Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katya Marjon"'
Autor:
Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, met
Externí odkaz:
https://doaj.org/article/bd77de65b22f4da89618bc5269d7f141
Autor:
Joshua Murtie, Anil K. Padyana, Lei Jin, Marc L. Hyer, Zhixiao Liu, Scott A. Biller, Jeremy Travins, Amelia Barnett, Katya Marjon, Brandon Nicolay, Wentao Wei, Raj Nagaraja, Cheng Fang, Yi Gao, Yabo Sun, Ye Zhixiong, Fan Jiang, Peter Kalev, Stefan Gross, Zenon D. Konteatis, Byron DeLaBarre, Zhihua Sui, Kevin Marks, Lenny Dang, Jie Yu, Everton Mandley, Yue Chen
Publikováno v:
Journal of Medicinal Chemistry. 64:4430-4449
The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97283e129d6853ac6b9ff735db2724ec
https://doi.org/10.1021/acs.jmedchem.0c01895
https://doi.org/10.1021/acs.jmedchem.0c01895
Publikováno v:
Annual Review of Cancer Biology. 5:371-390
Discovery of targeted therapies that selectively exploit the genetic inactivation of specific tumor suppressors remains a major challenge. This includes the prevalent deletion of the CDKN2A/ MTAP locus, which was first reported nearly 40 years ago. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd01ab3fd5500ea60746e234f52b2b6
https://doi.org/10.1146/annurev-cancerbio-030419-033444
https://doi.org/10.1146/annurev-cancerbio-030419-033444
Autor:
Navyateja Korimerla, Kari-Wilder Romans, Peter Kalev, Ayesha Kothari, Nathan Qi, Charles Evans, Maureen Kachman, Marc L Hyer, Katya Marjon, Taryn Sleger, Daniel R Wahl
Publikováno v:
Cancer Research. 83:1095-1095
Glioblastoma (GBM) is the most aggressive adult brain tumor and is uniformly fatal due to resistance to standard therapies such as radiation (RT) and chemotherapy. Our group and others have identified altered metabolism as a key mediator of GBM RT re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60769b881d8f091a441274416102d0b0
https://doi.org/10.1158/1538-7445.am2023-1095
https://doi.org/10.1158/1538-7445.am2023-1095
Autor:
Mingzong Li, Zenon Konteatis, Nelamangala Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Gross, Katya Marjon, Marc L. Hyer, Everton Mandley, Max Lein, Anil K. Padyana, Lei Jin, Shuilong Tong, Rachel Peters, Joshua Murtie, Jeremy Travins, Matthew Medeiros, Peng Liu, Victoria Frank, Evan T. Judd, Scott A. Biller, Kevin M. Marks, Zhihua Sui, Samuel K. Reznik
Publikováno v:
Journal of medicinal chemistry. 65(6)
Inhibition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd4665a566b3b92c2d5c0229953dea0
https://pubmed.ncbi.nlm.nih.gov/35293760
https://pubmed.ncbi.nlm.nih.gov/35293760
Autor:
Zenon, Konteatis, Jeremy, Travins, Stefan, Gross, Katya, Marjon, Amelia, Barnett, Everton, Mandley, Brandon, Nicolay, Raj, Nagaraja, Yue, Chen, Yabo, Sun, Zhixiao, Liu, Jie, Yu, Zhixiong, Ye, Fan, Jiang, Wentao, Wei, Cheng, Fang, Yi, Gao, Peter, Kalev, Marc L, Hyer, Byron, DeLaBarre, Lei, Jin, Anil K, Padyana, Lenny, Dang, Joshua, Murtie, Scott A, Biller, Zhihua, Sui, Kevin M, Marks
Publikováno v:
Journal of medicinal chemistry. 64(8)
The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ec9204e0504cb32589dbe975f9a1cd3
https://pubmed.ncbi.nlm.nih.gov/33829783
https://pubmed.ncbi.nlm.nih.gov/33829783
Autor:
Rachel Peters, Kate Lizotte, Victoria Frank, Yesim Tuncay, Katie Sellers, Elia Aguado-Fraile, Marc L. Hyer, Everton Mandley, Scott A. Biller, Michelle Clasquin, Katya Marjon, Phong Quang, Jeremy Travins, Joshua E. Goldford, Zenon D. Konteatis, Chi-Chao Chen, Jaclyn Weier, Lenny Dang, Raj Nagaraja, Peter Kalev, Kevin Marks, Wei Liu, Eric Simone, Joshua Murtie, Stefan Gross, Max Lein, Yue Chen, Mark Fletcher, Amelia Barnett, Zhihua Sui, Sebastian Hayes
Publikováno v:
Cancer Cell. 39:209-224.e11
The methylthioadenosine phosphorylase (MTAP) gene is located adjacent to the cyclin-dependent kinase inhibitor 2A (CDKN2A) tumor-suppressor gene and is co-deleted with CDKN2A in approximately 15% of all cancers. This co-deletion leads to aggressive t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321c4d9d9fb5c7eb5dbd4d4870244aa
https://doi.org/10.1016/j.ccell.2020.12.010
https://doi.org/10.1016/j.ccell.2020.12.010
Autor:
Scott A. Biller, Michelle L. Blake, Joshua Murtie, Everton Mandley, Kevin Marks, Zenon D. Konteatis, Andrew Kernytsky, Michael J. Cameron, Sung Choe, Marion Dorsch, Jeremy Travins, Kaiko Kunii, Stefan Gross, Michelle Clasquin, Katya Marjon, Phong Quang, Michael McVay
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)
SummaryHomozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d93cf9f3be5f9e6d72b655d54b22f8
Autor:
Elia Aguado-Fraile, Sheila Newhouse, Mark Fletcher, Chi-Chao Chen, Marc L. Hyer, Katya Marjon, Raj Nagaraja, Max Lein, Yesim Tuncay, Josh Murtie, Everton Mandley, Kevin Marks, Peter Kalev
Publikováno v:
Cancer Research. 80:3090-3090
MAT2A (methionine adenosyltransferase 2 alpha) is a critical enzyme within the methionine salvage pathway responsible for generating the universal methyl group donor, S-adenosyl methionine (SAM). We have developed a first-in-class small molecule inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8677b9f70676367f07acf17c0751d197
https://doi.org/10.1158/1538-7445.am2020-3090
https://doi.org/10.1158/1538-7445.am2020-3090
Autor:
Kevin Marks, Peili Zhang, Katya Marjon, Zenon D. Konteatis, Yesim Tuncay, Mark Fletcher, Marc L. Hyer, Everton Mandley, Jeremy Travins, Peter Kalev, Elia Aguado-Fraile
Publikováno v:
Molecular Cancer Therapeutics. 18:B115-B115
Methylthioadenosine phosphorylase (MTAP) is the enzyme in the methionine salvage pathway that metabolizes the byproduct of polyamine biosynthesis, 5′-methylthioadenosine (MTA). The MTAP gene is deleted in approximately 15% of all human cancers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c85c390cce55ab0a34b59664e023da4c
https://doi.org/10.1158/1535-7163.targ-19-b115
https://doi.org/10.1158/1535-7163.targ-19-b115