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Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα.

Autor: Sim J; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Sockolosky JT; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Sangalang E; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Izquierdo S; b Ligand Pharmaceuticals, Inc , Emeryville , CA , USA., Pedersen D; b Ligand Pharmaceuticals, Inc , Emeryville , CA , USA., Harriman W; b Ligand Pharmaceuticals, Inc , Emeryville , CA , USA., Wibowo AS; c Helix Biostructures , Columbus , IN , USA., Carter J; c Helix Biostructures , Columbus , IN , USA., Madan A; d Covance Genomics Laboratory , Redmond , WA , USA., Doyle L; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Harrabi O; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Kauder SE; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Chen A; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Kuo TC; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Wan H; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA., Pons J; a ALX Oncology, Departments of Protein Sciences and Translational Biology , Burlingame , CA , USA.

Publikováno v: MAbs [MAbs] 2019 Aug/Sep; Vol. 11 (6), pp. 1036-1052. Date of Electronic Publication: 2019 Jul 01.

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.

Autor: DePianto DJ; Genentech Research and Early Development, South San Francisco, California, USA., Chandriani S; Genentech Research and Early Development, South San Francisco, California, USA Novartis Institutes for Biomedical Research, Emeryville, California, USA., Abbas AR; Genentech Research and Early Development, South San Francisco, California, USA., Jia G; Genentech Research and Early Development, South San Francisco, California, USA., N'Diaye EN; Genentech Research and Early Development, South San Francisco, California, USA., Caplazi P; Genentech Research and Early Development, South San Francisco, California, USA., Kauder SE; Genentech Research and Early Development, South San Francisco, California, USA., Biswas S; Genentech Research and Early Development, South San Francisco, California, USA., Karnik SK; Genentech Research and Early Development, South San Francisco, California, USA Gilead Sciences, Foster City, California, USA., Ha C; Genentech Research and Early Development, South San Francisco, California, USA., Modrusan Z; Genentech Research and Early Development, South San Francisco, California, USA., Matthay MA; Department of Medicine, University of California, San Francisco, California, USA., Kukreja J; Department of Surgery, University of California, San Francisco, California, USA., Collard HR; Department of Medicine, University of California, San Francisco, California, USA., Egen JG; Genentech Research and Early Development, South San Francisco, California, USA., Wolters PJ; Department of Medicine, University of California, San Francisco, California, USA., Arron JR; Genentech Research and Early Development, South San Francisco, California, USA.

Publikováno v: Thorax [Thorax] 2015 Jan; Vol. 70 (1), pp. 48-56. Date of Electronic Publication: 2014 Sep 12.

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

Autor: Kauder SE; Discovery Immunology, Genentech Inc., South San Francisco, California, United States of America., Santell L; Early Discovery Biochemistry, Genentech Inc., South San Francisco, California, United States of America., Mai E; Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America., Wright LY; Immunology, Tissue Growth and Repair- Diagnostics Discovery, Genentech Inc., South San Francisco, California, United States of America., Luis E; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., N'Diaye EN; Discovery Immunology, Genentech Inc., South San Francisco, California, United States of America., Lutman J; Pharmacokinetics and Pharmacodynamics, Genentech Inc., South San Francisco, California, United States of America., Ratti N; Pathology, Genentech Inc., South San Francisco, California, United States of America., Sa SM; Pathology, Genentech Inc., South San Francisco, California, United States of America., Maun HR; Early Discovery Biochemistry, Genentech Inc., South San Francisco, California, United States of America., Stefanich E; Pharmacokinetics and Pharmacodynamics, Genentech Inc., South San Francisco, California, United States of America., Gonzalez LC; Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America., Graham RR; Immunology, Tissue Growth and Repair -Human Genetics, Genentech Inc., South San Francisco, California, United States of America., Diehl L; Pathology, Genentech Inc., South San Francisco, California, United States of America., Faubion WA Jr; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America., Keir ME; Immunology, Tissue Growth and Repair- Diagnostics Discovery, Genentech Inc., South San Francisco, California, United States of America., Young J; Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America., Chaudhuri A; Molecular Oncology, Genentech Inc., South San Francisco, California, United States of America., Lazarus RA; Early Discovery Biochemistry, Genentech Inc., South San Francisco, California, United States of America., Egen JG; Discovery Immunology, Genentech Inc., South San Francisco, California, United States of America.

Publikováno v: PloS one [PLoS One] 2013 Dec 23; Vol. 8 (12), pp. e83958. Date of Electronic Publication: 2013 Dec 23 (Print Publication: 2013).

Epigenetic regulation of HIV-1 latency by cytosine methylation.

Autor: Kauder SE; Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America., Bosque A, Lindqvist A, Planelles V, Verdin E

Publikováno v: PLoS pathogens [PLoS Pathog] 2009 Jun; Vol. 5 (6), pp. e1000495. Date of Electronic Publication: 2009 Jun 26.