Výsledky vyhledávání - "Katya, Marjon"

Akademický článek

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

Autor: Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks

Publikováno v: Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)

Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, met

Externí odkaz: https://doaj.org/article/bd77de65b22f4da89618bc5269d7f141

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Abstract 1095: Exploiting altered methionine metabolism to overcome treatment resistance in glioblastoma

Autor: Navyateja Korimerla, Kari-Wilder Romans, Peter Kalev, Ayesha Kothari, Nathan Qi, Charles Evans, Maureen Kachman, Marc L Hyer, Katya Marjon, Taryn Sleger, Daniel R Wahl

Publikováno v: Cancer Research. 83:1095-1095

Glioblastoma (GBM) is the most aggressive adult brain tumor and is uniformly fatal due to resistance to standard therapies such as radiation (RT) and chemotherapy. Our group and others have identified altered metabolism as a key mediator of GBM RT re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60769b881d8f091a441274416102d0b0
https://doi.org/10.1158/1538-7445.am2023-1095

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Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

Publikováno v: Journal of Medicinal Chemistry. 64:4430-4449

The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97283e129d6853ac6b9ff735db2724ec
https://doi.org/10.1021/acs.jmedchem.0c01895

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Cancer Dependencies: PRMT5 and MAT2A in MTAP/p16-Deleted Cancers

Autor: Peter Kalev, Katya Marjon, Kevin Marks

Publikováno v: Annual Review of Cancer Biology. 5:371-390

Discovery of targeted therapies that selectively exploit the genetic inactivation of specific tumor suppressors remains a major challenge. This includes the prevalent deletion of the CDKN2A/ MTAP locus, which was first reported nearly 40 years ago. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffd01ab3fd5500ea60746e234f52b2b6
https://doi.org/10.1146/annurev-cancerbio-030419-033444

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Abstract 3090: The MAT2A inhibitor, AG-270, combines with both taxanes and gemcitabine to yield enhanced anti-tumor activity in patient-derived xenograft models

Autor: Elia Aguado-Fraile, Sheila Newhouse, Mark Fletcher, Chi-Chao Chen, Marc L. Hyer, Katya Marjon, Raj Nagaraja, Max Lein, Yesim Tuncay, Josh Murtie, Everton Mandley, Kevin Marks, Peter Kalev

Publikováno v: Cancer Research. 80:3090-3090

MAT2A (methionine adenosyltransferase 2 alpha) is a critical enzyme within the methionine salvage pathway responsible for generating the universal methyl group donor, S-adenosyl methionine (SAM). We have developed a first-in-class small molecule inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8677b9f70676367f07acf17c0751d197
https://doi.org/10.1158/1538-7445.am2020-3090

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Abstract B115: Mitotic defects induced by MAT2A inhibitors guides translational drug combination strategies with AG-270 and taxanes

Autor: Kevin Marks, Peili Zhang, Katya Marjon, Zenon D. Konteatis, Yesim Tuncay, Mark Fletcher, Marc L. Hyer, Everton Mandley, Jeremy Travins, Peter Kalev, Elia Aguado-Fraile

Publikováno v: Molecular Cancer Therapeutics. 18:B115-B115

Methylthioadenosine phosphorylase (MTAP) is the enzyme in the methionine salvage pathway that metabolizes the byproduct of polyamine biosynthesis, 5′-methylthioadenosine (MTA). The MTAP gene is deleted in approximately 15% of all human cancers and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c85c390cce55ab0a34b59664e023da4c
https://doi.org/10.1158/1535-7163.targ-19-b115

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MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

Autor: Scott A. Biller, Michelle L. Blake, Joshua Murtie, Everton Mandley, Kevin Marks, Zenon D. Konteatis, Andrew Kernytsky, Michael J. Cameron, Sung Choe, Marion Dorsch, Jeremy Travins, Kaiko Kunii, Stefan Gross, Michelle Clasquin, Katya Marjon, Phong Quang, Michael McVay

Publikováno v: Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)

SummaryHomozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d93cf9f3be5f9e6d72b655d54b22f8

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