sag2015@med.cornell.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Mar 15; Vol. 12 (1), pp. 4411. Date of Electronic Publication: 2022 Mar 15.

QSM is an imaging biomarker for chronic glial activation in multiple sclerosis lesions.

Autor: Gillen KM; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Mubarak M; Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA., Park C; Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA., Ponath G; Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA., Zhang S; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Dimov A; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Levine-Ritterman M; Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA., Toro S; Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA., Huang W; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Amici S; Department of Neuroscience, The Ohio State University, Columbus, Ohio, USA., Kaunzner UW; Department of Neurology, Weill Cornell Medicine, New York, New York, USA., Gauthier SA; Department of Radiology, Weill Cornell Medicine, New York, New York, USA.; Department of Neurology, Weill Cornell Medicine, New York, New York, USA., Guerau-de-Arellano M; Department of Neuroscience, The Ohio State University, Columbus, Ohio, USA., Wang Y; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Nguyen TD; Department of Radiology, Weill Cornell Medicine, New York, New York, USA., Pitt D; Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2021 Apr; Vol. 8 (4), pp. 877-886. Date of Electronic Publication: 2021 Mar 11.