Multi-arm multi-stage clinical trials for time-to-event outcomes

Autor: Katy L. Simonsen, Priyam Mitra, Vaidehi Dixit

Publikováno v: Journal of biopharmaceutical statistics. 31(6)

This paper investigates the use of a general multi-arm multi-stage (MAMS) approach for time-to-event outcomes that would streamline simultaneous comparison of a large number of promising therapies in clinical trials, thus significantly reducing the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f3bf23138da21b5ab739570ed8c4e2
https://pubmed.ncbi.nlm.nih.gov/34606418

The Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) program: innovative, high-throughput clinical screening of immunotherapies

Autor: Katy L. Simonsen, Adriana Comprelli, Paula M. Fracasso, Steven H. Bernstein, Cassidy James, Timothy P. Reilly, Megan Wind-Rotolo, Manish Gupta

Publikováno v: European journal of cancer (Oxford, England : 1990). 103

Background The unprecedented success of immuno-oncology (I-O) agents targeting the cytotoxic T lymphocyte–associated antigen 4 and programmed death-1/programmed death-ligand 1 pathways has stimulated the rapid development of other I-O agents agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4112f0194b37face49d3b95e14ee069
https://pubmed.ncbi.nlm.nih.gov/30292142

Effects ofCYP2C19Genotype on Outcomes of Clopidogrel Treatment

Autor: Jack Hirsh, Stuart J. Connolly, Katy L. Simonsen, Sonia S. Anand, Guillaume Paré, Deepak L. Bhatt, Keith A.A. Fox, Salim Yusuf, Shamir R. Mehta, John W. Eikelboom

Publikováno v: Paré, G, Mehta, S R, Yusuf, S, Anand, S S, Connolly, S J, Hirsh, J, Simonsen, K, Bhatt, D L, Fox, K A A & Eikelboom, J W 2010, ' Effects of CYP2C19 genotype on outcomes of clopidogrel treatment ', New England Journal of Medicine, vol. 363, no. 18, pp. 1704-14 . https://doi.org/10.1056/NEJMoa1008410

It has been suggested that clopidogrel may be less effective in reducing the rate of cardiovascular events among persons who are carriers of loss-of-function CYP2C19 alleles that are associated with reduced conversion of clopidogrel to its active met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819a78d62afb6bda735cd5a95aabbe47
https://doi.org/10.1056/nejmoa1008410

Effect of Safety and Environmental Variables on Task Durations in Steel Erection

Autor: Javier Irizarry, Katy L. Simonsen, Dulcy M. Abraham

Publikováno v: Journal of Construction Engineering and Management. 131:1310-1319

In spite of the efforts by government agencies, labor organizations, and researchers in the field of health and safety, injuries and fatalities continue to affect the construction industry. In 2002 the construction industry had the undesirable distin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::726b0da4776603cad7f92ea6e7de806b
https://doi.org/10.1061/(asce)0733-9364(2005)131:12(1310)

Implementing false discovery rate control: increasing your power

Autor: Lauren M. McIntyre, Katy L. Simonsen, Koen J. F. Verhoeven

Publikováno v: Oikos. 108:643-647

Popular procedures to control the chance of making type I errors when multiple statistical tests are performed come at a high cost: a reduction in power. As the number of tests increases, power for an individual test may become unacceptably low. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::671fc362ebc305c94532e8fc8a1620ff
https://doi.org/10.1111/j.0030-1299.2005.13727.x