Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Katy M Roach"'
Autor:
Greer K Arthur, S Mark Duffy, Katy M Roach, Rob A Hirst, Aarti Shikotra, Erol A Gaillard, Peter Bradding
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145259 (2015)
The KCa3.1 K+ channel has been proposed as a novel target for pulmonary diseases such as asthma and pulmonary fibrosis. It is expressed in epithelia but its expression and function in primary human bronchial epithelial cells (HBECs) has not been desc
Externí odkaz:
https://doaj.org/article/d011514bda36493d8f752a9b4f094f43
Autor:
Katy M Roach, Stephen Mark Duffy, William Coward, Carol Feghali-Bostwick, Heike Wulff, Peter Bradding
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/95cdb67aa7624477a8a9bee9911958bf
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61579 (2013)
Mast cells (MCs) play a central role in the development of many diseases including asthma and pulmonary fibrosis. Interactions of human lung mast cells (HLMCs) with human airway smooth muscle cells (HASMCs) are partially dependent on adhesion mediate
Externí odkaz:
https://doaj.org/article/6ccd4c53224c4fe582deb82ee88ea85e
Autor:
Katy M Roach, Stephen Mark Duffy, William Coward, Carol Feghali-Bostwick, Heike Wulff, Peter Bradding
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85244 (2013)
Idiopathic pulmonary fibrosis (IPF) is a common, progressive and invariably lethal interstitial lung disease with no effective therapy. We hypothesised that K(Ca)3.1 K(+) channel-dependent cell processes contribute to IPF pathophysiology.K(Ca)3.1 exp
Externí odkaz:
https://doaj.org/article/1b7dcc61219f46a0abb784ed77df36e8
Autor:
Abdulrahman Alzahrani, Jameel Hakeem, Michael Biddle, Fahad Alhadian, Aamir Hussain, Latifa Khalfaoui, Katy M. Roach, Omar Tliba, Peter Bradding, Yassine Amrani
Publikováno v:
Frontiers in Allergy, Vol 2 (2021)
The mechanisms underlying corticosteroid insensitivity in severe asthma have not been elucidated although some indirect clinical evidence points toward a role of mast cells. Here, we tested the hypothesis that mast cells can drive corticosteroid inse
Externí odkaz:
https://doaj.org/article/2d6cc5806c3343ea905d61faa697cb69
Autor:
Katy M. Roach, Amanda Sutcliffe, Laura Matthews, Gill Elliott, Chris Newby, Yassine Amrani, Peter Bradding
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. KCa3.1 ion channels play a critical role in TGFβ1-dependent pro-fibrotic responses in human lung myofibroblasts. We aimed to de
Externí odkaz:
https://doaj.org/article/46976a4f4c0e44a38515a896ef024507
Autor:
Panayiota Stylianou, Sara Rushwan, Wei Wang, M. Azim Miah, Omeed Darweesh, Alison Mackinnon, Katy M. Roach, Charles J. Hitchman, Oksana Gonchar, Stephen Thorpe, Christopher Harris, Richard Haigh, David F Richards, Vladimir Snetkov, Jessica Beasley, Simon J Cleary, Michael Barer, Jeremy PT Ward, Claire Rooney, Frank McCaughan, Peter Bradding, Richard Beale, Martin M Knight, Tariq Sethi, Bibek Gooptu
Progressive fibrosing interstitial lung diseases (PFILDs) cause substantial morbidity and mortality. Antifibrotic agents slow progression, but most of the clinical need remains unmet. The archetypal PFILD is idiopathic pulmonary fibrosis (IPF). Chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b568ca7e857cd76f330eebd8bd7b1726
https://doi.org/10.1101/2022.08.12.503154
https://doi.org/10.1101/2022.08.12.503154
Autor:
Michael Biddle, Dawn T. Smallwood, E Castells, Peter Bradding, Katy M. Roach, Cathryn Weston, Yassine Amrani, Viona W. Bowman, Harvinder Virk, Jamie McCarthy, S. Mark Duffy
Publikováno v:
British Journal of Pharmacology. 178:2948-2962
BACKGROUND AND PURPOSE TGFβ1-mediated myofibroblast activation contributes to pathological fibrosis in many diseases including idiopathic pulmonary fibrosis (IPF), where myofibroblast resistance to oxidant-mediated apoptosis is also evident. We ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0db6341e9b5fd4c470815fca25d68c
https://doi.org/10.1111/bph.15467
https://doi.org/10.1111/bph.15467
Autor:
Katy M. Roach, Peter Bradding
Publikováno v:
British Journal of Pharmacology. 177:1003-1024
The role of Ca2+ signalling in fibroblasts is of great interest in fibrosis-related diseases. Intracellular free Ca2+ ([Ca2+ ]i ) is a ubiquitous secondary messenger, regulating a number of cellular functions such as secretion, metabolism, differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51377dca3fbf38f0d6eacef165cb187f
https://doi.org/10.1111/bph.14939
https://doi.org/10.1111/bph.14939
Autor:
Peter Bradding, Yassine Amrani, Christopher E. Brightling, Katherine Clark, Katy M. Roach, Panayiota Stylianou, Dawn T. Smallwood, Bibek Gooptu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Chronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in the TNS1 gene, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769dcfd915720b8cb8604435405b608d
https://doi.org/10.1038/s41598-019-55405-2
https://doi.org/10.1038/s41598-019-55405-2