Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Kaufman, I A"'
Autor:
Fedorenko, O. A., Kaufman, I. Kh., Gibby, W. A. T., Luchinsky, D. G., Roberts, S. K., McClintock, P. V. E.
A discrete electrostatic/diffusion model has been developed to describe the selective permeation of ion channels, based on ionic Coulomb blockade (ICB) and quantised dehydration (QD). It has been applied to describe selectivity phenomena measured in
Externí odkaz:
http://arxiv.org/abs/1803.07063
Ionic Coulomb blockade (ICB) is an electrostatic phenomenon recently discovered in low-capacitance ion channels/nanopores. Depending on the fixed charge that is present, ICB strongly and selectively influences the ease with which a given type of ion
Externí odkaz:
http://arxiv.org/abs/1704.00956
Autor:
Kaufman, I. Kh., Fedorenko, O. A., Luchinsky, D. G., Gibby, W. A. T., McClintock, S. K. Roberts. P. V. E., Eisenberg, R. S.
We report an experimental study of the influences of the fixed charge and bulk ionic concentrations on the conduction of biological ion channels, and we consider the results within the framework of the ionic Coulomb blockade model of permeation and s
Externí odkaz:
http://arxiv.org/abs/1612.02744
We present an equilibrium statistical-mechanical theory of selectivity in biological ion channels. In doing so, we introduce a grand canonical ensemble for ions in a channel's selectivity filter coupled to internal and external bath solutions for a m
Externí odkaz:
http://arxiv.org/abs/1604.05758
The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb blockade, a phenomenon based on charge discreteness and an electrostatic model of an ion channel. This novel approach provides a unified explanation
Externí odkaz:
http://arxiv.org/abs/1405.1391
Publikováno v:
Phys. Rev. E 88, 052712 (2013)
We use Brownian dynamics simulations to study the permeation properties of a generic electrostatic model of a biological ion channel as a function of the fixed charge $Q_f$ at its selectivity filter. We reconcile the recently-discovered discrete calc
Externí odkaz:
http://arxiv.org/abs/1305.1847
Publikováno v:
Phys. Biol. 10 (2013) 026007
We report self-consistent Brownian dynamics simulations of a simple electrostatic model of the selectivity filters (SF) of calcium ion channels. They reveal regular structure in the conductance and selectivity as functions of the fixed negative charg
Externí odkaz:
http://arxiv.org/abs/1209.2381
The effect of fluctuations on the conductivity of ion channels is investigated. It is shown that modulation of the potential barrier at the selectivity site due to electrostatic amplification of charge fluctuations at the channel mouth exerts a leadi
Externí odkaz:
http://arxiv.org/abs/0807.0838
Electrostatic interaction between ions in an ionic channel and the charge fluctuations in the channel mouth are considered. It is shown that the charge fluctuations can be enhanced in the channels with low dielectric constant and result in strong mod
Externí odkaz:
http://arxiv.org/abs/physics/0611240
Autor:
Kaufman, I. Charles
Publikováno v:
Ethos, 1975 Jul 01. 3(2), 129-142.
Externí odkaz:
https://www.jstor.org/stable/640224
