Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

Autor: Renner, Kathrin, Bruss, Christina, Schnell, Annette, Koehl, Gudrun, Becker, Holger M., Fante, Matthias, Menevse, Ayse-Nur, Kauer, Nathalie, Blazquez, Raquel, Hacker, Lisa, Decking, Sonja-Maria, Bohn, Toszka, Faerber, Stephanie, Evert, Katja, Aigle, Lisa, Amslinger, Sabine, Landa, Maria, Krijgsman, Oscar, Rozeman, Elisa A., Brummer, Christina, Siska, Peter J., Singer, Katrin, Pektor, Stefanie, Miederer, Matthias, Peter, Katrin, Gottfried, Eva, Herr, Wolfgang, Marchiq, Ibtisam, Pouyssegur, Jacques, Roush, William R., Ong, SuFey, Warren, Sarah, Pukrop, Tobias, Beckhove, Philipp, Lang, Sven A., Bopp, Tobias, Blank, Christian U., Cleveland, John L., Oefner, Peter J., Dettmer, Katja, Selby, Mark, Kreutz, Marina

Publikováno v: Cell Reports, Vol 29, Iss 1, Pp 135-150.e9 (2019)

Summary: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b511765eba4e6d832d42b6f1644fbc
https://epub.uni-regensburg.de/40812/

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.

Autor: Renner K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Regensburg Center for Interventional Immunology, Regensburg, Germany. Electronic address: kathrin.renner-sattler@ukr.de., Bruss C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Schnell A; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Koehl G; Department of Surgery, University Hospital Regensburg, Regensburg, Germany., Becker HM; Division of General Zoology, University of Kaiserslautern, Kaiserslautern, Germany., Fante M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Menevse AN; Regensburg Center for Interventional Immunology, Regensburg, Germany., Kauer N; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Blazquez R; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Hacker L; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Decking SM; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Bohn T; Institute for Immunology, University Medical Center Johannes Gutenberg University (UMC) Mainz, Mainz, Germany., Faerber S; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Evert K; Institute of Pathology, University of Regensburg, Regensburg, Germany., Aigle L; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Amslinger S; Institute of Organic Chemistry, University of Regensburg, Regensburg, Germany., Landa M; Institute of Organic Chemistry, University of Regensburg, Regensburg, Germany., Krijgsman O; Department Medical Oncology and Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Rozeman EA; Department Medical Oncology and Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Brummer C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Siska PJ; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Singer K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Pektor S; Department of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Miederer M; Department of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Peter K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Gottfried E; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Herr W; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Marchiq I; Institute of Research on Cancer and Aging (IRCAN), CNRS-INSERM-UNS UMR 7284, Nice, France., Pouyssegur J; Institute of Research on Cancer and Aging (IRCAN), CNRS-INSERM-UNS UMR 7284, Nice, France; Department of Medical Biology, Scientific Centre of Monaco (CSM), Monaco., Roush WR; Department of Chemistry, The Scripps Research Institute, Scripps-Florida, Jupiter, FL, USA., Ong S; NanoString Technologies, Seattle, WA, USA., Warren S; NanoString Technologies, Seattle, WA, USA., Pukrop T; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Beckhove P; Regensburg Center for Interventional Immunology, Regensburg, Germany., Lang SA; Department of General and Visceral Surgery, Medical Center, Faculty of Medicine University of Freiburg, Freiburg, Germany., Bopp T; Institute for Immunology, University Medical Center Johannes Gutenberg University (UMC) Mainz, Mainz, Germany; Research Center for Immunotherapy (FZI), UMC Mainz, Mainz, Germany; University Cancer Center Mainz, UMC Mainz, Mainz, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany., Blank CU; Department Medical Oncology and Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Cleveland JL; Department of Tumor Biology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Oefner PJ; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Selby M; Bristol-Myers Squibb, Redwood City, CA, USA., Kreutz M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Regensburg Center for Interventional Immunology, Regensburg, Germany.

Publikováno v: Cell reports [Cell Rep] 2019 Oct 01; Vol. 29 (1), pp. 135-150.e9.