Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Katy Van Kirk"'
Autor:
William J. Pitts, Alaric J. Dyckman, Scott H. Watterson, Robert V. Moquin, Kim W. McIntyre, Zheng Yang, Jagabandhu Das, Katy Van Kirk, James R. Burke, David B. Wang-Iverson, Hollie Booth-Lute, James Kempson, Laishun Chen, Charles M. Langevine, Joel C. Barrish, Guchen Yang, Xiaoxia Yang, John H. Dodd, David S. Nirschl, Murray McKinnon, Steven H. Spergel, Mark A. Pattoli, Michael Galella, Kurt R. Gregor, Junquing Guo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7006-7012
The synthesis, structure-activity relationships (SAR), and biological results of pyridyl-substituted azaindole based tricyclic inhibitors of IKK2 are described. Compound 4m demonstrated potent in vitro potency, acceptable pharmacokinetic and physicoc
Autor:
Charles M. Langevine, Joseph A. Furch, Dominique Belanger, Mark A. Pattoli, Joel C. Barrish, Alaric J. Dyckman, Marco Dodier, James Kempson, Jagabandhu Das, David S. Nirschl, Laishun Chen, Punit Marathe, Kathleen M. Gillooly, Junqing Guo, Robert V. Moquin, John H. Dodd, Murray McKinnon, Anne Marinier, Zheng Yang, Steven H. Spergel, Claude A. Quesnelle, Kim W. McIntyre, Katy Van Kirk, James R. Burke, William J. Pitts, Scott H. Watterson, Alain Martel, Patrice Gill, David B. Wang-Iverson, Tianle Li
Publikováno v:
Journal of Medicinal Chemistry. 52:1994-2005
The design and synthesis of a novel series of oxazole-, thiazole-, and imidazole-based inhibitors of IkappaB kinase (IKK) are reported. Biological activity was improved compared to the pyrazolopurine lead, and the expedient synthesis of the new tricy
Autor:
Jacques Y. Roberge, Muthoni G. Kamau, Sam T. Chao, Arvind Mathur, Michael A. Poss, Zheming Ruan, Lalgudi S. Harikrishnan, Dora M. Schnur, Mark S. Bednarz, John K. Dickson, Roy J. Vaz, Yalei Liu, R. Michael Lawrence, Ramesh Kakarla, Leslie Leith, Ashvinikumar V. Gavai, Christopher B. Cooper, Katy Van Kirk
Publikováno v:
Journal of Combinatorial Chemistry. 11:72-82
A G-Protein-coupled receptor-targeted library of aryloxypropanolamines and aryloxybutanolamines was efficiently executed using a novel, polymer-supported acyclic acetal linker, producing compounds in good yields and purities.
Publikováno v:
Research Letters in Organic Chemistry. 2008:1-4
The direct conversion of solid-supported carboxylic acid allyl esters to carboxamides through the use of phenylsilane and catalytic Pd under mild reaction conditions is reported. The use of this methodology for the generation of a 48 compound solid-p
Autor:
Heather Finlay, Mark E. Salvati, Leonard P. Adam, Ji Jiang, Ruth R. Wexler, Christine Huang, David S. Taylor, Xiaohong Yin, Alice Ye A. Chen, Paul G. Sleph, Yufeng Wang, Muthoni G. Kamau, Wu Yang, R. Michael Lawrence, David S. Nirschl, Lalgudi S. Harikrishnan, Katy Van Kirk, Richard Yang
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(3)
A series of diphenylpyridylethanamine-based inhibitors of cholesteryl ester transfer protein with aminoheterocycles appended onto the N-terminus of the chemotype were explored as urea mimetics. Potent compounds were discovered and were further optimi
Publikováno v:
Solid-Phase Organic Syntheses, Volume 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82fa37a53732461dd878613c2bea2594
https://doi.org/10.1002/9781118336953.ch3
https://doi.org/10.1002/9781118336953.ch3
Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors
Autor:
Leonard P. Adam, Michael A. Poss, Mark E. Salvati, James J. Li, Muthoni G. Kamau, R. Michael Lawrence, Michael Galella, Heather Finlay, Xue-Qing Chen, Arthur V. Miller, Richard Yang, Tammy C. Wang, Doree F. Sitkoff, Xiaohong Yin, Alice Ye A. Chen, Christine Huang, David S. Taylor, Lalgudi S. Harikrishnan, Paul G. Sleph, Ji Jiang, Christopher B. Cooper, Ruth R. Wexler, David S. Nirschl, Ming Chang, Katy Van Kirk, Jennifer X. Qiao
Publikováno v:
Journal of medicinal chemistry. 55(13)
A series of diphenylpyridylethanamine (DPPE) derivatives was identified exhibiting potent CETP inhibition. Replacing the labile ester functionality in the initial lead 7 generated a series of amides and ureas. Further optimization of the DPPE series
Autor:
Christopher B. Cooper, Wu Yang, John K. Dickson, Ramakrishna Seethala, Jean H.M. Feyen, Katy Van Kirk, Yufeng Wang, Zhengping Ma, Zheming Ruan, Brian J. Arey
Publikováno v:
Journal of medicinal chemistry. 52(4)
The trisubstituted pyrimidine 1 was identified through high-throughput screening as a novel calcium-sensing receptor (CaSR) antagonist. Small molecule CaSR antagonists and/or negative allosteric modulators have the potential to act as an anabolic age
Autor:
David S. Nirschl, Stanley R. Krystek, James C. Sutton, Daniel M. Camac, Ramakrishna Seethala, Jeffrey A. Robl, Rajasree Golla, James J. Li, Robert Zahler, Paul E. Morin, Haixia Wang, Rebecca A. Smirk, Cooper Christopher B, Mary Ellen K. Salyan, Katy Van Kirk, Zhengping Ma, Steven Sheriff, David A. Gordon, Ligaya M. Simpkins, Zheming Ruan, Robert D. Hutchins, Brian Carpenter, Akbar Nayeem, Lawrence G. Hamann, Shung C. Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(11)
Several series of pyridine amides were identified as selective and potent 11beta-HSD1 inhibitors. The most potent inhibitors feature 2,6- or 3,5-disubstitution on the pyridine core. Various linkers (CH(2)SO(2), CH(2)S, CH(2)O, S, O, N, bond) between
Autor:
Cooper Christopher B, Michael A. Poss, Zheming Ruan, Muthoni G. Kamau, Dharmpal S. Dodd, Mark A. Hermsmeier, Katy Van Kirk, Rogelio L. Martinez, and Sarah C. Traeger
Publikováno v:
Journal of combinatorial chemistry. 7(4)
An efficient method for the solid-supported synthesis of 5-N-alkylamino and 5-N-arylamino pyrazoles is described. This method is general and mild and utilizes readily accessible resin-immobilized beta-ketoamides 2 as starting materials for the prepar