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of 3
pro vyhledávání: '"Kauffman, Kevin John"'
Autor:
Kauffman, Kevin John
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 153-167).
Messenger RNA (mRNA) therapeutics have the pote
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 153-167).
Messenger RNA (mRNA) therapeutics have the pote
Externí odkaz:
http://hdl.handle.net/1721.1/111408
Autor:
Mark W. Tibbitt, Rebecca L. McClellan, J. Robert Dorkin, Robert Langer, Frank Derosa, Owen S. Fenton, Eric A. Appel, Kevin J. Kauffman, Daniel G. Anderson, Michael W. Heartlein
Publikováno v:
PMC
Thousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs) capable of delivering human mRNA with unprecedented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78db00e9cf5b93e509e9da82b60234a0
https://doi.org/10.1002/adma.201505822
https://doi.org/10.1002/adma.201505822
Autor:
Kevin J. Kauffman, Michael W. Heartlein, Daniel G. Anderson, Matthew J. Webber, Piotr S. Kowalski, Juan E. Hurtado, Frank Derosa, Siddharth Jhunjhunwala, James C. Kaczmarek, Faryal F. Mir, Jung H. Yang
Publikováno v:
PMC
Biomaterials
Biomaterials
mRNA has broad potential for treating diseases requiring protein expression. However, mRNA can also induce an immune response with associated toxicity. Replacement of uridine bases with pseudouridine has been postulated to modulate both mRNA immunoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b4d19a6dc58fef82e7e3d70552777a
https://orcid.org/0000-0001-8046-2288
https://orcid.org/0000-0001-8046-2288